Results 31 to 40 of about 12,752 (178)

Intrinsic and Chemotherapeutic Stressors Modulate ABCC-Like Transport in Trypanosoma cruzi

Molecules, 2021
Trypanosoma cruzi is the etiologic agent for Chagas disease, which affects 6–7 million people worldwide. The biological diversity of the parasite reflects on inefficiency of benznidazole, which is a first choice chemotherapy, on chronic patients.
Kelli Monteiro da Costa, Eduardo J. Salustiano, Raphael do Carmo Valente, Leonardo Freire-de-Lima, Lucia Mendonça-Previato, José Osvaldo Previato   +5 more
doaj   +1 more source

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
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Parasitemia and antibody response to benznidazole treatment in a cohort of patients with chronic Chagas disease

Frontiers in Parasitology, 2023
BackgroundEvaluating the effectiveness of Chagas disease treatment poses challenges due to the lack of biomarkers for disease progression and therapeutic response. In this study, we aimed to assess the clearance of Trypanosoma cruzi (T.
Carlos Henrique Valente Moreira, Carlos Henrique Valente Moreira, Ana Luiza Bierrenbach, Cesar Augusto Taconeli, Léa Campos de Oliveira-da Silva, Lewis F. Buss, Lewis F. Buss, Sheila M. Keating, Erika Regina Manuli, Erika Regina Manuli, Erika Regina Manuli, Noemia Barbosa Carvalho, Cristina Guastini, Sonia Bakkour Coco, Sonia Bakkour Coco, José Ângelo Lauletta Lindoso, José Ângelo Lauletta Lindoso, Lucas Augusto Moyses Franco, Lucas Augusto Moyses Franco, Fabio Ghilardi, Flavia Cristina da Silva Sales, Flavia Cristina da Silva Sales, Paul Contestable, Clara Di Germanio, Michael P. Busch, Michael P. Busch, Ester Cerdeira Sabino, Ester Cerdeira Sabino   +27 more
doaj   +1 more source

Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi [PDF]

, 2017
The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Burgos, Juan Miguel, Leguizamon, Maria Susana, Ojeda, Diego Sebastian, Pascuale, Carla Antonela, Quarleri, Jorge Fabian, Urquiza, Javier Mariano   +5 more
core   +1 more source

Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi = Atividade tripanocida da concentração genotóxica do benzonidazol em formas epimastigotas de Trypanosoma cruzi [PDF]

Acta Scientiarum. Health Sciences, 2012
The genotoxicity of benznidazole at a concentration of 75 µM, used in the treatment of Chagas’ disease, has been recently reported. The present study evaluated the inhibitory effect of benznidazole on the growth of epimastigote forms of T. cruzi I and II
Edilson Nobuyoshi Kaneshima, Marialba Avezum Alves Castro-Prado, Max Jean de Ornelas Toledo, Silvana Marques Araújo, Mônica Lúcia Gomes   +4 more
doaj   +1 more source

Caracterização físico-química do fármaco antichagásico benznidazol Physicochemical characterization of antichagasic benznidazole

Química Nova, 2010
Currently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties
Flávia Pires Maximiano, Guilherme Hideki Yoshizane Costa, Jacqueline de Souza, Marcílio Sérgio Soares da Cunha-Filho   +3 more
doaj   +1 more source

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source

Benznidazole [PDF]

Reactions Weekly, 2020
Samantha N. Steiger, Ramy H. Elshaboury, Ronak G. Gandhi   +2 more
  +5 more sources

Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina [PDF]

, 2013
Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi.
Altcheh, Jaime Marcelo, Ballering, Griselda, Berenstein, Ada, Biancardi, Miguel Angel, Espejo Cozzi, Andres, Freillij, Hector, Garcia Bournissen, Facundo, Hernandez, Susana, Moroni, Samanta, Moscatelli, Guillermo, Schwarcz, Marta, Siniawski, Susana, Tarlovsky, Ana   +12 more
core   +2 more sources

Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease.

PLoS ONE, 2015
The nitroheterocyclic drugs nifurtimox and benznidazole are first-line drugs available to treat Chagas disease; however, they have limitations, including long treatment courses and toxicity.
Tassiane Assíria Fontes Martins, Lívia de Figueiredo Diniz, Ana Lia Mazzeti, Álvaro Fernando da Silva do Nascimento, Sérgio Caldas, Ivo Santana Caldas, Isabel Mayer de Andrade, Isabela Ribeiro, Maria Terezinha Bahia   +8 more
doaj   +1 more source