Results 31 to 40 of about 12,797 (181)

Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century. [PDF]

, 2007
In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas ...
Albajar-Vinas, P, Bernal, O, Bulla, D, Morote, S, Villa, L   +4 more
core   +4 more sources

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source

Unveiling challenges in real-time PCR strategies for detecting treatment failure: observations from clinical trials on chronic Chagas disease

Frontiers in Parasitology, 2023
Chagas disease (CD) caused by Trypanosoma cruzi remains a Neglected Tropical Disease with limited access to diagnosis and treatment, particularly for chronically infected patients.
Alejandro G. Schijman
doaj   +1 more source

Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi [PDF]

, 2017
The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Burgos, Juan Miguel, Leguizamon, Maria Susana, Ojeda, Diego Sebastian, Pascuale, Carla Antonela, Quarleri, Jorge Fabian, Urquiza, Javier Mariano   +5 more
core   +1 more source

Optical Absorption of the Antitrypanocidal Drug Benznidazole inWater

Molecules, 2014
UV-vis optical absorption spectra of the antitrypanocidal drug benznidazole solvated in water were measured for various concentrations. The spectra show a prominent peak around 3.80 eV, while deconvolution of the UV-vis optical absorption spectra ...
Eveline M. Bezerra, João R. Bezerra-Neto, Francisco A. M. Sales, Ricardo P. dos Santos, Alice M. C. Martins, Pedro de Lima-Neto, Ewerton W. S. Caetano, Eudenilson L. Albuquerque, Valder N. Freire   +8 more
doaj   +1 more source

Poly-ε-Caprolactone Implants for Benznidazole Prolonged Release: An Alternative to Chagas Disease Oral Treatment

Pharmaceutics, 2023
Benznidazole (BZ) tablets are the currently prescribed treatment for Chagas disease. However, BZ presents limited efficacy and a prolonged treatment regimen with dose-dependent side effects. The design and development of new BZ subcutaneous (SC) implants
Ana Lia Mazzeti, Karolina R. Gonçalves, Patrícia Ferreira Boasquívis, Jamile Barbosa, Bruno G. Pereira, Maria de Nazaré Correia Soeiro, Vanessa Carla Furtado Mosqueira, Maria Terezinha Bahia   +7 more
doaj   +1 more source

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source

Benznidazole [PDF]

Reactions Weekly, 2020
Samantha N. Steiger, Ramy H. Elshaboury, Ronak G. Gandhi   +2 more
  +5 more sources

Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular Trypanosoma cruzi Amastigotes

mBio, 2018
The mammalian stages of the parasite Trypanosoma cruzi, the causative agent of Chagas disease, exhibit a wide host species range and extensive within-host tissue distribution.
Peter C. Dumoulin, Barbara A. Burleigh
doaj   +1 more source

Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease.

PLoS ONE, 2015
The nitroheterocyclic drugs nifurtimox and benznidazole are first-line drugs available to treat Chagas disease; however, they have limitations, including long treatment courses and toxicity.
Tassiane Assíria Fontes Martins, Lívia de Figueiredo Diniz, Ana Lia Mazzeti, Álvaro Fernando da Silva do Nascimento, Sérgio Caldas, Ivo Santana Caldas, Isabel Mayer de Andrade, Isabela Ribeiro, Maria Terezinha Bahia   +8 more
doaj   +1 more source