Results 61 to 70 of about 32,293 (248)

Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons

GeoHealth, 2021
In assessments of cancer risk from atmospheric polycyclic aromatic hydrocarbons (PAHs), scientists and regulators rarely consider the complex mixture of emitted compounds and degradation products, and they often represent the entire mixture using a ...
Jamie M. Kelly, Peter D. Ivatt, Mathew J. Evans, Jesse H. Kroll, Amy I. H. Hrdina, Ishwar N. Kohale, Forest M. White, Bevin P. Engelward, Noelle E. Selin   +8 more
doaj   +1 more source

Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants [PDF]

Carcinogenesis, 2001
Cytochrome P450 1A1 (CYP1A1) plays a key role in the metabolism of carcinogens, such as benzo[a]pyrene (B[a]P) and metabolites to ultimate carcinogens. Three human allelic variants, namely wild-type (CYP1A1.1), CYP1A1.2 (I462V) and CYP1A1.4 (T461N), were coexpressed by coinfection of baculovirus-infected insect cells with human NADPH-P450 reductase ...
D, Schwarz, P, Kisselev, I, Cascorbi, W H, Schunck, I, Roots   +4 more
openaire   +2 more sources

Rapid Mineralization of Benzo[ a ]pyrene by a Microbial Consortium Growing on Diesel Fuel

, 2000
A microbial consortium which rapidly mineralized the environmentally persistent pollutant benzo[ a ]pyrene was recovered from soil. The consortium cometabolically converted [7- 14 C]benzo[ a
Robert A. Kanaly, Kazuya Watanabe, Richard Bartha, Shigeaki Harayama   +3 more
core   +1 more source

Lymphocyte Micronucleus Formation Is Driven by Inflammation‐Induced Oxidative DNA Damage in Oesophageal Cancer Development

International Journal of Cancer, EarlyView.
Chromosomal instability is a hallmark of cancer, but minimally invasive ways to detect systemic DNA damage and cancer risk remain limited. Here, using patient blood samples, the authors investigated lymphocyte micronuclei (MN) frequency as a potential marker of DNA damage across the progression from gastroesophageal reflux disease to Barrett's ...
Kathryn Munn, Rachel Lawrence, Hasan Haboubi, Hamsa Naser, Kate Hurlow, Ume‐Kulsoom Shah, Lisa Williams, Sarah Gwynne, Owen Bodger, Jiri Zavadil, Francois Virard, Shareen Doak, Laura E. Thomas, Gareth Jenkins   +13 more
wiley   +1 more source

Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1 [PDF]

Carcinogenesis, 1998
Benzo[a]pyrene (B[a]P), a ubiquitous environmental, tobacco and dietary carcinogen, has been implicated in human cancer etiology. The role of human cytochrome P450 1B1 in the metabolism of B[a]P is poorly understood. Using microsomal preparations of human P450 1A1, 1A2 and 1B1 expressed in baculovirus-infected insect cells, as well as human and rat ...
J H, Kim, K H, Stansbury, N J, Walker, M A, Trush, P T, Strickland, T R, Sutter   +5 more
openaire   +2 more sources

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Does benzo[a]pyrene affect the heart embryonic development?

Annales Universitatis Paedagogicae Cracoviensis Studia Naturae, 2018
Benzo[a]pyrene is a polycyclic aromatic hydrocarbon of well proved toxic effect on animal cells and tissues. We used chicken in ovo developmental model to verify its influence on selected parameters of the heart rhythm and on the antioxidative defense in
Łukasz M. Kołodziejczyk, Magdalena Puzik, Agnieszka Greń, Marta Batoryna, Grzegorz Formicki, Edyta Kapusta   +5 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Toxic effects of complex mixed organic compounds in aerosols on Skeletonema costatum [PDF]

E3S Web of Conferences
Considering the complexity of organic components in aerosols, this study aimed to compare the toxic effects of mixed PAHs and the highly toxic benzo[a]pyrene on Skeletonema costatum (S. costatum).
Li Jiajia, Feng Lei
doaj   +1 more source

White light emitting molecular logic gates

Smart Molecules, EarlyView.
White light emitting smart molecules with Boolean logic computing ability are surveyed. Abstract White light emitting (WLE) materials are of considerable interest with commercial and societal applications in video displays and lighting devices. A characteristic property of WLE materials is the luminescence profile spanning from 380 to 700 nm.
Davide Benedetto Tiz, Massimo Catania, David C. Magri   +2 more
wiley   +1 more source