Abstract Objective A Pediatric Investigation Plan (PIP) implemented under the European Pediatric Regulation (EC No. 1901/2006) aims to ensure early and systematic evaluation of medicines for children. We analyze PIPs for antiseizure medications (ASMs) submitted to the European Medicines Agency (EMA) since 2006, characterizing their content, focusing on
Valeria Agostini, Stéphane Auvin
wiley +1 more source
Correction: Domingues et al. Pediatric Drug Development: Reviewing Challenges and Opportunities by Tracking Innovative Therapies. <i>Pharmaceutics</i> 2023, <i>15</i>, 2431. [PDF]
Domingues C +4 more
europepmc +1 more source
The use of nanotechnology in sunscreens has increased, with various filters and organoclays tested for new intercalated formulations. As animal toxicity tests decrease, New Approach Methodologies are favoured. The S4 + OMC‐NC improved cell survival under SSL and showed antimutagenic properties, making it a promising candidate for safe photoprotection ...
Daniel Mabundu Kibwila +6 more
wiley +1 more source
S. Asath Bahadur +3 more
openaire +1 more source
Reinventing henna: Enzyme‐catalysed colour release from stabilized Lawsonia inermis L. extracts
The instability and reduced dyeing performance of a cosmetic formulation containing 2‐hydroxy‐1,4‐naphthoquinone (lawsone), derived from Lawsonia inermis L., is demonstrated in comparison to a novel two‐component system. This system comprises one formulation with naturally occurring lawsone precursors and a second containing a specific hydrolase ...
Nele Dallmann +2 more
wiley +1 more source
The intramolecular stabilizing effects of <i>O</i>-benzoyl substituents as a driving force of the acid-promoted pyranoside-<i>into</i>-furanoside rearrangement. [PDF]
Gerbst AG +5 more
europepmc +1 more source
Synthesis and Evaluation of Methyl 4-(7-Hydroxy-4,4,8-Trimethyl-3-Oxabicyclo[3.3.1]Nonan-2-yl)Benzoate as an Antileishmanial Agent and Its Synergistic Effect with Miltefosine [PDF]
Prachi Bhalla +4 more
openalex +1 more source
ABSTRACT Intensification of fish aquaculture worldwide has led to severe problems of diseases caused by parasitic dactylogyrideans. In this study, the anti‐dactylogyridean efficacy of treating Colossoma macropomum with baths of emamectin benzoate (EMB) was investigated for the first time, along with the effects of this treatment on the haematology and ...
Raimundo Rosemiro de Jesus Baia +4 more
wiley +1 more source
Screening of microbial consortium with high efficiency of lignin-degrading and its synergistic metabolic mechanism. [PDF]
Ru J +6 more
europepmc +1 more source
Wettability of saliva substitutes across various denture base fabrication techniques
Abstract Purpose The present study evaluated the contact angles (CAs) of four denture base materials subjected to different surface treatments using deionized water and saliva substitutes. Material and Methods A total of 32 rectangular specimens were manufactured using four different denture base materials: heat‐cured compression molded Lucitone 199 (C)
Paul Mikhail +3 more
wiley +1 more source

