Results 221 to 230 of about 98,405 (294)

Benzodiazepines: a summary of pharmacokinetic properties.

open access: bronze, 1981
D J Greenblatt   +3 more
openalex   +1 more source

Tumor‐related epilepsy in glioma: A multidisciplinary overview

open access: yesEpilepsia, EarlyView.
Abstract Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an
Roberto Michelucci   +29 more
wiley   +1 more source

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

open access: yesEpilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire   +9 more
wiley   +1 more source

Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications

open access: yesEpilepsia, EarlyView.
Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls   +13 more
wiley   +1 more source

Familial adult myoclonus epilepsy: A comprehensive diagnostic strategy for clinical practice

open access: yesEpilepsia, EarlyView.
Abstract Familial adult myoclonus epilepsy (FAME) is a genetic neurological disorder characterized by cortical myoclonus and epileptic seizures with clinical features that overlap with other movement disorders and epileptic syndromes, particularly essential tremor (ET), progressive myoclonic epilepsy (PME), and juvenile myoclonic epilepsy (JME).
Yitao Lu   +14 more
wiley   +1 more source

Folate transfer across the placenta during late pregnancy in women with epilepsy: A cross‐sectional, two‐center study

open access: yesEpilepsia, EarlyView.
Abstract Objective In women with epilepsy who are treated with antiseizure medications (ASMs), folate concentrations in maternal serum may not be a good indicator of fetal folate supply, because ASMs can interfere with folate handling by the placenta. We aimed to assess the transplacental folate transfer at birth in persons with epilepsy in comparison ...
Erez Berman   +6 more
wiley   +1 more source

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