Results 231 to 240 of about 156,110 (291)

Harm reduction approaches for the use of benzodiazepines: a scoping review. [PDF]

Harm Reduct J
Morrison C, Natale I, Branchflower A, Harvey C, Lundin RM.   +4 more
europepmc   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Flumazenil Reversal of Remimazolam Sedation During Posterior Spinal Fusion in Two Adolescents. [PDF]

J Med Cases
Lee N, Moon K, Uffman JC, Tobias JD.
europepmc   +1 more source

An extreme type of new onset refractory status epilepticus with stimulus‐induced seizures in pharmacological isoelectric states

Epilepsia, EarlyView.
Abstract Objective Status epilepticus (SE) is a common neurological emergency associated with high morbidity and mortality. SE is classified as refractory when it persists despite benzodiazepine and second‐line antiseizure medication. Managing refractory SE in the intensive care setting often requires high doses of sedative drugs, which can induce ...
Julie Lévi‐Strauss, Vi‐Huong Nguyen‐Michel, Espártaco Moraes Ribeiro, Virginie Lambrecq, Aurélie Hanin, Sophie Demeret, Vincent Navarro   +6 more
wiley   +1 more source

Facilitators and barriers to the deprescribing of benzodiazepines and Z-drug hypnotics in patients under 65 on adult mental health wards. [PDF]

Sci Rep
Filmer S, Maidment I.
europepmc   +1 more source

Pharmacokinetics and tolerability of single‐dose Staccato® alprazolam in adolescents with epilepsy, and population pharmacokinetic analysis to support dose selection in adolescents

Epilepsia, EarlyView.
This is a graphical representation of the abstract and article highlights. Abstract Objective Staccato® alprazolam is a hand‐held inhalation device that provides rapid systemic delivery of alprazolam through the intrapulmonary route. This trial explored the pharmacokinetics and tolerability of single‐dose Staccato alprazolam 2 mg in adolescents with ...
Pavel Klein, Gewalin Aungaroon, Victor Biton, Kore Kai Liow, Steven Phillips, Thomas Wychowski, Ahmed Sadek, Jan‐Peer Elshoff, Robert Roebling, Aliceson King, Chiara C. Rospo, Rik Schoemaker, Hugues Chanteux   +12 more
wiley   +1 more source

Assessment of benzodiazepine dosing in status epilepticus patients in the emergency department. [PDF]

Front Neurol
Aljadeed RI, Alkaf A, Alhajlbrahim D, Alewairdhi H, Assiri GA, Aljadeed R, Almalag H, Kalagi N.   +7 more
europepmc   +1 more source

Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum

, 2005
Jae Kyu Ryu, Hyun B. Choi, James G. McLarnon   +2 more
openalex   +2 more sources

Artificial intelligence‐driven closed‐loop devices in sudden unexpected death in epilepsy prediction and prevention: Insights from persons with epilepsy and caregivers

Epilepsia, EarlyView.
Abstract Objective The absence of strategies for predicting and preventing sudden unexpected death in epilepsy (SUDEP) is intertwined with the lack of studies measuring users' attitudes toward potential innovative interventions. The NEUROSENSE Project (http://www.neurosense‐project.eu) aims to evaluate novel SUDEP‐predictive neuroendocrine biomarkers ...
João Ferreira, Miguel França, Mariana Cardoso Regalo, Mariana Rei, Ricardo Peixoto, José Ángel Aibar, Torie Robinson, Ricardo Matias, Fabrice Duprat, Massimo Mantegazza, Onur Parlak, Philippe Ryvlin, Sándor Beniczky, Lígia Lopes, Emilio Perucca, João Claro, Carlos Conde   +16 more
wiley   +1 more source