Results 251 to 260 of about 138,894 (338)
Real‐World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors
Acta Paediatrica, EarlyView.ABSTRACT Aim This study assessed neurodevelopmental outcomes in neonates with hypoxic‐ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) outside randomised controlled trials (RCTs). It also aimed to identify predictors of outcomes and evaluate TH practices across centres.
Luca Bedetti +23 more
wiley +1 more source
Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist‐Control Study
Acta Paediatrica, EarlyView.ABSTRACT Aim Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. This mechanism may contribute to improvements in autism‐related symptoms. The present study builds on the preclinical research and on previous clinical research on bumetanide treatment for children
Elisabeth Fernell +7 more
wiley +1 more source
New Synthesis of 1,4-Benzodiazepine Derivatives via Palladium Catalyzed Carbonylation
, 1984 Miwako Mori +4 more
openalex +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Over 20% of individuals with IBD were prescribed pain or sedative medications annually, with rising chronic and co‐prescribing rates. Risk factors included female sex, older age, Crohn's disease, and mental health conditions. Targeted interventions are needed to reduce harmful prescribing and promote safer alternatives.
Samantha Baillie +6 more
wiley +1 more source
Benzodiazepines: a summary of pharmacokinetic properties.
, 1981 D J Greenblatt +3 more
openalex +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito +6 more
wiley +1 more source