Results 181 to 190 of about 207,949 (383)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar   +4 more
wiley   +1 more source

The choroid plexus water density

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose To quantify normative ranges and circadian variability of the choroid plexus (ChP) water density in healthy adults. Methods Actigraphy assessments of circadian activity were performed for 5 days in healthy participants (n = 15; age = 28.5 ± 6.5 years) and subsequently participants underwent repeated, high spatial resolution proton ...
Abigail R. Dubois   +8 more
wiley   +1 more source

Unveiling the Therapeutic Potential of Atractylis aristata Batt. Aqueous Extract: Anti‐inflammatory, Antioxidant, Antibacterial, Sedative Activities & Phytochemical Profiling

open access: yesChemistryOpen, EarlyView.
This study evaluates the pharmacological properties of the aqueous extract of Atractylis aristata, focusing on its antioxidant, anti‐inflammatory, antibacterial, and sedative activities. Phytochemical analysis identifies bioactive compounds, while in vitro and in vivo tests demonstrate its therapeutic potential in addressing oxidative stress ...
Asma Abid   +14 more
wiley   +1 more source

Investigating the Pattern of Benzodiazepine Poisoning in Gorgan, 2008-2014

open access: yesJournal of Clinical and Basic Research, 2018
Background and objectives: Benzodiazepine poisoning is one of the most important and common medical emergencies worldwide. The purpose of this study was to evaluate the pattern of poisoning with benzodiazepines in Gorgan, Iran.
Yaghoub Shayeste   +4 more
doaj  

Interaction between phenytoin and the benzodiazepines. [PDF]

open access: bronze, 1971
Frank Vajda   +2 more
openalex   +1 more source

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights

open access: yesChemistryOpen, EarlyView.
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas   +8 more
wiley   +1 more source

Weathering the storms of climate change: Preparing persons with disabilities and the physiatrists who provide their care for extreme hurricanes

open access: yesPM&R, EarlyView.
Abstract Climate‐driven disasters have disproportionate and often devastating consequences on individuals with disabilities. Warming ocean and air temperatures are fueling more extreme tropical cyclones, further endangering those living in at‐risk regions.
Mollie Andreae   +4 more
wiley   +1 more source

Low‐value interventions to deimplement: A secondary analysis of a systematic review of low back pain clinical practice guidelines

open access: yesPM&R, EarlyView.
Abstract Objective To perform a secondary review of low back pain (LBP) clinical practice guidelines (CPG) identified in a recently conducted systematic review and to synthesize and summarize low‐value recommendations as practices that may be candidates for deimplementation.
Daniel Tai   +5 more
wiley   +1 more source

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