Results 121 to 130 of about 64,070 (311)

Heat drastically alters floral color and pigment composition without affecting flower conspicuousness

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Floral pigments primarily serve to attract pollinators through color display and also contribute to protection against environmental stress. Although pigment composition can be plastically altered under stress, its impact on pollinator color perception remains poorly understood.
Eduardo Narbona   +6 more
wiley   +1 more source

Late‐Stage Conversion of Terminal Alkynes to Nitriles in Nucleoside Scaffolds: A Tool for Diversification

open access: yesAsian Journal of Organic Chemistry, EarlyView.
We established a metal‐free, late‐stage diversification of terminal alkynes into nitriles using tert‐butyl nitrite (tBuONO). Replacing 2‐picoline N‐oxide with N‐methylmorpholine N‐oxide (NMO) as the oxidant enabled efficient nitrile formation under mild conditions. Abstract The small nucleoside molecule LJ‐4827 exhibited potent kinase inhibition and in
Yun A Yum   +5 more
wiley   +1 more source

Harnessing Colloidal Dispersion for Laccase‐Driven Enzymatic Depolymerization of Polystyrene

open access: yesAngewandte Chemie, EarlyView.
Polystyrene (PS), long considered non‐degradable by biocatalytic pathways, can now be broken down under aqueous conditions using atmospheric air and a laccase–mediator system composed of a commercially available fungal enzyme and 1‐hydroxybenzotriazole as small organic mediator.
Manon Pujol   +5 more
wiley   +1 more source

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

open access: yesAngewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann   +10 more
wiley   +1 more source

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen   +4 more
wiley   +1 more source

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