Rotenone: from modelling to implication in Parkinson’s disease
Folia Neuropathologica, 2019 Rotenone ([2R-(2α,6aα,12aα)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyran[3,4-b]furo [2,3-h][1]benzopyran-6(6aH)-one) is a naturally occurring compound derived from the roots and stems of Derris, Tephrosia, Lonchocarpus and ...
Khaled Radad +6 more
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Cis-glyco-fused benzopyran derivatives as hit compounds for the development of therapeutic and diagnostic tools against neurodegenerative diseases [PDF]
, 2014 Oligomeric and fibrillar aggregates generated by amyloid-β (Aβ) and prion protein (PrP) peptides are amongst the principal components of amyloid plaques found post mortem in patients suffering from Alzheimer's disease and mammalian prion diseases.
Sironi E. +7 more
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8-Hydroxy-5,6,7-trimethoxy-2-phenyl-4H-chromen-4-one
Acta Crystallographica Section E, 2008 In the title compound, C18H16O6, the benzopyran group is essentially planar, with the O atoms of the substituent groups lying close to its mean plane. The molecular conformation is governed by intramolecular interactions.
J. Ellena +4 more
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3-Hemiacetals of 3,4-Dihydrospiro[2H-1-benzopyran-2,1'(3'H)-isobenzofuran]-3,4-dione [PDF]
, 1975 Oxidation of 2?-hydroxymethylfiavonol with periodic acid in methanol gives 3,4-dihydro-3-hydroxy-3-methoxyspiro[2H-1-benzopyran-2,1'(3'H)- isobenzofuran]-4-one.
EJ McGarry, JW Clark-Lewis
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Synthesis of Deuterated Benzopyran Derivatives as Selective COX‑2 Inhibitors with Improved Pharmacokinetic Properties [PDF]
, 2016 We designed a series of specifically deuterated benzopyran analogues as new COX-2 inhibitors with the aim of improving their pharmacokinetic properties. As expected, the deuterated compounds retained potency and selectivity for COX-2.
Jianqi Liu (1738939) +10 more
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Synthesis and Antimicrobial Activities of Some Sulphur Containing Chromene Derivatives
Natural Product Communications, 2012 A series of 3,3-dimethyl-3 H benzothieno[3,2- f ][1]-benzopyran analogues modified at the pyran 1,2-double bond were synthesized. The corresponding dihydro and (±)-cis-diol derivatives were converted into diacetate and cyclic carbonate upon acylation ...
Tuba Şerbetçi +4 more
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Solid-Phase Parallel Synthesis of Drug-Like Artificial 2<em>H</em>-Benzopyran Libraries
Molecules, 2012 This review covers the construction of drug-like 2<em>H</em>-benzopyrans and related libraries using solid-phase parallel synthesis. In this context, the preparation of substituted benzopyrans such as mono-, di- and trisubstituted benzopyran ...
Young-Dae Gong, Taeho Lee
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In-Silico Study, Synthesis and Pharmacological Screening of Novel Benzopyran-3-Carbonyl Derivatives as Antidiabetic Agents [PDF]
Introduction: In the current work, in-silico docking investigation for 60 benzopyran-3-carbonyl derivatives was conducted since benzopyran derivatives play a vital role in many different research disciplines.
Bhartendu Sharma, Ranjit Singh
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Synthesis of Some New Heteroarylamino-3-Nitro-2H-[1]-Benzopyran-2-ones and their Antibacterial Activity [PDF]
, 2016 Novel derivatives of benzopyran-2-ones are synthesized by catalytic condensation reaction. 4-(3-Hydroxy-2-pyridinylamino)- 3-nitro-2H-[1]-benzopyran-2-one 4a, 4-(4-methyl-3-nitro-2-pyridinylamino)-3-nitro-2H-[1]-benzopyran-2-one, 4b and 4 ...
Ismaili, Hamit +4 more
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Modulation of Vascular Reactivity by Novel Synthetic Benzopyran Analogues in Rat Aortas [PDF]
, 2016 A substantial body of research described ATP-dependent potassium (K ATP ) channels, sarcolemmal and mitochondrial, with different physiological functions and pharmacological behaviour in various tissues (pancreatic â-cells, brain, skeletal muscle and
Bedreag, O. +7 more
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