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The Role of Natural and Synthetic Flavonoids in the Prevention of Marine Biofouling [PDF]
Marine DrugsMarine biofouling is a major concern for the maritime industry, environment, and human health. Biocides which are currently used in marine coatings to prevent this phenomenon are toxic to the marine environment, and therefore a search for antifoulants ...
Daniela Pereira +4 more
doaj +7 more sources
Synthetic Flavonoids as Novel Modulators of Platelet Function and Thrombosis [PDF]
International Journal of Molecular Sciences, 2019 Cardiovascular diseases represent a major cause of mortality and morbidity in the world, and specifically, thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within the blood vessels during pathological circumstances.
Thomas M Vallance +2 more
exaly +8 more sources
An Improved Synthetic Method for Sensitive Iodine Containing Tricyclic Flavonoids
Molecules, 2022 The synthesis of new iodine containing synthetic tricyclic flavonoids is reported. Due to the sensitivity of the precursors to the heat and acidic conditions required for the ring closure of the 1,3-dithiolium core, a new cyclization method has been ...
Mihail Lucian Birsa, Laura G. Sarbu
doaj +6 more sources
Inhibition of UGT1A1 by natural and synthetic flavonoids [PDF]
International Journal of Biological Macromolecules, 2019 Flavonoids are widely distributed phytochemicals in vegetables, fruits and medicinal plants. Recent studies demonstrate that some natural flavonoids are potent inhibitors of the human UDP-glucuronosyltransferase 1A1 (UGT1A1), a key enzyme in detoxification of endogenous harmful compounds such as bilirubin.
Xia Lv, Chun-Zhi Ai, Qi-Hang Zhou
exaly +6 more sources
Molecules, 2022 Herein, we report the use of the Suzuki–Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays.
Martina Hurtová +5 more
doaj +4 more sources
Antibacterial and Antifungal Properties of New Synthetic Tricyclic Flavonoids
AntibioticsBackground/Objectives: The discovery of new molecules to which bacteria have not yet developed resistance is a significant medical priority. Synthetic flavonoids are good candidates for developing new antimicrobials.
Laura Gabriela Sarbu +2 more
doaj +4 more sources
Systematic Exploration of Natural and Synthetic Flavonoids for the Inhibition of Staphylococcus aureus Biofilms [PDF]
International Journal of Molecular Sciences, 2013 When single-cell (or suspended) bacteria switch into the biofilm lifestyle, they become less susceptible to antimicrobials, imposing the need for anti-biofilms research. Flavonoids are among the most extensively studied natural compounds with an unprecedented amount of bioactivity claims.
Pia M Vuorela +2 more
exaly +6 more sources
Synthetic Biology towards Improved Flavonoid Pharmacokinetics [PDF]
Biomolecules, 2021 Flavonoids are a structurally diverse class of natural products that have been found to have a range of beneficial activities in humans. However, the clinical utilisation of these molecules has been limited due to their low solubility, chemical stability,
Moon Sajid +3 more
doaj +3 more sources
In Vivo Antistress Effects of Synthetic Flavonoids in Mice: Behavioral and Biochemical Approach. [PDF]
Molecules, 2022 Natural flavonoids, in addition to some of their synthetic derivatives, are recognized for their remarkable medicinal properties. The present study was designed to investigate the in vitro antioxidant and in vivo antistress effect of synthetic flavonoids (flavones and flavonols) in mice, where stress was induced by injecting acetic acid and physically ...
Ghias M +6 more
europepmc +4 more sources
Molecules, 2010 Flavonoids and their photochemical transformations play an important role in biological processes in nature. Synthetic photochemistry allows access to molecules that cannot be obtained via more conventional methods.
Jan H. Van der Westhuizen +3 more
doaj +2 more sources