Results 11 to 20 of about 91,886 (301)

Synthetic Flavonoids as Novel Modulators of Platelet Function and Thrombosis [PDF]

International Journal of Molecular Sciences, 2019
Cardiovascular diseases represent a major cause of mortality and morbidity in the world, and specifically, thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within the blood vessels during pathological circumstances.
Thomas M. Vallance, Divyashree Ravishankar, Dina A. I. Albadawi, Helen M. I. Osborn, Sakthivel Vaiyapuri   +4 more
europepmc   +6 more sources

Synthetic Biology towards Improved Flavonoid Pharmacokinetics [PDF]

Biomolecules, 2021
Flavonoids are a structurally diverse class of natural products that have been found to have a range of beneficial activities in humans. However, the clinical utilisation of these molecules has been limited due to their low solubility, chemical stability,
Moon Sajid, Chaitanya N. Channakesavula, Shane R. Stone, Parwinder Kaur   +3 more
doaj   +3 more sources

The Role of Natural and Synthetic Flavonoids in the Prevention of Marine Biofouling [PDF]

Marine Drugs
Marine biofouling is a major concern for the maritime industry, environment, and human health. Biocides which are currently used in marine coatings to prevent this phenomenon are toxic to the marine environment, and therefore a search for antifoulants ...
Daniela Pereira, Madalena Pinto, Joana R. Almeida, Marta Correia-da-Silva, Honorina Cidade   +4 more
doaj   +2 more sources

Synthetic flavonoids with antimicrobial activity: a review [PDF]

Journal of Applied Microbiology, 2019
The emergence of drug-resistant microbes left us with a great need for new antimicrobial agents. Flavonoids, with their wide range of biological activities, are good candidates in this respect. Although naturally occurring flavonoids are the most studied ones, semi-synthetic or synthetic flavonoids have proven to have great potential, inhibiting and ...
L.G. Sarbu, L.G. Bahrin, C. Babii, M. Stefan, M.L. Birsa   +4 more
openaire   +4 more sources

Synthetic flavonoids as potential antiviral agents against SARS-CoV-2 main protease [PDF]

Journal of Biomolecular Structure and Dynamics, 2020
The COVID-19 pandemic has claimed more than a million lives worldwide within a short time span. Due to the unavailability of specific antiviral drugs or vaccine, the infections are causing panic both in general public and among healthcare providers. Therefore, an urgent discovery and development of effective antiviral drug for the treatment of COVID-19
Batool, Farwa, Mughal, Ehsan Ullah, Zia, Komal, Sadiq, Amina, Naeem, Nafeesa, Javid, Asif, Ul-Haq, Zaheer, Saeed, Muhammad   +7 more
openaire   +3 more sources

The Antimicrobial and Cytotoxicity Properties of New Dibrominated 1,3-Dithiolium Flavonoids [PDF]

Pharmaceuticals
Background/Objectives: Antimicrobial resistance (AMR) presents a medical risk as well as a significant global socioeconomic challenge. Key contributors to AMR include the excessive use and incorrect application of antibiotics in humans and agriculture ...
Laura Gabriela Sarbu, Ana Alexandra Dumitru, Mihaela Savu, Isabela Andreea Sandu, Lucian Gabriel Bahrin, Marius Stefan, Mihail Lucian Birsa   +6 more
doaj   +2 more sources

Inhibition of UGT1A1 by natural and synthetic flavonoids [PDF]

International Journal of Biological Macromolecules, 2019
Flavonoids are widely distributed phytochemicals in vegetables, fruits and medicinal plants. Recent studies demonstrate that some natural flavonoids are potent inhibitors of the human UDP-glucuronosyltransferase 1A1 (UGT1A1), a key enzyme in detoxification of endogenous harmful compounds such as bilirubin.
Liu, Xin-Yu, Lv, Xia, Wang, Ping, Ai, Chun-Zhi, Zhou, Qi-Hang, Finel, Moshe, Fan, Bin, Cao, Yun-Feng, Tang, Hui, Ge, Guang-Bo   +9 more
openaire   +5 more sources

An Improved Synthetic Method for Sensitive Iodine Containing Tricyclic Flavonoids

Molecules, 2022
The synthesis of new iodine containing synthetic tricyclic flavonoids is reported. Due to the sensitivity of the precursors to the heat and acidic conditions required for the ring closure of the 1,3-dithiolium core, a new cyclization method has been ...
Mihail Lucian Birsa, Laura G. Sarbu
doaj   +3 more sources

Antibacterial and Antifungal Properties of New Synthetic Tricyclic Flavonoids

Antibiotics
Background/Objectives: The discovery of new molecules to which bacteria have not yet developed resistance is a significant medical priority. Synthetic flavonoids are good candidates for developing new antimicrobials.
Laura Gabriela Sarbu, Irina Rosca, Mihail Lucian Birsa   +2 more
doaj   +3 more sources

Photochemistry of Flavonoids

Molecules, 2010
Flavonoids and their photochemical transformations play an important role in biological processes in nature. Synthetic photochemistry allows access to molecules that cannot be obtained via more conventional methods.
Jan H. Van der Westhuizen, Susan L. Bonnet, Daneel Ferreira, Miroslav Sisa   +3 more
doaj   +3 more sources