Results 11 to 20 of about 52,872 (276)

Synthetic flavonoids with antimicrobial activity: a review [PDF]

Journal of Applied Microbiology, 2019
The emergence of drug-resistant microbes left us with a great need for new antimicrobial agents. Flavonoids, with their wide range of biological activities, are good candidates in this respect. Although naturally occurring flavonoids are the most studied ones, semi-synthetic or synthetic flavonoids have proven to have great potential, inhibiting and ...
Mihail Lucian Birsa
exaly   +3 more sources

Chiral Flavonoids as Antitumor Agents

Pharmaceuticals, 2021
Flavonoids are a group of natural products with a great structural diversity, widely distributed in plant kingdom. They play an important role in plant growth, development and defense against aggressors.
Cláudia Pinto, Honorina Cidade, Madalena Pinto, Maria Elizabeth Tiritan   +3 more
doaj   +2 more sources

Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm

Journal of Pure and Applied Microbiology, 2023
Recent instances of novel biological circuits that enable cells to gain biosynthetic skills demonstrate synthetic biology’s therapeutic potential. Synthetic biology is a branch of biology whose primary role is to build completely functional biological ...
P.A. Aboobacker, Latha Ragunathan, Thiyagarajan Sanjeevi, Aarthi Manoharan, Aravind C. Sasi, Vishnu Chandran, Kavitha Kannaiyan, Marcella Sherin Samuel   +7 more
doaj   +3 more sources

The Antimicrobial and Cytotoxicity Properties of New Dibrominated 1,3-Dithiolium Flavonoids [PDF]

Pharmaceuticals
Background/Objectives: Antimicrobial resistance (AMR) presents a medical risk as well as a significant global socioeconomic challenge. Key contributors to AMR include the excessive use and incorrect application of antibiotics in humans and agriculture ...
Laura Gabriela Sarbu, Ana Alexandra Dumitru, Mihaela Savu, Isabela Andreea Sandu, Lucian Gabriel Bahrin, Marius Stefan, Mihail Lucian Birsa   +6 more
doaj   +2 more sources

Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review

Molecules, 2021
Flavonoids belong to a class of plant secondary metabolites that have a polyphenol structure. Flavonoids show extensive biological activity, such as antioxidative, anti-inflammatory, anti-mutagenic, anti-cancer, and antibacterial properties, so they are ...
Hanghang Lou, Lifei Hu, Hongyun Lu, Tianyu Wei, Qihe Chen   +4 more
doaj   +2 more sources

Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties. [PDF]

Bioorg Med Chem Lett, 2017
Flavonoids, stilbenes, and chalcones are plant secondary metabolites that often possess diverse biological activities including anti-inflammatory, anti-cancer, and anti-viral activities. The wide range of bioactivities poses a challenge to identify their targets. Here, we studied a set of synthetically generated flavonoids and chalcones to evaluate for
Mateeva N, Eyunni SVK, Redda KK, Ononuju U, Hansberry TD, Aikens C, Nag A.   +6 more
europepmc   +4 more sources

Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids

Molecules, 2016
Diverse flavonoids are abundant in dietary food constituents and possess useful biological activities. However, some flavonoids have limited bioavailability due to their low solubility in water.
Seyeon Park
doaj   +2 more sources

Flavonoids as GABAA receptor ligands: the whole story? [PDF]

Journal of Experimental Pharmacology, 2012
Cristina Wasowski, Mariel MarderInstituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, ArgentinaAbstract: Benzodiazepines are the most ...
Wasowski C, Marder M
doaj   +2 more sources

In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice

Neuropharmacology, 2013
The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work the capacity of a series of flavonoids to bind to the μ opioid receptor was evaluated.
Cristina Wasowski, Mariel Marder
exaly   +4 more sources

Fig. 3 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

, 2021
Fig. 3. Chemical structures of prenylated flavonoids with cytotoxicity (1–196).Published as part of Shi, Shaochun, Li, Jichong, Zhao, Xuemei, Liu, Qingbo & Song, Shao-Jiang, 2021, A comprehensive review: Biological activity, modification and synthetic ...
Liu, Qingbo, Shi, Shaochun, Li, Jichong, Zhao, Xuemei, Song, Shao-Jiang   +4 more
core   +5 more sources