Results 111 to 120 of about 2,430 (167)

Benzothiadiazines derivatives as novel allosteric modulators of kainic acid receptors.

Journal of Physiology and Pharmacology, 2022
The majority of excitatory neurotransmission in vertebrate CNS is mediated by glutamate binding to different types of receptors. Among them, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and kainite receptors (KAR) are ionotropic ...
G. Puja, F. Ravazzini, G. Losi, R. Bardoni, U. Battisti, C. Citti, G. Cannazza   +6 more
semanticscholar   +1 more source

Syntheses of 1,2,4-benzothiadiazine 1-oxides and 1,2,4-benzothiadiazines

The Journal of Organic Chemistry, 1980
Neville Finch, Ronald K. Rodebaugh, Salvatore Ricca, L. H. Werner   +3 more
openaire   +3 more sources

EFFECTS OF BENZOTHIADIAZINES ON SERUM AND TOTAL BODY ELECTROLYTES*

Annals of the New York Academy of Sciences, 1960
Antonio J. Carballo, Peter J. Talso
openaire   +4 more sources

ChemInform Abstract: Structural Studies on Benzothiadiazine Derivatives: 3‐Amino‐4H‐1,2,4‐benzothiadiazine 1,1‐Dioxide and 3‐Hydrazino‐4H‐1,2,4‐benzothiadiazine 1,1‐Dioxide [PDF]

ChemInform, 1989
C 7 H 7 N 3 O 2 S (1) cristallise dans Cc avec a=14,259, b=22,539 et c=8,741 A, β=114,10 o , Z=12; affinement jusqu'a R=0,040. C 7 H 8 N 4 O 2 S (2) cristallise dans P2 1 /n avec a=6,976, b=8,403 et c=14,748 A, β=90,25 o , Z=4; affinement jusqu'a R=0,042.
S. Todeschi, M. Di Bella, Gabriella Bombieri, Daniela Braghiroli, Francesco Demartin   +4 more
openaire   +2 more sources

A Potent New Benzothiadiazine Diuretic

Nature, 1960
SINCE the discovery of chlorothiazide by Beyer et al. 1, a number of chemically related compounds have been shown to possess similar natriuretic and chloruretic actions2–4. Some of these agents, notably 3,4-dihydrochlorothiazide and its derivatives, differ from chlorothiazide primarily in a greater milligram potency, which may be associated with a ...
Richard M. Taylor, Martin M. Winbury
openaire   +3 more sources

Some 1H-4,1,2-benzothiadiazines and 1H-4,1,2-benzothiadiazine 4,4-dioxides

Journal of the Chemical Society, Perkin Transactions 1, 1978
Interamolecular displacement of the o-nitro-group of 1-(2-nitrophenylthio)pyruvaldehyde 1-phenylhydrazone, under basic conditions, gives 3-acetyl-1-phenyl-1H-4,1,2-benzothiadiazine which was oxidised to the 4,4-dioxide. Ethyl 2-nitrophenylsulphonylglyoxylate phenylhydrazone gives only 2-nitrodiphenylamine under these conditions, but reduction to the 2 ...
Donald E. Ames, Sosale Chandrasekhar, Kristian J. Hansen   +2 more
openaire   +6 more sources

The Diabetogenic Activity of Benzothiadiazines

JAMA, 1964
To the Editor:— Because benzothiadiazines have been used so widely for many diverse conditions—including even obesity—any comment on the diabetogenic effect of this class of compounds is important. It is not surprising that a respected senior investigator such as Dr.
William W. Parmley, Frederick W. Wolff
openaire   +2 more sources

Hypotensive Activity of Two Benzothiadiazine Derivatives

Journal of Pharmaceutical Sciences, 1965
4-Hydrazino-1,2,3-benzothiadiazine-1,1 dioxide hydrochloride (EX 4211A) and 6-chloro-3,4-dihydro-3-( β -oxo- n -propyl)-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide phthalazone azine (EX 5004) were studied in the rat and dog to elucidate the mechanism(s) by which these compounds produced hypotensive effects.
Albert I. Edlin, Joseph P. Buckley, William J. Kinnard, Eugene E. Vogin   +3 more
openaire   +3 more sources

QSAR and Docking Studies on 1,1-Dioxo-2H-benzothiadiazines Acting as HCV NS5B Polymerase Inhibitors

, 2015
Quantitative structure-activity relationship (QSAR) and molecular modeling studies have been made on a large series of 1,1-dioxo-2H-benzothiadiazines acting as HCV NS5B polymerase inhibitors. A multiple linear regression analysis has pointed out that the
Satya Guptac, V. Agrawal, Izhar Ahmad, B. Shaik, Neelu Singh, K. Anithaa   +5 more
semanticscholar   +1 more source

Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.

Journal of Medicinal Chemistry, 2009
The hepatitis C virus (HCV) NS5B polymerase is essential for viral replication and has been a prime target for drug discovery research. Our efforts directed toward the discovery of HCV polymerase inhibitors resulted in the identification of unsymmetrical
R. Wagner, D. Larson, D. Beno, Todd D. Bosse, J. Darbyshire, Yi Gao, B. D. Gates, Wenping He, R. Henry, L. Hernandez, D. Hutchinson, Wen W Jiang, W. Kati, L. L. Klein, G. Koev, W. Kohlbrenner, A. C. Krueger, Jinrong Liu, Yaya Liu, M. Long, C. Maring, Sherie V Masse, T. Middleton, D. Montgomery, J. Pratt, P. Stuart, A. Molla, D. Kempf   +27 more
semanticscholar   +1 more source