Results 121 to 130 of about 547 (150)

Some 1H-4,1,2-benzothiadiazines and 1H-4,1,2-benzothiadiazine 4,4-dioxides

Journal of the Chemical Society, Perkin Transactions 1, 1978
Interamolecular displacement of the o-nitro-group of 1-(2-nitrophenylthio)pyruvaldehyde 1-phenylhydrazone, under basic conditions, gives 3-acetyl-1-phenyl-1H-4,1,2-benzothiadiazine which was oxidised to the 4,4-dioxide. Ethyl 2-nitrophenylsulphonylglyoxylate phenylhydrazone gives only 2-nitrodiphenylamine under these conditions, but reduction to the 2 ...
Donald E. Ames, Sosale Chandrasekhar, Kristian J. Hansen   +2 more
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A Potent New Benzothiadiazine Diuretic

Nature, 1960
SINCE the discovery of chlorothiazide by Beyer et al. 1, a number of chemically related compounds have been shown to possess similar natriuretic and chloruretic actions2–4. Some of these agents, notably 3,4-dihydrochlorothiazide and its derivatives, differ from chlorothiazide primarily in a greater milligram potency, which may be associated with a ...
R M, TAYLOR, M M, WINBURY
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EFFECTS OF BENZOTHIADIAZINES ON SERUM AND TOTAL BODY ELECTROLYTES*

Annals of the New York Academy of Sciences, 1960
P J, TALSO, A J, CARBALLO
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ChemInform Abstract: SYNTHESES OF 1,2,4‐BENZOTHIADIAZINE 1‐OXIDES AND 1,2,4‐BENZOTHIADIAZINES

Chemischer Informationsdienst, 1981
AbstractAus den Anilino‐sulfonylchloriden (I) entstehen mit Natriumsulfit die Sulfinsäuren (II), die mit Thionylchlorid und Aminen (III) zu den Sulfinsäureamiden (IV) führen.
N. FINCH, S. JUN. RICCA, L. H. WERNER, R. RODEBAUGH   +3 more
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Hypotensive Activity of Two Benzothiadiazine Derivatives

Journal of Pharmaceutical Sciences, 1965
4-Hydrazino-1,2,3-benzothiadiazine-1,1 dioxide hydrochloride (EX 4211A) and 6-chloro-3,4-dihydro-3-( β -oxo- n -propyl)-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide phthalazone azine (EX 5004) were studied in the rat and dog to elucidate the mechanism(s) by which these compounds produced hypotensive effects.
A I, EDLIN, W J, KINNARD, E E, VOGIN, J P, BUCKLEY   +3 more
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Production of potassium depletion by benzothiadiazine compounds∗

The American Journal of Cardiology, 1962
Abstract Secondary hyperaldosteronism was simulated in seven patients by the administration of desoxycorticosterone acetate (DCA) in doses of 30 mg. per day. In these patients the sodium-retaining properties of this agent appeared to be independent of total exchangeable sodium.
M A, SACKNER, W D, DAVIDSON, H, SANDBERG, L J, FEINBERG, S, BELLET   +4 more
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The Effect of a Benzothiadiazine, Diazoxide, on Carbohydrate Metabolism

Diabetes, 1964
After the oral, intraperitoneal, or intravenous administration of an antihypertensive, antidiuretic benzothiadiazine, diazoxide, to dogs, rabbits, mice, and rats, rapid hyperglycemia is promptly elicited, but of short duration, and reversible. The hyperglycemia is accompanied by increased hepatic glycogenolysis, serum lactate and pyruvate, and blood ...
I I, TABACHNICK, A, GULBENKIAN, F, SEIDMAN   +2 more
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The hyperglycemic activity of benzothiadiazine and other diuretics

Life Sciences, 1965
Abstract Considerable evidence is available which demontrates the tendency of certain benzothiadiazine diuretics to elevate blood glucose values in seemingly normal, as well as diabetic or pre-diabetic, individuals (1–5). A recent review (5) concerning the benzothiadiazine diuretics suggest that the hyperglycemic potential of all members of this ...
I I, Tabachnick, A, Gulbenkian, A, Yannell   +2 more
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Diuretic Effects of Flumethiazide, a Benzothiadiazine Derivative

Postgraduate Medicine, 1959
Flumethiazide is a potent diuretic agent which may be safely administered to cardiac patients.Both short-term and long-term studies of a large group of patients with congestive heart-failure showed that flumethiazide produced no significant change in the glomerular filtration rate, renal plasma flow or blood pressure.Bio-assay studies revealed that ...
M, FUCHS, S R, MALLIN, S, IRIE, E, LIPPMANN   +3 more
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Structural studies on benzothiadiazine derivatives: 3-amino-4H-1,2,4-benzothiadiazine 1,1-dioxide and 3-hydrazino-4H-1,2,4-benzothiadiazine 1,1-dioxide

Acta Crystallographica Section C Crystal Structure Communications, 1989
C 7 H 7 N 3 O 2 S (1) cristallise dans Cc avec a=14,259, b=22,539 et c=8,741 A, β=114,10 o , Z=12; affinement jusqu'a R=0,040. C 7 H 8 N 4 O 2 S (2) cristallise dans P2 1 /n avec a=6,976, b=8,403 et c=14,748 A, β=90,25 o , Z=4; affinement jusqu'a R=0,042.
G. Bombieri, F. Demartin, D. Braghiroli, S. Todeschi, M. Di Bella   +4 more
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