Results 121 to 130 of about 763 (164)

ChemInform Abstract: SYNTHESES OF 1,2,4‐BENZOTHIADIAZINE 1‐OXIDES AND 1,2,4‐BENZOTHIADIAZINES

Chemischer Informationsdienst, 1981
AbstractAus den Anilino‐sulfonylchloriden (I) entstehen mit Natriumsulfit die Sulfinsäuren (II), die mit Thionylchlorid und Aminen (III) zu den Sulfinsäureamiden (IV) führen.
N. FINCH, S. JUN. RICCA, L. H. WERNER, R. RODEBAUGH   +3 more
openaire   +1 more source

Hypotensive Activity of Two Benzothiadiazine Derivatives

Journal of Pharmaceutical Sciences, 1965
4-Hydrazino-1,2,3-benzothiadiazine-1,1 dioxide hydrochloride (EX 4211A) and 6-chloro-3,4-dihydro-3-( β -oxo- n -propyl)-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide phthalazone azine (EX 5004) were studied in the rat and dog to elucidate the mechanism(s) by which these compounds produced hypotensive effects.
A I, EDLIN, W J, KINNARD, E E, VOGIN, J P, BUCKLEY   +3 more
openaire   +2 more sources

Structural studies on benzothiadiazine derivatives: 3-amino-4H-1,2,4-benzothiadiazine 1,1-dioxide and 3-hydrazino-4H-1,2,4-benzothiadiazine 1,1-dioxide

Acta Crystallographica Section C Crystal Structure Communications, 1989
C 7 H 7 N 3 O 2 S (1) cristallise dans Cc avec a=14,259, b=22,539 et c=8,741 A, β=114,10 o , Z=12; affinement jusqu'a R=0,040. C 7 H 8 N 4 O 2 S (2) cristallise dans P2 1 /n avec a=6,976, b=8,403 et c=14,748 A, β=90,25 o , Z=4; affinement jusqu'a R=0,042.
G. Bombieri, F. Demartin, D. Braghiroli, S. Todeschi, M. Di Bella   +4 more
openaire   +1 more source

�ber tricyclische 1,2,4-Benzothiadiazine

Monatshefte f�r Chemie, 1965
Durch Kondensation von o-Aminobenzolsulfonamid mit Maleinsaureanhydrid wurde das 1-Oxo-1H-pyrrolo[2,1-c] (1,2,4)-benzothiadiazin-5,5-dioxid (I) erhalten. Es wird die Synthese verschiedener Derivate des neuen Ringsystems beschrieben, die zum Teil auch als potentielle Diuretica interessant sind.
K. Katzl, H. Ruis
openaire   +1 more source

Structural studies on benzothiadiazine derivatives: 3-aminomethyl-1,2,4-benzothiadiazine-1,1-dioxide and 6-aminomethyl-3-methyl-1,2,4-benzothiadiazine-1,1-dioxide hydrochloride monohydrate

Journal of Crystallographic and Spectroscopic Research, 1990
The crystal structures of 3-aminomethyl-1,2,4-benzothiadiazine-1, 1-dioxide (1) and 6-aminomethyl-3-methyl-1,2,4-benzothiadiazine-1,1-dioxide hydrochloride monohydrate (2) have been determined by X-ray crystal data. The benzothiadiazine ring is planar in (1), owing to space-group requirements, and almost planar in (2) with the sulfonyl group ...
G. Bombieri, F. Demartin, F. Benetollo, D. Braghiroli, M. Di Bella   +4 more
openaire   +1 more source

Production of potassium depletion by benzothiadiazine compounds∗

The American Journal of Cardiology, 1962
Abstract Secondary hyperaldosteronism was simulated in seven patients by the administration of desoxycorticosterone acetate (DCA) in doses of 30 mg. per day. In these patients the sodium-retaining properties of this agent appeared to be independent of total exchangeable sodium.
M A, SACKNER, W D, DAVIDSON, H, SANDBERG, L J, FEINBERG, S, BELLET   +4 more
openaire   +2 more sources

Benzothiadiazines and Diabetes Mellitus

JAMA, 1964
To the Editor:— Wolff and his associates ( JAMA 185 :568 [Aug 17] 1963) recently indicated that the induction of diabetes mellitus represents a not infrequent complication associated with the long-term administration of benzothiadiazine diuretics. The evidence consisted of the observation that the fasting blood sugar value in 45 patients averaged 97 ...
openaire   +1 more source

Diuretic Effects of Flumethiazide, a Benzothiadiazine Derivative

Postgraduate Medicine, 1959
Flumethiazide is a potent diuretic agent which may be safely administered to cardiac patients.Both short-term and long-term studies of a large group of patients with congestive heart-failure showed that flumethiazide produced no significant change in the glomerular filtration rate, renal plasma flow or blood pressure.Bio-assay studies revealed that ...
M, FUCHS, S R, MALLIN, S, IRIE, E, LIPPMANN   +3 more
openaire   +2 more sources

Spectrophotometric determination of benzothiadiazines in dosage forms

Talanta, 1986
The analytical utility of ethyl acetoacetate for the spectrophotometric determination of benzothiadiazine diuretics has been studied. The procedure developed is based on coupling of the diazotized drugs with the reagent, which possesses an active methylene group. The stoichiometry of the reaction is presented.
F, Belal, M, Rizk, F, Ibrahiem, M S, El-Din   +3 more
openaire   +2 more sources

Synthese mesoionischer 2,1,3‐Benzothiadiazin‐2,2‐dioxide

Liebigs Annalen der Chemie, 1979
AbstractDie mesoionischen 2,1,3‐Benzothiadiazin‐2,2‐dioxide 5 warden spontan aus 2‐Aminobenzalde‐hyd‐dimethylacetal (2) und N‐Alkylamidosulfonylchloriden unter CH3OH‐Abspaltung erhalten. Strukturuntersuchungen mit Hilfe spektroskopischer Methoden ‐ insbesondere der Röntgenphotoelektronenspektroskopie ‐ zeigen eine Lokalisierung der positiven Ladung am ...
Adolf Parg, Gerhard Hamprecht
openaire   +1 more source