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Bioorganic and Medicinal Chemistry Letters, 2007 In continuation of our earlier work on benzothiadiazines, we have prepared a series of nitrofuran, nitrothiophene and arylfuran coupled benzothiadiazines and evaluated them for antimycobacterial and antibacterial activities.
Sandeep Sharma +2 more
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Hypotensive 1,2,4-Benzothiadiazines
Journal of Medicinal Chemistry, 1963B A, BIERBAUM +2 more
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Syntheses of 1,2,4-benzothiadiazine 1-oxides and 1,2,4-benzothiadiazines
Journal of Organic Chemistry, 1980Neville Finch
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Blockade Of The Diuretic Action Of Benzothiadiazines.
, 1966 PhD ; Chemistry ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/184609/2/6708335 ...
Ross, Charles Richard
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Some 1H-4,1,2-benzothiadiazines and 1H-4,1,2-benzothiadiazine 4,4-dioxides
Journal of the Chemical Society, Perkin Transactions 1, 1978Interamolecular displacement of the o-nitro-group of 1-(2-nitrophenylthio)pyruvaldehyde 1-phenylhydrazone, under basic conditions, gives 3-acetyl-1-phenyl-1H-4,1,2-benzothiadiazine which was oxidised to the 4,4-dioxide. Ethyl 2-nitrophenylsulphonylglyoxylate phenylhydrazone gives only 2-nitrodiphenylamine under these conditions, but reduction to the 2 ...
Donald E. Ames +2 more
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A Potent New Benzothiadiazine Diuretic
Nature, 1960SINCE the discovery of chlorothiazide by Beyer et al. 1, a number of chemically related compounds have been shown to possess similar natriuretic and chloruretic actions2–4. Some of these agents, notably 3,4-dihydrochlorothiazide and its derivatives, differ from chlorothiazide primarily in a greater milligram potency, which may be associated with a ...
R M, TAYLOR, M M, WINBURY
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ChemInform Abstract: SYNTHESES OF 1,2,4‐BENZOTHIADIAZINE 1‐OXIDES AND 1,2,4‐BENZOTHIADIAZINES
Chemischer Informationsdienst, 1981AbstractAus den Anilino‐sulfonylchloriden (I) entstehen mit Natriumsulfit die Sulfinsäuren (II), die mit Thionylchlorid und Aminen (III) zu den Sulfinsäureamiden (IV) führen.
N. FINCH +3 more
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Hypotensive Activity of Two Benzothiadiazine Derivatives
Journal of Pharmaceutical Sciences, 19654-Hydrazino-1,2,3-benzothiadiazine-1,1 dioxide hydrochloride (EX 4211A) and 6-chloro-3,4-dihydro-3-( β -oxo- n -propyl)-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide phthalazone azine (EX 5004) were studied in the rat and dog to elucidate the mechanism(s) by which these compounds produced hypotensive effects.
A I, EDLIN +3 more
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