Results 81 to 90 of about 475 (128)

ChemInform Abstract: SYNTHESES OF 1,2,4‐BENZOTHIADIAZINE 1‐OXIDES AND 1,2,4‐BENZOTHIADIAZINES

Chemischer Informationsdienst, 1981
AbstractAus den Anilino‐sulfonylchloriden (I) entstehen mit Natriumsulfit die Sulfinsäuren (II), die mit Thionylchlorid und Aminen (III) zu den Sulfinsäureamiden (IV) führen.
N. FINCH, S. JUN. RICCA, L. H. WERNER, R. RODEBAUGH   +3 more
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The Diabetogenic Activity of Benzothiadiazines

JAMA, 1964
To the Editor:— Because benzothiadiazines have been used so widely for many diverse conditions—including even obesity—any comment on the diabetogenic effect of this class of compounds is important. It is not surprising that a respected senior investigator such as Dr.
Frederick W. Wolff, William W. Parmley
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Hypotensive Activity of Two Benzothiadiazine Derivatives

Journal of Pharmaceutical Sciences, 1965
4-Hydrazino-1,2,3-benzothiadiazine-1,1 dioxide hydrochloride (EX 4211A) and 6-chloro-3,4-dihydro-3-( β -oxo- n -propyl)-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide phthalazone azine (EX 5004) were studied in the rat and dog to elucidate the mechanism(s) by which these compounds produced hypotensive effects.
A I, EDLIN, W J, KINNARD, E E, VOGIN, J P, BUCKLEY   +3 more
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Spectrophotometric determination of benzothiadiazines in dosage forms

Talanta, 1986
The analytical utility of ethyl acetoacetate for the spectrophotometric determination of benzothiadiazine diuretics has been studied. The procedure developed is based on coupling of the diazotized drugs with the reagent, which possesses an active methylene group. The stoichiometry of the reaction is presented.
F, Belal, M, Rizk, F, Ibrahiem, M S, El-Din   +3 more
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The hyperglycemic activity of benzothiadiazine and other diuretics

Life Sciences, 1965
Abstract Considerable evidence is available which demontrates the tendency of certain benzothiadiazine diuretics to elevate blood glucose values in seemingly normal, as well as diabetic or pre-diabetic, individuals (1–5). A recent review (5) concerning the benzothiadiazine diuretics suggest that the hyperglycemic potential of all members of this ...
I I, Tabachnick, A, Gulbenkian, A, Yannell   +2 more
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Benzothiadiazines and Diabetes Mellitus

JAMA, 1964
To the Editor:— Wolff and his associates ( JAMA 185 :568 [Aug 17] 1963) recently indicated that the induction of diabetes mellitus represents a not infrequent complication associated with the long-term administration of benzothiadiazine diuretics. The evidence consisted of the observation that the fasting blood sugar value in 45 patients averaged 97 ...
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Diuretic Effects of Flumethiazide, a Benzothiadiazine Derivative

Postgraduate Medicine, 1959
Flumethiazide is a potent diuretic agent which may be safely administered to cardiac patients.Both short-term and long-term studies of a large group of patients with congestive heart-failure showed that flumethiazide produced no significant change in the glomerular filtration rate, renal plasma flow or blood pressure.Bio-assay studies revealed that ...
M, FUCHS, S R, MALLIN, S, IRIE, E, LIPPMANN   +3 more
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The Effect of a Benzothiadiazine, Diazoxide, on Carbohydrate Metabolism

Diabetes, 1964
After the oral, intraperitoneal, or intravenous administration of an antihypertensive, antidiuretic benzothiadiazine, diazoxide, to dogs, rabbits, mice, and rats, rapid hyperglycemia is promptly elicited, but of short duration, and reversible. The hyperglycemia is accompanied by increased hepatic glycogenolysis, serum lactate and pyruvate, and blood ...
I I, TABACHNICK, A, GULBENKIAN, F, SEIDMAN   +2 more
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Production of potassium depletion by benzothiadiazine compounds∗

The American Journal of Cardiology, 1962
Abstract Secondary hyperaldosteronism was simulated in seven patients by the administration of desoxycorticosterone acetate (DCA) in doses of 30 mg. per day. In these patients the sodium-retaining properties of this agent appeared to be independent of total exchangeable sodium.
M A, SACKNER, W D, DAVIDSON, H, SANDBERG, L J, FEINBERG, S, BELLET   +4 more
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Structural studies on benzothiadiazine derivatives: 3-amino-4H-1,2,4-benzothiadiazine 1,1-dioxide and 3-hydrazino-4H-1,2,4-benzothiadiazine 1,1-dioxide

Acta Crystallographica Section C Crystal Structure Communications, 1989
C 7 H 7 N 3 O 2 S (1) cristallise dans Cc avec a=14,259, b=22,539 et c=8,741 A, β=114,10 o , Z=12; affinement jusqu'a R=0,040. C 7 H 8 N 4 O 2 S (2) cristallise dans P2 1 /n avec a=6,976, b=8,403 et c=14,748 A, β=90,25 o , Z=4; affinement jusqu'a R=0,042.
G. Bombieri, F. Demartin, D. Braghiroli, S. Todeschi, M. Di Bella   +4 more
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