Results 161 to 170 of about 2,731 (212)
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Voltammetric determination of benzoylecgonine
Analytica Chimica Acta, 1999Benzoylecgonine is a metabolyte of cocaine. Benzoylecgonine can be electochemically detected by square-wave voltammetry at a mercury drop electrode in 0.5 mol/L KNO#, at pH 9.2. The maximum response appears at -1.06 V vs. Ag/AgCl/3 M KCl and it depends on benzoylecgonine, the sqare-wave frequency and amplitude, but it is independent of pH solutions ...
Šebojka Komorsky-Lovrić
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The disposition of benzoylecgonine in maternal and fetal rats
Neurotoxicology and Teratology, 2001We tested our hypothesis that pregnancy alters the pharmacokinetic profile of benzoylecgonine, and that this metabolite accumulates in the fetus longer than in the mother. Chronically catheterized near-term pregnant and nonpregnant female Sprague-Dawley rats received an intravenous infusion of benzoylecgonine over a period of 30 min.
Hisayo O Morishima +2 more
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Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves
Phytochemical Analysis, 2002 Extraction of cocaine and benzoylecgonine from coca leaves was performed by focused microwave-assisted extraction (FMAE). Cocaine extraction was optimised with respect to the nature of the extracting solvent, the particle size distribution, the moisture ...
Philippe Christen +2 more
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Cytotoxicity of the cocaine metabolite benzoylecgonine
Brain Research, 1994The NG108-15 and C6 cell lines were used in the present study as neuronal and glial models, respectively, to examine the cytotoxicity of the major metabolite of cocaine, benzoylecgonine (BE). Exposure of both cell types to varying concentrations of BE resulted in a loss of cells from the growth surface.
Y, Lin, K C, Leskawa
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The Analysis of Cocaine and Benzoylecgonine in Meconium
Journal of Analytical Toxicology, 1992We describe an assay for measuring cocaine and benzoylecgonine in meconium of infants born to mothers suspected of using cocaine during their pregnancy. The assay involves the use of fluorescence polarization immunoassay (FPIA) to screen for benzoylecgonine in a methanolic extract of the meconium.
G D, Clark +5 more
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Detection of benzoylecgonine in human urine
Journal of Chromatography A, 1977A thin-layer chromatography (TLC) method is described that can be used to detect benzoylecgonine (BE), a metabolite of cocaine, in human urine. It is a two-part procedure that can be integrated into a rapid screening program for drug abuse. The first part of the method utilizes two TLC solvent systems to identify a variety of drugs, including BE.
M A, Mueller +3 more
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Cocaine and Benzoylecgonine Excretion in Humans
Journal of Forensic Sciences, 1977Abstract Cocaine is rapidly and extensively metabolized. Studies with 3H-labeled cocaine have demonstrated that the drug is biotransformed to at least ten metabolites in the rat, with the concentration of unchanged cocaine in the urine being less than 10% that of the metabolite benzoylecgonine [1].
H E, Hamilton +5 more
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TLC Analysis of Urine for Benzoylecgonine and Norpropoxyphene
Clinical Toxicology, 1980A thin-layer chromatography (TLC) procedure has been developed for the analysis of urine samples for benzoylecgonine and norpropoxyphene, the major metabolites of cocaine and propoxyphene, respectively. Urine is made slightly acidic and methylated with dimethyl sulfate to convert the difficult-to-extract benzoylecgonine back into the much more readily ...
R D, Budd, D F, Mathis, F C, Yang
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Benzoylecgonine exposure induced oxidative stress and altered swimming behavior and reproduction in Daphnia magna [PDF]
Environmental Pollution, 2018 Several monitoring studies have shown that benzoylecgonine (BE) is the main illicit drug residue commonly measured in the aquatic system worldwide. Few studies have investigated the potential toxicity of this molecule towards invertebrate and vertebrate ...
Marco Parolini +2 more
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