Results 1 to 10 of about 67,569 (184)

Data on ethyl glucuronide and cocaethylene concentrations in the hair of cocaine users [PDF]

Data in Brief, 2018
We present data on ethyl glucuronide and cocaethylene concentrations from the hair of cocaine users. Head hair from 64 subjects, previously tested for cocaine, cocaethylene, benzoylecogonine and anhydroecgonine methyl ester (AEME), were subsequently ...
Richard Paul, Lolita Tsanaclis
doaj   +2 more sources

Sex, social rank, and nicotine co-administration shape cocaine- and cocaethylene-induced reinstatement in monkeys [PDF]

Frontiers in Behavioral Neuroscience
IntroductionCocaine use disorder (CUD) is highly comorbid with alcohol and nicotine use, yet preclinical research rarely models polysubstance use or incorporates clinically relevant variables such as social and biological factors.
Brianna F. Roberts, Mia A. Clark, Michael A. Nader, Mia I. Rough   +3 more
doaj   +2 more sources

Cocaethylene : When Cocaine and Alcohol Are Taken Together [PDF]

Cureus, 2022
Cocaine is taken frequently together with ethanol and this combination produces a psychoactive metabolite called cocaethylene which has similar properties to the parent drug and may be more cardiotoxic.
LeQuang, Jo Ann K., Pergolizzi, Joseph, Breve, Frank, Magnusson, Peter, Varrassi, Giustino, LeQuang, Jo Ann K.,, Varrassi, Giustino,, Breve, Frank,, Magnusson, Peter,, Pergolizzi, Joseph,   +9 more
core   +6 more sources

Cocaethylene is more potent than cocaine in mediating lethality

Pharmacology Biochemistry and Behavior, 1991
Cocaethylene is a pharmacologically active cocaine metabolite that is formed in the presence of ethanol by the activity of liver enzymes. The pharmacology of cocaethylene has not been extensively investigated and its acute toxicity is unknown.
W Lee Hearn, Deborah C Mash
exaly   +2 more sources

Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: A pilot study

Pharmacological Research, 2007
Cocaine abusers frequently report taking the drug in association with alcohol. This combined intake leads to the synthesis of cocaethylene, an active metabolite with effects similar to those of cocaine, but more prolonged.
Maria Caterina Grassi, Paolo Nencini
exaly   +2 more sources

Simultaneous determination of ethyl glucuronide, cocaine, cocaethylene, and benzoylecgonine in hair by using LC–MS/MS

Journal of Analytical Science and Technology
Alcohol and cocaine (COC) are commonly co-used drugs that cause addiction and have harmful effects. Their abuse may threaten the health of the abuser and public safety by causing serious accidents or crimes.
Dong Won Shin, Seon Yeong Kim, Sung Ill Suh, Jin Young Kim   +3 more
doaj   +2 more sources

Cardiovascular Risks of Simultaneous Use of Alcohol and Cocaine-A Systematic Review. [PDF]

J Clin Med
Background: The simultaneous use of cocaine and alcohol is highly prevalent and is associated with high numbers of emergency department admissions, primarily due to cardiovascular complications.
van Amsterdam J, Gresnigt F, van den Brink W.   +2 more
europepmc   +3 more sources

Mecanismos de cardiotoxicidad: antineoplásicos, anti-inflamatorios no esteroideos, antipsicóticos, cocaetileno y simpaticomiméticos Mechanisms of cardiotoxicity: antineoplastics, nonsteroidal anti-inflammatory drugs, antipsychotics, cocaethylene and sympathomimetics

Revista Colombiana de Cardiología, 2011
La interacción constante del organismo humano con diferentes sustancias, que incluso en muchas ocasiones se consideran inofensivas, tiene un alto impacto sobre todos los sistemas, siendo el cardiovascular uno de los más afectados.
Lukas Salazar, Ana Cristina Palacio, Javier R Rodríguez   +2 more
doaj   +1 more source

Validation of a method for simultaneous analysis of cocaine, benzoylecognine and cocaethylene in urine using gas chromatography-mass spectrometry

Brazilian Journal of Pharmaceutical Sciences, 2021
The present study describes a method for simultaneous analysis of cocaine, benzoylecgonine and cocaethylene in urine samples. After solid phase extraction, Gas Chromatography-Mass Spectrometry was used for identification and quantification.
Vinicius Stela Menotti, Deborah Thais Palma Scanferla, Kleber Ota de Oliveira, Gabriela Felber Fratucci, Gessé de Souza Alves, Erika Bando, Samuel Botião Nerilo, Magda Lúcia Félix de Oliveira, Miguel Machinski Junior, Simone Aparecida Galerani Mossini   +9 more
doaj   +1 more source

Tyrosine nitration of a humanized anti-cocaine mAb differentially affects ligand binding of cocaine and its metabolites

Biochemistry and Biophysics Reports, 2022
Tetranitromethane was used to selectively modify tyrosine residues of a humanized anti-cocaine mAb (h2E2), under development for the treatment of cocaine use disorders.
Terence L. Kirley, Kenneth D. Greis, Andrew B. Norman   +2 more
doaj   +1 more source