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Is there a relationship between abuse of alcohol and illicit drugs seen in hair results? [PDF]

Drug Test Anal
Abstract Combined use of alcohol and illicit drugs is a serious health and social problem. In this study, it was examined, whether a relationship between alcohol and drug abuse can be ascertained by comparison of alcohol marker and drug concentrations in hair.
Pragst F, Niebel A, Thurmann D, Dullin M, Eichberg S, Mörlein F, Hartwig S.   +6 more
europepmc   +2 more sources

Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption

Molecules, 2020
Reliable, feasible analytical methods are needed for forensic and anti-doping testing of cocaine and its most important metabolites, benzoylecgonine, ecgonine methyl ester, and cocaethylene (the active metabolite formed in the presence of ethanol).
Roberto Mandrioli, Laura Mercolini, Michele Protti   +2 more
doaj   +1 more source

Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity

Human Vaccines & Immunotherapeutics, 2023
A humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disorder.
Rose P. Webster, Jordan A. Marckel, Andrew B. Norman   +2 more
doaj   +1 more source

Effects of alcohol on metabolism and toxicity of cocaine in rats

Toxicology Reports, 2022
As most cocaine users drink alcohol, it is interesting to understand how a non-lethal dose of alcohol affects the metabolism and toxicity of cocaine.
Linyue Shang, Xirong Zheng, Ting Zhang, Jing Deng, Chang-Guo Zhan, Fang Zheng   +5 more
doaj   +1 more source

Analysis of Drugs in Saliva of US Military Veterans Treated for Substance Use Disorders Using Supported Liquid Extraction and Surface-Enhanced Raman Spectral Analysis

Molecules, 2023
According to the Center for Disease Control, there were more than 107,000 US drug overdose deaths in 2021, over 80,000 of which due to opioids. One of the more vulnerable populations is US military veterans.
Stuart Farquharson, Chetan Shende, Jenelle Newcomb, Ismene L. Petrakis, Albert J. Arias   +4 more
doaj   +1 more source

Stability of Cocaine, Opiates, and Metabolites in Dried Saliva Spots

Molecules, 2022
Drug abuse still represents a global problem, and it is associated with an increased risk of diseases, injuries, and deaths. Cocaine (COC) and opiates are the most abused drugs and account for a significant number of fatalities.
Ema Almeida, Sofia Soares, Joana Gonçalves, Tiago Rosado, Nicolás Fernández, Jesus M. Rodilla, Luís A. Passarinha, Mário Barroso, Eugenia Gallardo   +8 more
doaj   +1 more source

Evaluation of ethylglucuronide and cocaethylene as hair markers of alcohol consumption

Clinica Chimica Acta
Background and aims: The concurrent use of alcohol and cocaine is known to be a harmful condition in terms of behaviour and organ damage. The identification of this condition requires the use of objective biomarkers, such as hair ethylglucuronide (hEtG ...
Bertaso, A, Porpiglia, N M, Casini, C, Gottardo, R, Canal, L, Micciolo, R, Pesavento, S, Mazzola, M, Bortolotti, F, Tagliaro, F   +9 more
core   +5 more sources

Concurrent use of alcohol and cocaine: which is the best drug choice?

European Psychiatry, 2022
Introduction Patients with comorbid cocaine and alcohol dependence have a worse prognosis with lack of adherence to follow-up and treatment, frequent psychosocial problems, and higher rates of relapse [1].
H. Becerra Darriba
doaj   +1 more source

Cocaethylene synthesis in Drosophila

Neuroscience Letters, 1999
Cocaethylene is an active cocaine metabolite that targets mammalian neural reward pathways and thus contributes to the reinforcing and addictive properties of ethanol and cocaine. Using gas chromatography-mass spectrometry, we find that fruit flies (Drosophila melanogaster) possess a cellular mechanism through which cocaine can be converted to ...
Judith M Horowitz, German Torres
core   +3 more sources

Degradation of Cocaine and Benzoylecgonine in Sewage Sludge Batch Tests

Fountain Journal of Natural and Applied Sciences (FUJNAS), 2017
The degradation studies of cocaine and its principal metabolites, benzoylecgonine, as emerging pollutants were carried out using various sludge types collected from the RAF Molesworth Sewage Treatment Work (STW) to determine their distribution and ...
A. O. Mustapha, C. Michael, W. B. Jason
doaj   +3 more sources