Results 31 to 40 of about 67,569 (184)
Exploring e-psychonauts perspectives towards cocaine effects and toxicity
Substance Abuse Treatment, Prevention, and Policy, 2022 Background According to the World Drug Report, cocaine is the second most used drug globally after cannabis. Online discussion forums enable the understanding of authentic drug users’ experience as it is anonymous.
Sulaf Assi +2 more
doaj +1 more source
Molecules, 2015 The illegal use of opiates and cocaine is a challenge world-wide, but some derivatives are also valuable pharmaceuticals. Reference samples of the active ingredients and their metabolites are needed both for controlling administration in the clinic and ...
Morten Karlsen +3 more
doaj +1 more source
Cocaine- and Cocaethylene-Creatinine Clearance Ratios in Humans [PDF]
Journal of Analytical Toxicology, 1997 Cocaine (COC)- and cocaethylene (CE)-creatinine clearance ratios (CCR) were determined in five patients. In each case, COC:CCR greatly exceeded CE:CCR, and in four patients the data suggested renal tubular secretion of COC. For all patients, some renal tubular reabsorption of CE was apparent.
D N, Bailey, J B, Bessler, B A, Sawrey
openaire +2 more sources
, 2020 The present study describes a method for simultaneous analysis of cocaine, benzoylecgonine and cocaethylene in urine samples. After solid phase extraction, Gas Chromatography-Mass Spectrometry was used for identification and quantification.
Gabriela Felber Fratucci (12848972) +9 more
core +1 more source
Cocaine and Cocaethylene Binding to Human Liver [PDF]
Journal of Analytical Toxicology, 1998 The binding of cocaine (COC) and cocaethylene (CE) to whole human liver homogenates in vitro was studied by equilibrium dialysis. Drugs were measured by high-pressure liquid chromatography. Up to 32% of COC and up to 43% of CE were bound. Scatchard analysis suggested a high-affinity, low-capacity binder for both COC (Ka, 4.69 x 10(4) L/mol; Bo, 1.08 x ...
openaire +2 more sources
Cocaethylene: A Unique Cocaine Metabolite Displays High Affinity for the Dopamine Transporter
, 1991 : Concurrent cocaine and alcohol use is common practice in the general population, as indicated by recent prevalence studies. In the presence of ethyl alcohol, cocaine is metabolized to its ethyl homolog, cocaethylene.
Wetli, Charles V +7 more
core +1 more source
Journal of Forensic Sciences, EarlyView.Abstract Hair analysis is a well‐established matrix in forensic toxicology, offering a valuable alternative or complement to traditional matrices in diverse contexts, including drug‐facilitated crimes (DFC), elder abuse, and accidental exposure in children.
Amandine Fort +8 more
wiley +1 more source
Addiction, EarlyView.Abstract Aim To monitor community‐level consumption of 20 illicit drugs across urban areas of England using wastewater‐based epidemiology (WBE) surveillance at high temporal resolution. Design, setting, cases This study was conducted over a 12‐month period in 2022 sampling 24‐hour composite wastewater samples at 15 wastewater treatment plants (WWTPs ...
Helena Rapp‐Wright +14 more
wiley +1 more source
Drug Testing and Analysis, Volume 18, Issue 6, Page 771-776, June 2026.Permanent chemical hair straightening was associated with analyte‐dependent changes in hair concentrations, showing increased endogenous GHB levels and decreased alprazolam concentrations after treatment. These results suggest that chemical hair straightening procedures may influence hair concentrations and should be considered when interpreting hair ...
Miriam Blanco‐Ces +5 more
wiley +1 more source
TV-1380 attenuates cocaine-induced changes in cardiodynamic parameters in monkeys and reduces the formation of cocaethylene [PDF]
, 2018 Background: TV-1380 is a rationally mutated, human BChE fused to human serum albumin that has high hydrolytic enzymatic activity against cocaine and as well as an extended elimination half-life.
Hussein Hallak +9 more
core +1 more source