Results 11 to 20 of about 67,744 (195)

Factors Associated With Cocaine Use Disorder: Results From the French Nationwide Repeated Cross-Sectional OPPIDUM Study (2019-2023). [PDF]

Fundam Clin Pharmacol
ABSTRACT Cocaine use has increased both globally and nationally. This trend is accompanied by a rise in clinical complications. The objective of our study was to identify factors observed to be associated with cocaine use disorder, using data from the OPPIDUM program, collecting information directly from patients with substance use disorders recruiting
Alhamidi Z, Lacroix C, Jouve E, Soeiro T, Eiden C, Micallef J.   +5 more
europepmc   +2 more sources

Is there a relationship between abuse of alcohol and illicit drugs seen in hair results? [PDF]

Drug Test Anal
Abstract Combined use of alcohol and illicit drugs is a serious health and social problem. In this study, it was examined, whether a relationship between alcohol and drug abuse can be ascertained by comparison of alcohol marker and drug concentrations in hair.
Pragst F, Niebel A, Thurmann D, Dullin M, Eichberg S, Mörlein F, Hartwig S.   +6 more
europepmc   +2 more sources

Cocaine: An Updated Overview on Chemistry, Detection, Biokinetics, and Pharmacotoxicological Aspects including Abuse Pattern

Toxins, 2022
Cocaine is one of the most consumed stimulants throughout the world, as official sources report. It is a naturally occurring sympathomimetic tropane alkaloid derived from the leaves of Erythroxylon coca, which has been used by South American locals for ...
Rita Roque Bravo, Ana Carolina Faria, Andreia Machado Brito-da-Costa, Helena Carmo, Přemysl Mladěnka, Diana Dias da Silva, Fernando Remião, on behalf of The OEMONOM Researchers   +7 more
doaj   +1 more source

Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption

Molecules, 2020
Reliable, feasible analytical methods are needed for forensic and anti-doping testing of cocaine and its most important metabolites, benzoylecgonine, ecgonine methyl ester, and cocaethylene (the active metabolite formed in the presence of ethanol).
Roberto Mandrioli, Laura Mercolini, Michele Protti   +2 more
doaj   +1 more source

Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity

Human Vaccines & Immunotherapeutics, 2023
A humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disorder.
Rose P. Webster, Jordan A. Marckel, Andrew B. Norman   +2 more
doaj   +1 more source

Effects of alcohol on metabolism and toxicity of cocaine in rats

Toxicology Reports, 2022
As most cocaine users drink alcohol, it is interesting to understand how a non-lethal dose of alcohol affects the metabolism and toxicity of cocaine.
Linyue Shang, Xirong Zheng, Ting Zhang, Jing Deng, Chang-Guo Zhan, Fang Zheng   +5 more
doaj   +1 more source

Analysis of Drugs in Saliva of US Military Veterans Treated for Substance Use Disorders Using Supported Liquid Extraction and Surface-Enhanced Raman Spectral Analysis

Molecules, 2023
According to the Center for Disease Control, there were more than 107,000 US drug overdose deaths in 2021, over 80,000 of which due to opioids. One of the more vulnerable populations is US military veterans.
Stuart Farquharson, Chetan Shende, Jenelle Newcomb, Ismene L. Petrakis, Albert J. Arias   +4 more
doaj   +1 more source

Stability of Cocaine, Opiates, and Metabolites in Dried Saliva Spots

Molecules, 2022
Drug abuse still represents a global problem, and it is associated with an increased risk of diseases, injuries, and deaths. Cocaine (COC) and opiates are the most abused drugs and account for a significant number of fatalities.
Ema Almeida, Sofia Soares, Joana Gonçalves, Tiago Rosado, Nicolás Fernández, Jesus M. Rodilla, Luís A. Passarinha, Mário Barroso, Eugenia Gallardo   +8 more
doaj   +1 more source

Concurrent use of alcohol and cocaine: which is the best drug choice?

European Psychiatry, 2022
Introduction Patients with comorbid cocaine and alcohol dependence have a worse prognosis with lack of adherence to follow-up and treatment, frequent psychosocial problems, and higher rates of relapse [1].
H. Becerra Darriba
doaj   +1 more source

Effects of cocaethylene on dopamine and serotonin synthesis in Long–Evans and Sprague–Dawley brains [PDF]

, 1998
We examined the behavioral and neurochemical effects of cocaethylene treatment in Long–Evans ( LE). and Sprague–Dawley (SD) rats. Cocaethylene-induced behaviors were significantly less in LE rats.
Baumann, Dr. M.H., Horowitz, Dr. J.M., Kristal, Dr. M.B., Torres, Dr. G.   +3 more
core   +1 more source