Results 1 to 10 of about 2,731 (212)
Rapid Determination of Cocaine and Its Metabolite Benzoylecgonine in Hair by LC-MS/MS [PDF]
Fayixue Zazhi, 2018 Objective To establish a rapid determination method with LC-MS/MS for cocaine and its metabolite benzoylecgonine in hair. Methods Deuterated internal standards （cocaine-D3 and benzoylecgonine-D8） were added to the decontaminated hair.
PAN Mei-ru, QIANG Huo-sheng, SHEN Bao-hua,et al.
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Synthesis and characterization of a functional benzoylecgonine – bovine serum albumin conjugate for quantification of a humanized monoclonal anti-cocaine antibody [PDF]
Biochemistry and Biophysics ReportsWe have developed a humanized monoclonal anti-cocaine antibody (h2E2), as a potential solution for cocaine use disorder. A key milestone was the development of an assay to quantify this monoclonal antibody (mAb) in animal and human blood.
Rose P. Webster +4 more
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Analysis of crude wastewater from two treatment plants in South Wales for 35 new psychoactive substances and cocaine, and cannabis [PDF]
Scientific ReportsThis study investigates the presence of new psychoactive substances (NPS) and their metabolites in two wastewater treatment plants (WWTPs) situated in South Wales, UK (WWTP-1 and WWTP-2).
Bethan Davies +3 more
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LC-QToF-MS Analysis of Stimulant Drugs and Their Metabolites in Wastewater During Football Games [PDF]
MetabolitesBackground: The use of illicit drugs and stimulants is a burgeoning socioeconomic problem, ultimately leading to an increase in street crimes and deteriorating human health.
Brandon J. Stamper +7 more
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Brazilian Journal of Pharmaceutical Sciences, 2021 The present study describes a method for simultaneous analysis of cocaine, benzoylecgonine and cocaethylene in urine samples. After solid phase extraction, Gas Chromatography-Mass Spectrometry was used for identification and quantification.
Vinicius Stela Menotti +9 more
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Biochemistry and Biophysics Reports, 2022 Tetranitromethane was used to selectively modify tyrosine residues of a humanized anti-cocaine mAb (h2E2), under development for the treatment of cocaine use disorders.
Terence L. Kirley +2 more
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Impact of Quantisal® Oral Fluid Collection Device on Drug Stability
Frontiers in Toxicology, 2021 The stability of drugs can affect drug tests and interpretations. A comprehensive study to verify drug stability in Quantisal® oral fluid (OF) collection device was undertaken in accordance with Australian standard, AS/NZS 4760:2019 (SAI-Global, 2019 ...
Michela Riggio +4 more
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AN OPTIMIZED GC-MS METHOD FOR IDENTIFICATION OF COCAINE AND ITS MAJOR METABOLITES [PDF]
Journal of IMAB, 2017 Purpose: To develop a simple yet sensitive, reliable and robust method for qualitative determination of cocaine and a series of its tropane metabolites in biological samples (blood, urine, etc.).
Georgi Bonchev
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Química Nova, 2021 This study aimed to investigate a miniaturized extraction methodology with analysis by GC-MS for simultaneous detection and quantification of cocaine (COC), benzoylecgonine (BZE) and cocaethylene (CE) in hair to monitor drug addicts. The process was done
Deborah Thais Palma Scanferla +11 more
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Molecules, 2020 Reliable, feasible analytical methods are needed for forensic and anti-doping testing of cocaine and its most important metabolites, benzoylecgonine, ecgonine methyl ester, and cocaethylene (the active metabolite formed in the presence of ethanol).
Roberto Mandrioli +2 more
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