Results 11 to 20 of about 2,731 (212)

Radioimmunoassay of benzoylecgonine in samples of forensic interest

Journal of Pharmacy and Pharmacology, 1984
Abstract A simple and economical radioimmunoassay for benzoylecgonine in blood or urine is described. Haemolysis, decomposition, common anticoagulants and sodium fluoride do not affect the results. A commercially available antiserum is used at a dilution of 1:600. The tracer is radioiodinated p-hydroxybenzoylecgonine.
K, Robinson, R N, Smith
openaire   +3 more sources

DETERMINATION OF COCAINE AND BENZOYLECGONINE IN BIOLOGICAL MATRICES BY HPLC AND LC-MS/MS.

Journal of the Turkish Chemical Society, Section A: Chemistry, 2016
Cocaine is a powerfully addictive illicit drug. Cocaine abuse and addiction continue to increase in the world. Most analytical tests for the detection of cocaine use include the analysis of the metabolite, benzoylecgonine, in the urine.
Zinar Pinar GUMUS, Veysel Umut Celenk, Emine Guler, Bilal Demir, Hakan Coskunol, Suna Timur   +5 more
doaj   +2 more sources

Determination of cocaine and benzoylecgonine in nails by liquid chromatography-electrospray ionization-tandem mass spectrometry

Archives of Forensic Medicine and Criminology, 2015
Nails and hair are a biological matrix which can be analyzed to confirm the use of a xenobiotic even several months after intake. Results of nail analysis can be used, for example, as evidence in civil and criminal law cases in which a history of drug ...
Marzena Sykutera, Przemysław Piotrowski, Elżbieta Bloch-Bogusławska   +2 more
doaj   +2 more sources

Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine

Scientific Reports, 2023
Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocaine to ...
Linyue Shang, Zhenyu Jin, Huimei Wei, Shawn Park, Chang-Guo Zhan, Fang Zheng   +5 more
doaj   +2 more sources

Detection of cocaine and benzoylecgonine in formalin fixed rat tissues

Toxicology Mechanisms and Methods, 2009
The stability of drugs in formalin solution is an important factor in forensic investigation. Tissues (liver, lung, kidney, brain) taken from rats, which have been poisoned acutely with cocaine, were preserved in two different conditions, analyzed by GC-MS, and then compared.
Hilal, Ahmet, Daglioglu, Nebile, Battal, Dilek, Yener, Fadile, Daglioglu, Kenan   +4 more
core   +4 more sources

Degradation of Cocaine and Benzoylecgonine in Sewage Sludge Batch Tests

Fountain Journal of Natural and Applied Sciences (FUJNAS), 2017
The degradation studies of cocaine and its principal metabolites, benzoylecgonine, as emerging pollutants were carried out using various sludge types collected from the RAF Molesworth Sewage Treatment Work (STW) to determine their distribution and ...
A. O. Mustapha, C. Michael, W. B. Jason
doaj   +5 more sources

The Predictive Value of Emotion Regulation in Cocaine Use Disorder Severity: Psychotherapeutic Implications During Hospitalization for Detoxification. [PDF]

Clin Psychol Psychother
ABSTRACT Objective Traditional treatment approaches in cocaine use disorder (CUD) still report high rates of poor outcomes. Emotion regulation (ER) is a transdiagnostic factor that may contribute to the initiation and maintenance of CUD, strengthening addiction severity. A deeper understanding of ER in this population is crucial for improving treatment
Palazón-Llecha A, Trujols J, Madre M, Duran-Sindreu S, Batlle F, Mallorquí-Bagué N.   +5 more
europepmc   +2 more sources

Post-Mortem Identification and Toxicological Findings of Fluetonitazepyne and Isotonitazepyne. [PDF]

Drug Test Anal
In early 2025, five death cases in Finland tested positive for fluetonitazepyne and one for isotonitazepyne in urine drug screening. A peak corresponding to O‐dealkylated fluetonitazepyne, the 4‐OH‐nitazepyne metabolite, was present in all fluetonitazepyne‐positive urine samples and was later used in the identification of isotonitazepynein one fatal ...
Kriikku P, Pelander A, Jylhä A, Ojanperä I.   +3 more
europepmc   +2 more sources

Traces of Use: Uncovering Drug Use Insights From Paraphernalia Analysis. [PDF]

Drug Alcohol Rev
ABSTRACT Introduction The residue analysis of disposed paraphernalia from people who inject drugs is a novel way to discern drug taking behaviours. This study aimed to investigate the presence of conventional and novel psychoactive substances (NPS) in drug paraphernalia in South Australia.
Keller EL, Peake B, Simpson BS, Longo M, White JM, Gerber C.   +5 more
europepmc   +2 more sources

Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine [PDF]

ACS Chemical Biology, 2016
Cocaine is one of the most addictive drugs without a U.S. Food and Drug Administration (FDA)-approved medication. Enzyme therapy using an efficient cocaine-metabolizing enzyme is recognized as the most promising approach to cocaine overdose treatment.
Xiabin, Chen, Xirong, Zheng, Max, Zhan, Ziyuan, Zhou, Chang-Guo, Zhan, Fang, Zheng   +5 more
openaire   +2 more sources