Results 51 to 60 of about 73,329 (193)

Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells [PDF]

International Journal of Cancer, 2006
Abstract In the present study, experiments using presynchronization culture cells demonstrated that benzyl ITC (BITC), previously isolated from a tropical papaya fruit extract, induced the cytotoxic effect preferentially in the proliferating human colon CCD‐18Co cells to the quiescent ones.
Noriyuki, Miyoshi, Koji, Uchida, Toshihiko, Osawa, Yoshimasa, Nakamura   +3 more
openaire   +2 more sources

Stability of Benzylic-Type Isothiocyanates in Hydrodistillation-Mimicking Conditions

Journal of Agricultural and Food Chemistry, 2012
Pentadiplandra brazzeana Baillon (Pentadiplandraceae) is known to contain benzyl-, 3-methoxybenzyl-, 4-methoxybenzyl-, 3,4-dimethoxybenzyl-, and indole-type glucosinolates, and the essential oil obtained from its roots is mainly constituted of benzyl isothiocyanate and benzyl cyanide.
De Nicola, Gina R., Montaut, Sabine, Rollin, Patrick, Nyegue, Maximilienne, Menut, Chantal, Iori, Renato, Tatibouët, Arnaud   +6 more
openaire   +3 more sources

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

The Potential of Plant Secondary Metabolites as Bread Mould Inhibitors: Exploring Their Individual and Combined Antifungal Effect

Foods
Plant secondary metabolites are an interesting source of natural antifungals and offer an alternative to synthetic preservatives. In this study, the activity of 218 secondary metabolites was evaluated against nine Penicillium species and one Aspergillus ...
Amber Lepoutre, Els Debonne, Wouter Van Genechten, Serena Martini, Patrick Van Dijck, Frank Devlieghere   +5 more
doaj   +1 more source

GLC–MS analysis of the volatile compounds of turnip and radish root crops [PDF]

Brazilian Journal of Biology
This paper presents an analysis of the volatile compounds isolated from the roots of turnip Brassica rapa L. ‘Petrovskaya 1’ and from the roots of the Chinese subspecies of radish Raphanus sativus subsp. sinensis Sinsk.
O. V. Eliseeva, B. A. Borisov, O. E. Efimov   +2 more
doaj   +2 more sources

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Molecules, 2020
Moringa oleifera Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate (
Gigliola Borgonovo, Luciano De Petrocellis, Aniello Schiano Moriello, Simona Bertoli, Alessandro Leone, Alberto Battezzati, Stefania Mazzini, Angela Bassoli   +7 more
doaj   +1 more source

Identification and improvement of isothiocyanate-based inhibitors on stomatal opening to act as drought tolerance-conferring agrochemicals

Nature Communications, 2023
Stomatal pores in the plant epidermis open and close to regulate gas exchange between leaves and the atmosphere. Upon light stimulation, the plasma membrane (PM) H+-ATPase is phosphorylated and activated via an intracellular signal transduction pathway ...
Yusuke Aihara, Bumpei Maeda, Kanna Goto, Koji Takahashi, Mika Nomoto, Shigeo Toh, Wenxiu Ye, Yosuke Toda, Mami Uchida, Eri Asai, Yasuomi Tada, Kenichiro Itami, Ayato Sato, Kei Murakami, Toshinori Kinoshita   +14 more
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Physicochemical and Enzymatic Properties of Benzyl Isothiocyanate Derivatized Proteinases

, 2016
This paper deals with interactions of benzyl isothiocyanate (benzyl-ITC) with cysteine proteases (bromelain and papain) as well as with serine proteases (trypsin and α-chymotrypsin).
Harshadrai M. Rawel (2682847), Jürgen Kroll (2682850), Sophie Haebel (60338), Brigitte Riese-Schneider (3009867)   +3 more
core   +1 more source

Katalytischer Schwefelatomtransfer vermittelt durch einen Bis(disulfido)‐Titankomplex

Angewandte Chemie, EarlyView.
Mehrelektronentransformationen mit Titan sind aufgrund der limitierten Zugänglichkeit niedervalenter Vorstufen bislang nur unzureichend untersucht. Die Vier‐Elektronen‐Aktivierung von elementarem Schwefel durch einen Ti(IV)‐Komplex führt zu einem seltenen Bis(disulfido)‐Titankomplex, der die effiziente katalytische Synthese von Isothiocyanaten aus ...
Sebastian Samir Cremer, Peter Coburger, Corinna Czernetzki, Gabriele Hierlmeier   +3 more
wiley   +1 more source