Results 41 to 50 of about 73,329 (193)

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie, EarlyView.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +2 more sources

Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Glutathione reductase (GR), an essential antioxidant enzyme against oxidative stress, has become an attractive drug target for the development of anticancer and antimalarial drugs.
Xia Li, Maowei Ni, Xiaoling Xu, Wei Chen
doaj   +1 more source

Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells. [PDF]

PLoS ONE, 2012
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of breast cancer cells but the mechanisms underlying growth inhibitory effect of BITC are not fully understood.
Dong Xiao, Ajay Bommareddy, Su-Hyeong Kim, Anuradha Sehrawat, Eun-Ryeong Hahm, Shivendra V Singh   +5 more
doaj   +1 more source

Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent [PDF]

Mutagenesis, 1999
Benzyl isothiocyanate (BITC) is contained in cruciferous plants which are part of the human diet. Numerous reports indicate that BITC prevents chemically induced cancer in laboratory animals and it has been postulated that BITC might also be chemoprotective in humans.
F, Kassie, B, Pool-Zobel, W, Parzefall, S, Knasmüller   +3 more
openaire   +2 more sources

Effects of intraspecific variation in white cabbage (brassica oleracea var. Capitata) on soil organisms [PDF]

, 2010
Contains fulltext : 84267.pdf (Publisher’s version ) (Closed access)20 ...
Dam, N.M., van, Van Dam, N.M., Biere, A., Patrick Kabouw, Van der Putten, W.H., Kabouw, P., Putten, W.H., van der, Dam, N.M. van, Nicole M. van Dam, Arjen Biere, Wim H. van der Putten, Putten, W.H. van der   +11 more
core   +3 more sources

Quantitative and Qualitative Analysis of and Seeds by UPLC-DAD and UPLC-ESI-QTOF

Natural Product Communications, 2017
Eruca sativa and Brassica juncea belong to the Brassicaceae family and have been used traditionally for the treatment of cancer and various cardiovascular ailments.
Arti Sharma, Ritika Sharma, Rohit Arora, Saroj Arora, Bikram Singh, Upendra Sharma   +5 more
doaj   +1 more source

Synthesis, crystal structure, and optical properties of benzyl isoquinolinium dibromo-bis(isothiocyanate)zinc(II)

, 2022
The title inorganic-organic hybrid material containing a mixed anion, [BzIQl]2[Zn(NCS)2Br2] (1) (BzIQl = benzyl isoquinolinium, NCS− = isothiocyanate), crystallizes with a benzyl isoquinolinium cation and half of a bis(bromo)-bis(isothiocyanate)zinc(II ...
Yi-Lin Xu (12280540), Yan-Lin Chen (6107081), Wen-Xu Zheng (2935161), Yu Cai (112178), Jia-Yu Yu (8106680), Ke-Lai Chen (12280537), Yong-Zhen He (12280543), Chun-Lin Ni (8712855), Ke Yin (2027935)   +8 more
core   +1 more source

In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells [PDF]

Vojnosanitetski Pregled, 2016
Background/Aim. Numerous epidemiological studies have shown beneficial effects of cruciferous vegetables consumption in cancer chemoprevention.
Konić-Ristić Aleksandra, Stanojković Tatjana, Srdić-Rajić Tatjana, Dilber Sanda, Đorđević Brižita, Stanković Ivan, Juranić Zorica   +6 more
doaj   +1 more source

Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity

Molecules, 2022
For decades, various plants have been studied as sources of biologically active compounds. Compounds with anticancer and antimicrobial properties are the most frequently desired.
Łukasz Janczewski
doaj   +1 more source

ynthesis and Characterization of 1-Aryl-5-hepta-O-acetyl-β-D-maltosyl-2-S-benzyl-2,4-isodithiobiurets

E-Journal of Chemistry, 2012
The facile synthesis of 1-aryl-5-hepta-o-acetyl-β-D-maltosyl-2-S-benzyl-2,4-isodithiobiurets (IIIa-g) has been achieved by the interaction of 1-hepta-O-acetyl-β–D-maltosyl isothiocyanate (I) with various1-aryl-S-benzyl isothiocarbamides (IIa-g). All the
R. D. Ghuge, S. P. Deshmukh
doaj   +1 more source