Results 71 to 80 of about 60,745 (143)

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Chitosan–Alginate Polyelectrolyte Systems: From Classical Release Models to the D‐PARMO Framework

Macromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.
Classical empirical models fail to predict the dynamic in vivo behavior of chitosan‐alginate nanocarriers. Bridging this translational gap, the novel D‐PARMO framework replaces purely descriptive curve‐fitting with a mechanistically informed operational model.
Parastoo Rekab, Akeem Adeyemi Oladipo
wiley   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

Investigation of Kidney Histopathology in Rats Receiving Methamphetamine Simultaneously with Berberine Hydrochloride and Aerobic Exercise [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Given the widespread issue of methamphetamine addiction and its damaging effects, coupled with the crucial role of the kidneys in maintaining bodily equilibrium, we chose to undertake this study.
Danial Naghipour, Aref Arminfar, Zahra Sahraneshin Samani, Lida Sepanloo, Hessamedin Babaei, Mohammad Hossein Hasani, Behrooz Yahyaei   +6 more
doaj  

Characterization of carbapenem-resistant Klebsiella pneumoniae in bloodstream infections: antibiotic resistance, virulence, and treatment strategies

Frontiers in Cellular and Infection Microbiology
BackgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) infections pose a major clinical challenge due to multidrug resistance. This study evaluated the clinical features, antibiotic resistance mechanisms, virulence factors, and the potential ...
Chenglin Zhong, Shaohua Lin, Zeqi Li, Xuejing Yang   +3 more
doaj   +1 more source

Integrative Use of Ningmitai Capsule and Cefoxitin in Treating Post‐Ureteroscopic Lithotripsy Stent‐Related Urinary Tract Infections

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
Clinical Value of Ningmitai Capsule Combined with Cefoxitin in the Management of UTI Following URL with Stent Placement Based on Logistic Regression and DCA. ABSTRACT Ureteral stent placement following ureteroscopic lithotripsy (URL) reduces obstruction but increases the risk of urinary tract infection (UTI).
Gang Chen, Jun Zhou
wiley   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, Volume 13, Issue 21, 13 April 2026.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Electrospun lipid-coated medicated nanocomposites for an improved drug sustained-release profile

Materials & Design, 2019
Nanotechnology has been extensively explored for the potential applications in developing materials for sustained drug release. In this study, a modified coaxial electrospinning, characterized by a detachable concentric spinneret, was developed for the ...
Tao Hai, Xi Wan, Deng-Guang Yu, Ke Wang, Yaoyao Yang, Zhe-Peng Liu   +5 more
doaj   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, Volume 13, Issue 21, 13 April 2026.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Evaluation of Drugs with Therapeutic Potential for Susceptibility of Neisseria Gonorrhoeae Isolates from 8 Provinces in China from 2018

Infection and Drug Resistance, 2020
Xiao-Li Zheng,1,2 Wen-Qi Xu,1,2 Jing-Wei Liu,1,2 Xiao-Yu Zhu,1,2 Shao-Chun Chen,1,2 Yan Han,1,2 Xiu-Qin Dai,1,2 Isabelle Griffin Goodman,3 Christoph Budjan,4,5 Xiang-Sheng Chen,1,2 Yue-Ping Yin1,2 1Institute of Dermatology and Hospital for Skin Diseases,
Zheng XL, Xu WQ, Liu JW, Zhu XY, Chen SC, Han Y, Dai XQ, Goodman IG, Budjan C, Chen XS, Yin YP   +10 more
doaj