Results 51 to 60 of about 3,815,474 (195)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Best approximation in spaces with asymmetric norm
Journal of Numerical Analysis and Approximation Theory, 2006 In this paper we shall present some results on spaces with asymmetric seminorms, with emphasis on best approximation problems in such spaces.
Ştefan Cobzaş, Costică Mustăţa
doaj +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Best multiplier Approximation in L_(p,∅_n ) (B)
Al-Mustansiriyah Journal of Science, 2019 The purpose of this paper is to find best multiplier approximation of unbounded functions in L_(p,∅_n ) –space by using Trigonometric polynomials and by de la Vallee- Poussin operators.
Saheb K. Al-Saidy +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Best approximation for nonconvex set in $q$-normed space [PDF]
, 2006 summary:Some existence results on best approximation are proved without starshaped subset and affine mapping in the set up of $q$-normed space. First, we consider the closed subset and then weakly compact subsets for said purpose. Our results improve the
Nashine, Hemant Kumar
core +1 more source
Certain Banach spaces in connection with best approximation
Le Matematiche, 1998 See directly the article.
Antonio Martinón, F. Pérez-Acosta
doaj
Extensions of best approximation and coincidence theorems
International Journal of Mathematics and Mathematical Sciences, 1997 Let X be a Hausdorff compact space, E a topological vector space on which E* separates points, F:X→2E an upper semicontinuous multifunction with compact acyclic values, and g:X→E a continuous function such that g(X) is convex and g−1(y) is acyclic for ...
Sehie Park
doaj +1 more source