Results 61 to 70 of about 6,446,441 (278)

Genetic Dissection of Grain Size Traits Through Genome-Wide Association Study Based on Genic Markers in Rice

open access: yesRice Science, 2022
:: Grain size plays a significant role in rice, starting from affecting yield to consumer preference, which is the driving force for deep investigation and improvement of grain size characters. Quantitative inheritance makes these traits complex to breed
Amrit Kumar Nayak   +7 more
doaj   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

open access: yesAdvanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou   +6 more
wiley   +1 more source

Built-in Restrictions on Best Linear Unbiased Predictors (BLUP) of Random Effects in Mixed Models [PDF]

open access: yesThe American Statistician, 1997
Abstract In the usual mixed model of analysis of variance we show that certain sums of best linear unbiased predictors (BLUP) of random effects are zero. Those sums are similar to, but not exactly the same as, those of the Σ-restrictions sometimes used for fixed effects.
openaire   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

open access: yesAdvanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu   +7 more
wiley   +1 more source

Systems of mutually unbiased Hadamard matrices containing real and complex matrices [PDF]

open access: yes, 2013
We use combinatorial and Fourier analytic arguments to prove various non-existence results on systems of real and com- plex unbiased Hadamard matrices.
Matolcsi, Máté   +2 more
core   +1 more source

All-breed single-step genomic best linear unbiased predictor evaluations for fertility traits in US dairy cattle

open access: yesJournal of Dairy Science
: The US dairy cattle genetic evaluation is currently a multistep process, including multibreed traditional BLUP estimations followed by single-breed SNP effects estimation. Single-step GBLUP (ssGBLUP) combines pedigree and genomic data for all breeds in
J.M. Tabet   +7 more
doaj   +1 more source

The Fay–Herriot Model in Small Area Estimation

open access: yesRevstat Statistical Journal, 2020
Standard methods of variance component estimation used in the Fay-Herriot model for small areas can produce problems of inadmissible values (negative or zero) for these variances. This implies that the empirical best linear unbiased predictor of a small
José Luis Ávila-Valdez   +4 more
doaj   +1 more source

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

open access: yesAdvanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee   +11 more
wiley   +1 more source

Estimation of Simple Linear Regression Model Parameters Using Double Ranked Set Sampling [PDF]

open access: yesThe Egyptian Statistical Journal, 2002
The notion of ranked set sampling (RSS) for estimating the mean of a population and its advantage over the use of a simple random sampling for the same aim is well known and established in the literature. Furthermore, the double ranked set sampling (DRSS)
Elies Kouider
doaj   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

open access: yesAdvanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao   +8 more
wiley   +1 more source

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