Results 71 to 80 of about 6,446,441 (278)

Genomic Prediction of Manganese Efficiency in Winter Barley

The Plant Genome, 2016
Manganese efficiency is a quantitative abiotic stress trait controlled by several genes each with a small effect. Manganese deficiency leads to yield reduction in winter barley ( L.). Breeding new cultivars for this trait remains difficult because of the
Florian Leplat, Just Jensen, Per Madsen
doaj   +1 more source

Bias in Random Forest Variable Importance Measures: Illustrations, Sources and a Solution [PDF]

, 2006
Variable importance measures for random forests have been receiving increased attention as a means of variable selection in many classification tasks in bioinformatics and related scientific fields, for instance to select a subset of genetic markers ...
Zeileis, Achim, Carolin Strobl, Torsten Hothorn, Hothorn Torsten, Anne-Laure Boulesteix, Achim Zeileis, Boulesteix, Anne-Laure, Hothorn, Torsten, Boulesteix Anne-Laure, Zeileis Achim, Strobl Carolin, Strobl, Carolin   +11 more
core   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

A matrix approach to determine optimal predictors in a constrained linear mixed model

Open Mathematics
For a general vector of all unknown vectors in a constrained linear mixed model (CLMM), this study compared the dispersion matrices of the best linear unbiased predictors with any symmetric matrix for determining the optimality of predictors among others.
Güler Nesrin, Büyükkaya Melek Eriş
doaj   +1 more source

Small Area Estimation Using a Spatio-Temporal Linear Mixed Model

Revstat Statistical Journal, 2012
In this paper it is proposed a spatio-temporal area level linear mixed model involving spatially correlated and temporally autocorrelated random effects.
Luís N. Pereira , Pedro S. Coelho
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

Linear mixed models for series of variety trials [PDF]

, 2011
When using linear mixed models for analysis of series of variety trials, the statistical inference space is dependent on the design of the series. In this paper, four inference spaces are recognized for one-year crop variety trials: single-year local ...
Forkman, Johannes
core   +1 more source

MEAN SQUARED ERRORS OF SMALL AREA ESTIMATORS UNDER A UNIT-LEVEL MULTIVARIATE MODEL [PDF]

This work deals with estimating the vector of means of characteristics of small areas. In this context, a unit level multivariate model with correlated sampling errors is considered.
Isabel Molina, Amparo Baillo
core