Results 81 to 90 of about 6,446,441 (278)

A Real‐Data‐Driven Framework for Evaluating Differential Transcript Usage Methods Across Long‐Read Bulk, Single‐Cell, and Spatial Transcriptomics

Advanced Science, EarlyView.
Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang, Jun Liu, Qi Zhao, Huilong Yin, Angang Yang, Minhua Zheng, Rui Zhang   +6 more
wiley   +1 more source

Comparing Sampling and Estimation Strategies in Establishment Populations

Survey Research Methods, 2009
Population structure is a key determinant of the efficiency of sampling plans and estimators. Variables in many establishment populations have structures that can be described by simple linear models with a single auxiliary variable and a variance ...
Kimberly A Henry, Richard Valliant
doaj   +1 more source

Bayesian regularized quantile regression: A robust alternative for genome-based prediction of skewed data

Crop Journal, 2020
Genomic prediction (GP) has become a valuable tool for predicting the performance of selection candidates for the next breeding cycle. A vast majority of statistical linear models on which GP is based rely on the assumption of normality of the residuals ...
Paulino Pérez-Rodríguez, Osval A. Montesinos-López, Abelardo Montesinos-López, José Crossa   +3 more
doaj   +1 more source

Technical note: Prediction of liveweight from linear conformation traits in dairy cattle [PDF]

, 2012
The objectives of this study were to derive phenotypic and genetic prediction equations of liveweight from linear conformation traits, and estimate genetic and phenotypic parameters for these traits.
Coffey, M. P., Coffey, MP, Banos, G., Banos, G; id_orcid   +3 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Genomic evaluation of Holstein cattle in Antioquia (Colombia): a case study

Revista Colombiana de Ciencias Pecuarias, 2014
Background: DNA markers have been widely used in genetic evaluation throughout the last decade due to the increased reliability of breeding values (BV) they allow, mainly in young animals.
Julián Echeverri, Juan C Zambrano, Albeiro López Herrera   +2 more
doaj  

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Best linear unbiased prediction for linear combinations in general mixed linear models [PDF]

, 2008
The general mixed linear model can be written as y=Xβ+Zu+e. In this paper, we mainly deal with two problems. Firstly, the problem of predicting a general linear combination of fixed effects and realized values of random effects in a general mixed linear ...
Liu, Xiu-Ying, Liu, Xu-Qing, Rong, Jian-Ying   +2 more
core   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

Perspective: Quantum Computing on Magnetic Racetrack

Advanced Electronic Materials, EarlyView.
Magnetic domain walls emerge as mobile qubits on quantum racetracks, where chirality encodes quantum information and current‐driven motion enables flying‐qubit functionality. This Perspective outlines the physical principles, gate mechanisms, material requirements, and experimental roadmap for realizing scalable quantum computing with magnetic textures,
Ji Zou, Jelena Klinovaja, Daniel Loss
wiley   +1 more source