Results 31 to 40 of about 14,265,519 (265)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
An Improved Version of the Parameterized Hardy–Hilbert Inequality Involving Two Partial Sums
MathematicsIn this paper, by employing the Euler–Maclaurin summation formula and real analysis techniques, an improved version of the parameterized Hardy–Hilbert inequality involving two partial sums is established.
Bicheng Yang, Shanhe Wu
doaj +1 more source
On a new discrete Mulholland-type inequality in the whole plane
Journal of Inequalities and Applications, 2018 A new discrete Mulholland-type inequality in the whole plane with a best possible constant factor is presented by introducing multi-parameters, applying weight coefficients, and using Hermite–Hadamard’s inequality.
Bicheng Yang, Qiang Chen
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Finding best possible constant for a polynomial inequality [PDF]
, 2020 Given a multi-variant polynomial inequality with a parameter, how to find the best possible value of this parameter that satisfies the inequality? For instance, find the greatest number k that satisfies a 3 +b 3 +c 3 +k(a 2 b+b 2 c+c 2 a)−(k+1)(ab 2 +bc ...
Lu Yang, Ju Zhang
core
A more accurate Mulholland-type inequality in the whole plane
Journal of Inequalities and Applications, 2017 By introducing independent parameters, applying the weight coefficients, and Hermite-Hadamard’s inequality, we give a more accurate Mulholland-type inequality in the whole plane with a best possible constant factor. Furthermore, the equivalent forms, the
Yanru Zhong, Bicheng Yang, Qiang Chen
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
MathematicsIn this paper, by using the techniques of real analysis, with the help of the Euler–Maclaurin summation formula, Abel’s summation by parts formula, and the differentiation mid-value theorem, we establish a half-discrete Hardy–Mulholland-type inequality ...
Bicheng Yang, Shanhe Wu, Jianquan Liao
doaj +1 more source
On a New Extension of Mulholland’s Inequality in the Whole Plane
Journal of Function Spaces, 2018 A new, more accurate extension of Mulholland’s inequality in the whole plane with a best possible constant factor is presented by introducing independent parameters, applying weight coefficients and using Hermite-Hadamard’s inequality.
Bicheng Yang, Yanru Zhong, Qiang Chen
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source