Results 41 to 50 of about 380,648 (224)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

On a New Half-Discrete Hilbert-Type Inequality Involving the Variable Upper Limit Integral and Partial Sums

Mathematics, 2020
In this paper we establish a new half-discrete Hilbert-type inequality involving the variable upper limit integral and partial sums. As applications, an inequality obtained from the special case of the half-discrete Hilbert-type inequality is further ...
Jianquan Liao, Shanhe Wu, Bicheng Yang
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On a more accurate Hardy-Mulholland-type inequality

Journal of Inequalities and Applications, 2016
By using weight coefficients, technique of real analysis, and Hermite-Hadamard’s inequality, we give a more accurate Hardy-Mulholland-type inequality with multiparameters and a best possible constant factor related to the beta function.
Bicheng Yang, Qiang Chen
doaj   +1 more source

On a New Extended Hardy–Hilbert’s Inequality with Parameters

Mathematics, 2020
In this paper, by introducing parameters and weight functions, with the help of the Euler−Maclaurin summation formula, we establish the extension of Hardy−Hilbert’s inequality and its equivalent forms.
Bicheng Yang, Shanhe Wu, Jianquan Liao
doaj   +1 more source

On a reverse Mulholland-type inequality in the whole plane with general homogeneous kernel

Journal of Inequalities and Applications, 2021
By using the idea of introducing parameters and weight coefficients, a new reverse discrete Mulholland-type inequality in the whole plane with general homogeneous kernel is given, which is an extension of the reverse Mulholland inequality. The equivalent
Ricai Luo, Bicheng Yang, Xingshou Huang
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

On a more accurate reverse Mulholland-type inequality with parameters

Journal of Inequalities and Applications, 2019
By the use of the weight coefficients, the idea of introducing parameters and Hermite–Hadamard’s inequality, a more accurate reverse Mulholland-type inequality with parameters and the equivalent forms are given.
Leping He, Hongyan Liu, Bicheng Yang
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source