Results 41 to 50 of about 2,708,851 (245)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

A Half-Discrete Hardy–Mulholland-Type Inequality Involving One Multiple Upper Limit Function and One Partial Sum

Mathematics
In this paper, by using the techniques of real analysis, with the help of the Euler–Maclaurin summation formula, Abel’s summation by parts formula, and the differentiation mid-value theorem, we establish a half-discrete Hardy–Mulholland-type inequality ...
Bicheng Yang, Shanhe Wu, Jianquan Liao
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A New Hardy–Hilbert-Type Integral Inequality Involving General Homogeneous Kernel and Two Derivative Functions of Higher Order

Mathematics
In this paper, by introducing a general homogeneous kernel function and several parameters, we establish a new Hardy–Hilbert-type integral inequality involving two derivative functions of higher-order.
Bicheng Yang, Shanhe Wu, Xianyong Huang
doaj   +1 more source

A New Extension of Hardy-Hilbert’s Inequality in the Whole Plane

Journal of Function Spaces, 2016
By the use of weight coefficients and Hermite-Hadamard’s inequality, a new extension of Hardy-Hilbert’s inequality in the whole plane with multiparameters and a best possible constant factor is given. The equivalent forms, the operator expressions, and a
Bicheng Yang, Qiang Chen
doaj   +1 more source

On a more accurate Hardy-Mulholland-type inequality

Journal of Inequalities and Applications, 2017
By using the way of weight coefficients, the technique of real analysis, and Hermite-Hadamard’s inequality, a more accurate Hardy-Mulholland-type inequality with multi-parameters and a best possible constant factor is given.
Bicheng Yang, Qiang Chen
doaj   +1 more source

Adaptive Bound Optimization for Online Convex Optimization [PDF]

, 2010
We introduce a new online convex optimization algorithm that adaptively chooses its regularization function based on the loss functions observed so far.
McMahan, H. Brendan, Streeter, Matthew
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

On a New Extension of Mulholland’s Inequality in the Whole Plane

Journal of Function Spaces, 2018
A new, more accurate extension of Mulholland’s inequality in the whole plane with a best possible constant factor is presented by introducing independent parameters, applying weight coefficients and using Hermite-Hadamard’s inequality.
Bicheng Yang, Yanru Zhong, Qiang Chen
doaj   +1 more source