Results 61 to 70 of about 14,265,519 (265)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
A Half-Discrete Hilbert-Type Inequality in the Whole Plane with Multiparameters
Journal of Function Spaces, 2016 By the use of weight functions and technique of real analysis, a new half-discrete Hilbert-type inequality in the whole plane with multiparameters and the best possible constant factor is given.
Qunwei Ma, Bicheng Yang, Leping He
doaj +1 more source
A more accurate half-discrete Hardy-Hilbert-type inequality with the logarithmic function
Journal of Inequalities and Applications, 2017 By means of the weight functions, the technique of real analysis and Hermite-Hadamard’s inequality, a more accurate half-discrete Hardy-Hilbert-type inequality related to the kernel of logarithmic function and a best possible constant factor is given ...
Aizhen Wang, Bicheng Yang
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
An extension of a multidimensional Hilbert-type inequality
Journal of Inequalities and Applications, 2017 In this paper, by the use of weight coefficients, the transfer formula and the technique of real analysis, a new multidimensional Hilbert-type inequality with multi-parameters and a best possible constant factor is given, which is an extension of some ...
Jianhua Zhong, Bicheng Yang
doaj +1 more source
On a multiple Hilbert-type integral inequality involving the upper limit functions
Journal of Inequalities and Applications, 2021 By applying the weight functions, the idea of introducing parameters and the technique of real analysis, a new multiple Hilbert-type integral inequality involving the upper limit functions is given.
Jianhua Zhong, Bicheng Yang
doaj +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Parameterized discrete Hilbert-type inequalities with intermediate variables
Journal of Inequalities and Applications, 2019 By means of the weight coefficients and the idea of introducing parameters, a discrete Hilbert-type inequality with the general homogeneous kernel and the intermediate variables is given. The equivalent form is obtained.
Ricai Luo, Bicheng Yang
doaj +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Toward the best constant factor for the Rademacher-gaussian tail comparison [PDF]
, 2007 It is proved that the best constant factor in the Rademacher-Gaussian tail comparison is between two explicitly defined absolute constants c1 and c2 such that c2≈1.01 c1.
Pinelis, Iosif, Iosif Pinelis
core +1 more source