Results 51 to 60 of about 1,095,660 (289)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Existence of fixed point and best proximity point of p-cyclic orbital phi-contraction map

Nonlinear Analysis, 2022
In this manuscript, p-cyclic orbital ϕ-contraction map over closed, nonempty, convex subsets of a uniformly convex Banach space X possesses a unique best proximity point if the auxiliary function ϕ is strictly increasing.
Prabavathy Magadevan, Saravanan Karpagam, Erdal Karapınar   +2 more
doaj   +1 more source

Evolution of the Ionizing Background at High Redshifts [PDF]

, 1996
We use a Maximum-Likelihood analysis to constrain the value and evolution of the ionizing background for ...
Carswell, Bob, Cooke, Andrew, Espey, Brian   +2 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Best proximity points in ℱ-metric spaces with applications

Demonstratio Mathematica, 2023
The aim of this article is to introduce α\alpha -ψ\psi -proximal contraction in the setting of ℱ-metric space and prove the existence of best proximity points for these contractions.
Lateef Durdana
doaj   +1 more source

On the Proximity Factors of Lattice Reduction-Aided Decoding [PDF]

, 2010
Lattice reduction-aided decoding features reduced decoding complexity and near-optimum performance in multi-input multi-output communications. In this paper, a quantitative analysis of lattice reduction-aided decoding is presented.
Ling, Cong
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Existence of coupled coincidence best proximity point [PDF]

Surveys in Mathematics and its Applications
This work of optimality is engaged with couple coincidence best proximity point. We have developed some optimal results where control functions and non-linear weak inequalities are evident. Further using our results, we establish some fixed point results.
Pulak Konar, Sumit Chandok
doaj