Results 111 to 120 of about 743,371 (240)

Design and synthesis of small molecule BET inhibitors [PDF]

The confidentiality statement on each page of this thesis DOES NOT apply.Previously held under moratorium in Chemistry department (GSK) from 11/3/2020 until 20/03/2025.Small molecule Bromodomain and Extra-Terminal (BET) inhibitors have shown promising ...
Kessedjian, Hripsimée
core   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition. [PDF]

Mil Med Res, 2023
Meng Y, Sun HY, He Y, Zhou Q, Liu YH, Su H, Yin MZ, Zeng FR, Chen X, Deng GT.   +9 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Recent progress and structural analyses of domain-selective BET inhibitors. [PDF]

Med Res Rev, 2023
Divakaran A, Harki DA, Pomerantz WCK.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors. [PDF]

Int J Mol Sci, 2023
Elshazly AM, Gewirtz DA.
europepmc   +1 more source

BET isoform selectivity through diverse linkers for bivalent inhibitors : GSK785, a BRD2/4-selective bivalent BET inhibitor [PDF]

The inhibition of the Bromodomain and Extra Terminal (BET) family of proteins has been widely studied for over a decade for its potential therapeutic benefit in cancer and immuno-inflammatory diseases.
Grandi, Paola, Bamborough, Paul, Phillipou, Alex, Demont, Emmanuel H., Atkinson, Stephen J., Prinjha, Rab K., Neipp, Christopher E, Preston, Alex G. S., Friston, Kallie, Tomkinson, Nicholas C. O., Petretich, Massimo, Barnett, Heather A, Rianjongdee, Francesco   +12 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Current landscape of BRD4 inhibitors: Selective targeting and protein degradation for enhanced efficacy

Results in Chemistry
The bromodomain and extra-terminal domain (BET) family of proteins has been implicated as a crucial factor in the pathogenesis of numerous diseases by regulating gene expression and chromatin dynamics through its bromodomains, which bind to acetylated ...
Linlin Deng, Erkang Tian, Ting Ma, Shaojie Liang, Sijia Hu, Linwei Li, Juan Li   +6 more
doaj   +1 more source