Results 121 to 130 of about 743,371 (240)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Design and synthesis of dimethylisoxazole quinolines as BET inhibitors [PDF]
Previously held under moratorium in Chemistry department (GSK) from 1/6/15 until 3 September 2021.The confidentiality statement on each page of this thesis DOES NOT applyGene regulation is governed by the assembly of protein complexes capable of reading ...
Wellaway, Christopher Roland
core +2 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression. [PDF]
Exp Mol Med, 2023 Zeng F +7 more
europepmc +1 more source
Systematically Mitigating the p38α Activity of Triazole-based BET Inhibitors
, 2019 The Bromodomain and Extra Terminal (BET) family of proteins recognize post-translational N-ε-acetylated lysine modifications, regulating transcription as “reader” proteins.
William C. K. Pomerantz (1476328) +13 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells. [PDF]
J Enzyme Inhib Med Chem, 2023 Negri A +5 more
europepmc +1 more source
Bet-hedging region in temporally varying environments.
, 2019 Optimal strategy α* as a function of growth rates and for range expansions in temporally varying environments under the limits of environmental change rate (A) k → 0, see Eq (7), and (B) k → ∞. In all panels, lines delimit the bet-hedging region 0 ≤ α*
Simone Pigolotti (160209) +2 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source