Results 31 to 40 of about 24,956 (275)
, 2023 Additional file 1: Methods for BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition. Fig. S1 BET inhibitors synergize with GPX4 inhibition in melanoma cells. Fig.
Ming-Zhu Yin (10350290) +9 more
core +1 more source
Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma
EMBO Molecular Medicine, 2019 Alterations in transcriptional programs promote tumor development and progression and are targetable by bromodomain and extraterminal (BET) protein inhibitors.
Vivian Chua +12 more
doaj +1 more source
PLoS ONE, 2023 The decidua undergoes proinflammatory activation in late pregnancy, promoting labor. Bromodomain and Extra-Terminal (BET) family proteins interact with acetylated histones and may control gene expression in inflammation.
Sandeep Ajgaonkar +3 more
doaj +1 more source
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 [PDF]
, 2017 The bromodomain and extra-terminal (BET) family of proteins, comprised of four members including BRD2, BRD3, BRD4 and the testis-specific isoform BRDT, largely function as transcriptional co-activators 1–3 and play critical roles in various cellular ...
Andrew H Beck +71 more
core +2 more sources
Frontiers in Oncology, 2022 BackgroundColorectal cancer (CRC) frequently has a dysregulated epigenome causing aberrant up-regulation of oncogenes such as c-MYC. Bromodomain and extra-terminal domain (BET) proteins and histone acetyltransferases (HAT) are epigenetic regulatory ...
Chaoyuan Kuang +18 more
doaj +1 more source
Systematically Mitigating the p38α Activity of Triazole-based BET Inhibitors. [PDF]
ACS Med Chem Lett, 2019 The Bromodomain and Extra Terminal (BET) family of proteins recognize post-translational N-ε-acetylated lysine modifications, regulating transcription as “reader” proteins.
Carlson AS +6 more
europepmc +2 more sources
BET inhibitors: a novel epigenetic approach
Annals of Oncology, 2017 Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states.' Currently, several classes of anticancer drugs function at the epigenetic level, including inhibitors of DNA methyltransferase, histone deacetylase (HDAC), lysine-specific demethylase 1, zeste homolog 2 ...
D B, Doroshow, J P, Eder, P M, LoRusso
openaire +2 more sources
Vitamin C Sensitizes Melanoma to BET Inhibitors [PDF]
Cancer Research, 2018 Abstract Bromodomain and extraterminal inhibitors (BETi) are promising cancer therapies, yet prominent side effects of BETi at effective doses have been reported in phase I clinical trials. Here, we screened a panel of small molecules targeting epigenetic modulators against human metastatic melanoma cells.
Sushmita, Mustafi +8 more
openaire +2 more sources
BET inhibitor suppresses migration of human hepatocellular carcinoma by inhibiting SMARCA4
Scientific Reports, 2021 Hepatocellular carcinoma (HCC) is one of the most prevalent and poorly responsive cancers worldwide. Bromodomain and extraterminal (BET) inhibitors, such as JQ1 and OTX-015, inhibit BET protein binding to acetylated residues in histones.
Hae In Choi +7 more
doaj +1 more source
BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency.
, 2017 Kaposi's Sarcoma-associated Herpesvirus (KSHV) establishes stable latent infection in B-lymphocytes and pleural effusion lymphomas (PELs). During latency, the viral genome persists as an epigenetically constrained episome with restricted gene expression ...
Alessandra De Leo +11 more
core +1 more source