Epigenetics and chromatin remodeling play a role in lung disease [PDF]
, 2011 Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA ...
Adcock, IM +3 more
core +1 more source
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer [PDF]
, 2013 PurposeAmplification of MYC is one of the most common genetic alterations in lung cancer, contributing to a myriad of phenotypes associated with growth, invasion and drug resistance.
Akbay, Esra +14 more
core +1 more source
Bromodomain Inhibitors as Therapeutics for Herpesvirus-Related Disease: All BETs Are Off?
Frontiers in Cellular and Infection Microbiology, 2020 Although the ubiquitous human herpesviruses (HHVs) are rarely associated with serious disease of the healthy host, primary infection and reactivation in immunocompromised individuals can lead to significant morbidity and, in some cases, mortality ...
Ian J. Groves +2 more
doaj +1 more source
Cell Reports, 2014 BET family proteins are novel therapeutic targets for cancer and inflammation and represent the first chromatin readers against which small-molecule inhibitors have been developed.
Jessica E. Bolden +7 more
doaj +1 more source
BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
Cell Reports, 2016 Restoration of anti-tumor immunity by blocking PD-L1 signaling through the use of antibodies has proven to be beneficial in cancer therapy. Here, we show that BET bromodomain inhibition suppresses PD-L1 expression and limits tumor progression in ovarian ...
Hengrui Zhu +10 more
doaj +1 more source
Bromodomain and extra-terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension [PDF]
, 2016 Background and objective Nuclear factor kappa B (NF-kB)-mediated inflammatory gene expression and vascular endothelial cell proliferation/remodelling are implicated in the pathophysiology of the fatal disease, pulmonary arterial hypertension (PAH ...
Adcock, IM +6 more
core +1 more source
Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome [PDF]
, 2017 Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies.
Cannoodt, Robrecht +6 more
core +3 more sources
PLoS ONE, 2013 BET family proteins are epigenetic regulators known to control expression of genes involved in cell growth and oncogenesis. Selective inhibitors of BET proteins exhibit potent anti-proliferative activity in a number of hematologic cancer models, in part ...
Anastasia Wyce +18 more
doaj +1 more source
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma
Cell & BioscienceBackground B-cell non-Hodgkin lymphoma (B-NHL) is the most common type of lymphoma and is significantly heterogeneous among various subtypes. Despite of considerable advancements in treatment strategies for B-NHL, the prognosis of relapsed/refractory ...
Dan Zou +7 more
doaj +1 more source
Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]
, 2019 Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi +3 more
core +2 more sources