Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. [PDF]
Circulation Research, 1994 The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this desensitization may in part be caused by an increase in beta-adrenergic receptor kinase (beta ARK) expression.
Martin Ungerer +6 more
semanticscholar +7 more sources
Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. [PDF]
Proceedings of the National Academy of Sciences, 1991 Three separate processes may contribute to rapid beta-adrenergic receptor desensitization: functional uncoupling from the stimulatory guanine nucleotide-binding protein Gs, mediated by phosphorylation of the receptors by two distinct kinases, the ...
Neil S. Roth +4 more
semanticscholar +5 more sources
A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. [PDF]
Proceedings of the National Academy of Sciences, 1993 We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document that subtype 2 of the beta-
Sabine Schleicher +4 more
semanticscholar +5 more sources
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C. [PDF]
Proceedings of the National Academy of Sciences, 1996 The beta-adrenergic receptor kinase (betaARK) is the prototypical member of the family of cytosolic kinases that phosphorylate guanine nucleotide binding-protein-coupled receptors and thereby trigger uncoupling between receptors and guanine nucleotide ...
Rainer Winstel +4 more
semanticscholar +6 more sources
Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2. [PDF]
Journal of Clinical Investigation, 1995 Beta-adrenergic receptor kinase (beta ARK) is a serine-threonine kinase involved in the process of homologous desensitization of G-coupled receptors.
Antonio De Blasi +2 more
semanticscholar +5 more sources
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. [PDF]
Proceedings of the National Academy of Sciences, 1991 Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RK) and beta-adrenergic receptor ...
W Lorenz +5 more
semanticscholar +4 more sources
Circulation Journal, 2005 BACKGROUND Enhanced expression of G protein-coupled receptor kinase (GRK) has been reported in failing hearts and in the present study the stability of enhanced GRK mRNA expression, and the correlation between the expression level of GRK mRNA in ...
Naotsugu Oyama +8 more
openalex +3 more sources
Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1994 The roles of three protein kinases, cyclic AMP-dependent protein kinase (protein kinase A), protein kinase C, and beta-adrenergic receptor kinase (beta ARK), implicated in agonist-induced desensitization of guanine nucleotide-binding protein (G-protein ...
Meng-Fu Maxwell Shih, C C Malbon
openalex +2 more sources
Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]
Research Results in Pharmacology, 2022 Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki +10 more
doaj +3 more sources