Results 1 to 10 of about 10,757 (121)

Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
doaj   +3 more sources

ADAM17, A Key Player of Cardiac Inflammation and Fibrosis in Heart Failure Development During Chronic Catecholamine Stress

Frontiers in Cell and Developmental Biology, 2021
Heart failure development is characterized by persistent inflammation and progressive fibrosis owing to chronic catecholamine stress. In a chronic stress state, elevated catecholamines result in the overstimulation of beta-adrenergic receptors (βARs ...
Joseph Adu-Amankwaah, Gabriel Komla Adzika, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Richard Mprah, Aisha Bushi, Nazma Akhter, Fei Huang, Yaxin Xu, Seyram Yao Adzraku, Iqra Nadeem, Hong Sun   +11 more
doaj   +1 more source

Activation of the Thiazide-Sensitive Sodium-Chloride Cotransporter by Beta3-Adrenoreceptor in the Distal Convoluted Tubule

Frontiers in Physiology, 2021
We previously showed that the beta-3 adrenergic receptor (BAR3) is expressed in most segments of the nephron where its agonism promotes a potent antidiuretic effect.
Serena Milano, Monica Carmosino, Andrea Gerbino, Ilenia Saponara, Dominga Lapi, Massimo Dal Monte, Paola Bagnoli, Maria Svelto, Giuseppe Procino   +8 more
doaj   +1 more source

Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. [PDF]

Proceedings of the National Academy of Sciences, 1991
Three separate processes may contribute to rapid beta-adrenergic receptor desensitization: functional uncoupling from the stimulatory guanine nucleotide-binding protein Gs, mediated by phosphorylation of the receptors by two distinct kinases, the specific beta-adrenergic receptor kinase (beta ARK) and the cyclic AMP-dependent protein kinase A (PKA), as
N S, Roth, P T, Campbell, M G, Caron, R J, Lefkowitz, M J, Lohse   +4 more
openaire   +2 more sources

Rapid desensitization of neonatal rat liver beta-adrenergic receptors. A role for beta-adrenergic receptor kinase. [PDF]

Journal of Clinical Investigation, 1994
Exposure of beta-adrenergic receptors (BAR) to agonists often leads to a rapid loss of receptor responsiveness. The proposed mechanisms of such rapid receptor desensitization include receptor phosphorylation by either cAMP-dependent protein kinase or the specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl ...
I, García-Higuera, F, Mayor
openaire   +2 more sources

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. [PDF]

Proceedings of the National Academy of Sciences, 1991
Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RK) and beta-adrenergic receptor kinase (beta ARK), respectively. We report here the cloning of a complementary DNA for RK.
Lorenz, W, Inglese, J, Palczewski, K, Onorato, JJ, Caron, MG, Lefkowitz, RJ   +5 more
openaire   +2 more sources

Mechanism of beta-adrenergic receptor kinase activation by G proteins

Journal of Biological Chemistry, 1993
The beta-adrenergic receptor kinase (beta-ARK) specifically phosphorylates the activated form of various G protein-coupled receptors such as the beta 2-adrenergic receptor (beta 2-AR). Recently, G protein beta gamma subunits have been demonstrated to activate beta-ARK-mediated receptor phosphorylation.
C M, Kim, S B, Dion, J L, Benovic
openaire   +4 more sources

Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. [PDF]

Journal of Clinical Investigation, 1995
To determine whether beta-adrenergic receptor agonist activation influences guanosine 5'-triphosphate-binding protein (G-protein) expression and beta-adrenergic receptor kinase activity in the heart, we examined the effects of chronic beta 1-adrenergic receptor antagonist treatment (bisoprolol, 0.2 mg/kg per d i.v., 35 d) on components of the ...
P, Ping, R, Gelzer-Bell, D A, Roth, D, Kiel, P A, Insel, H K, Hammond   +5 more
openaire   +2 more sources

β-Adrenergic Receptor Kinase (GRK2) Colocalizes with β-Adrenergic Receptors during Agonist-induced Receptor Internalization [PDF]

Journal of Biological Chemistry, 1997
Rapid regulation of G protein-coupled receptors appears to involve agonist-promoted receptor phosphorylation by G protein-coupled receptor kinases (GRKs). This is followed by binding of uncoupling proteins termed arrestins and transient receptor internalization. In this report we show that the beta-adrenergic receptor kinase (betaARK-1 or GRK2) follows
A, Ruiz-Gómez, F, Mayor
openaire   +4 more sources

Inhibition of the beta-adrenergic receptor kinase by polyanions.

The Journal of biological chemistry, 1989
The beta-adrenergic receptor kinase, which specifically phosphorylates the agonist-occupied beta-adrenergic receptor, is strongly inhibited by polyanions. Heparin and dextran sulfate inhibit the enzyme with an IC50 of approximately 0.15 microM. De-N-sulfated heparin is approximately 8-fold less potent.
J L, Benovic, W C, Stone, M G, Caron, R J, Lefkowitz   +3 more
openaire   +2 more sources