Results 1 to 10 of about 2,011,206 (240)

Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
doaj   +3 more sources

ADAM17, A Key Player of Cardiac Inflammation and Fibrosis in Heart Failure Development During Chronic Catecholamine Stress

Frontiers in Cell and Developmental Biology, 2021
Heart failure development is characterized by persistent inflammation and progressive fibrosis owing to chronic catecholamine stress. In a chronic stress state, elevated catecholamines result in the overstimulation of beta-adrenergic receptors (βARs ...
Joseph Adu-Amankwaah, Gabriel Komla Adzika, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Richard Mprah, Aisha Bushi, Nazma Akhter, Fei Huang, Yaxin Xu, Seyram Yao Adzraku, Iqra Nadeem, Hong Sun   +11 more
doaj   +1 more source

Activation of the Thiazide-Sensitive Sodium-Chloride Cotransporter by Beta3-Adrenoreceptor in the Distal Convoluted Tubule

Frontiers in Physiology, 2021
We previously showed that the beta-3 adrenergic receptor (BAR3) is expressed in most segments of the nephron where its agonism promotes a potent antidiuretic effect.
Serena Milano, Monica Carmosino, Andrea Gerbino, Ilenia Saponara, Dominga Lapi, Massimo Dal Monte, Paola Bagnoli, Maria Svelto, Giuseppe Procino   +8 more
doaj   +1 more source

ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Tozzi M, Berggreen EB, Zhang R, Gudiksen A, Li W, Matz MB, Pilegaard H, Hansen JB, Novak I.   +8 more
europepmc   +2 more sources

Targeting β-Adrenergic Signaling in Colorectal Cancer: Molecular Mechanisms and Therapeutic Potential of β-Blockers. [PDF]

Cancers (Basel)
Rogacz Z, Pacuła WW, Janas W, Markiewka M, Wala P, Madej M, Strzałka-Mrozik B.   +6 more
europepmc   +1 more source

<i>α</i> _1A-Adrenergic receptor (<i>ADRA1A</i>) signaling signatures as prognostic biomarkers in liver hepatocellular carcinoma: a bioinformatic analysis. [PDF]

In Silico Pharmacol
Beltrán-Navarro YM, Vázquez-Prado J, Reyes-Cruz G, García-Sáinz JA.   +3 more
europepmc   +1 more source

Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology. [PDF]

Kinases Phosphatases
Dotson CR, Underwood L, Sato PY.
europepmc   +1 more source

Effect of the gut microbiota metabolite phenylacetylglycine on cardiac Ca²⁺ signaling. [PDF]

Biophys Rep (N Y)
Bovo E, Zima AV.
europepmc   +1 more source

P2X7-NEK7-NLRP3 Axis Drives Cardiac Inflammation and Fibrosis in Isoproterenol-Induced Cardiac Remodeling in Mice. [PDF]

Acta Physiol (Oxf)
Parletta AC, Cerri GC, Fevereiro M, Panico K, Gasparini CRB, Vieira-Junior DN, de Almeida Silva A, Senger N, Diniz GP, Castelucci P, Irigoyen MCC, Barreto-Chaves MLM.   +11 more
europepmc   +1 more source

Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart. [PDF]

J Physiol
Diba P, Levasseur PR, Newton SD, Koh KMS, Arneson-Wissink PC, Zhu X, Pham P, Mendez H, Whitcomb L, Sattler A, Woodward WR, Habecker BA, Marks DL, Grossberg AJ.   +13 more
europepmc   +1 more source