Rapid desensitization of neonatal rat liver beta-adrenergic receptors. A role for beta-adrenergic receptor kinase. [PDF]
Journal of Clinical Investigation, 1994 Exposure of beta-adrenergic receptors (BAR) to agonists often leads to a rapid loss of receptor responsiveness. The proposed mechanisms of such rapid receptor desensitization include receptor phosphorylation by either cAMP-dependent protein kinase or the specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl ...
Irene García-Higuera, Federico Mayor
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A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. [PDF]
Proceedings of the National Academy of Sciences, 1993 We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document that subtype 2 of the beta-adrenergic receptor kinase (beta ARK) is also involved in this process.
Sabine Schleicher +4 more
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Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]
Research Results in Pharmacology, 2022 Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki +10 more
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Frontiers in Cell and Developmental Biology, 2021 Heart failure development is characterized by persistent inflammation and progressive fibrosis owing to chronic catecholamine stress. In a chronic stress state, elevated catecholamines result in the overstimulation of beta-adrenergic receptors (βARs ...
Joseph Adu-Amankwaah +11 more
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Frontiers in Physiology, 2021 We previously showed that the beta-3 adrenergic receptor (BAR3) is expressed in most segments of the nephron where its agonism promotes a potent antidiuretic effect.
Serena Milano +8 more
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Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling [PDF]
, 2022 Bénédicte Rousseau +3 more
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B014 Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac $beta;-adrenergic receptors [PDF]
, 1998 Minghui Zhang
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Oligomerization of opioid receptors with beta 2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation [PDF]
, 2000 Bryen A. Jordan +4 more
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