Results 41 to 50 of about 61,745 (283)

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]

, 2015
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam, Chang, Louise, Downes, Michael, Evans, Ronald M, Korytnaya, Evgenia, Krause, Danielle M, Liddle, Christopher, Lumeng, Carey N, Neidert, Adam, Oral, Elif A, Peng, Xiaoling, Poirier, BreAnne, Reilly, Shannon M, Saltiel, Alan R, Uhm, Maeran, Yu, Ruth T, Zamarron, Brian F   +16 more
core   +2 more sources

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

Journal of Biological Chemistry, 1993
Studies of the human m2 (hm2) muscarinic cholinergic receptors (mAChR) have been performed to provide further insights into the potential regulation of these receptors by isoforms of the beta-adrenergic receptor kinase (beta ARK). The hm2 mAChR and the isoforms beta ARK1 and beta ARK2 were individually expressed in, and purified from, insect Sf9 cells ...
Ricardo M. Richardson, C. Kim, Jeffrey Benovic, Marie Thérèse Hosey   +3 more
openalex   +4 more sources

Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.

Journal of Biological Chemistry, 1987
The beta-adrenergic receptor kinase is a cytosolic enzyme that specifically phosphorylates the agonist-occupied form of the beta-adrenergic receptor (beta AR). Beta AR kinase appears to be translocated from the cytosol to the plasma membrane when kin- S49 lymphoma cells are incubated with either beta-adrenergic agonists or prostaglandin E1, both of ...
Federico Mayor, Jeffrey Benovic, M G Caron, R J Lefkowitz   +3 more
openalex   +3 more sources

Inhibition of the β-Adrenergic Receptor Kinase by Polyanions

Journal of Biological Chemistry, 1989
The beta-adrenergic receptor kinase, which specifically phosphorylates the agonist-occupied beta-adrenergic receptor, is strongly inhibited by polyanions. Heparin and dextran sulfate inhibit the enzyme with an IC50 of approximately 0.15 microM. De-N-sulfated heparin is approximately 8-fold less potent.
Robert J. Lefkowitz, Marc G. Caron, Jeffrey L. Benovic, W.C. Stone   +3 more
openaire   +3 more sources

Considering the role of Murine double minute 2 in the cardiovascular system [PDF]

, 2019
The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53 ...
Lam, Brian, Roudier, Emile
core   +1 more source

The β-Adrenergic Receptor Is a Substrate for the Insulin Receptor Tyrosine Kinase [PDF]

Journal of Biological Chemistry, 1996
G-protein-linked receptors and intrinsic tyrosine-kinase growth receptors represent two prominent modalities in cell signaling. Cross-regulation among members of both receptor superfamilies has been reported, including the counter-regulatory effects of insulin on beta-adrenergic catecholamine action.
Baltensperger, Kurt, Karoor, Vijaya, Paul, Hyacinth, Ruoho, Arnold E., Czech, Michael P., Malbon, Craig C.   +5 more
openaire   +4 more sources

Critical Roles of STAT3 in β-Adrenergic Functions in the Heart [PDF]

, 2016
BACKGROUND: β-Adrenergic receptors (βARs) play paradoxical roles in the heart. On one hand, βARs augment cardiac performance to fulfill the physiological demands, but on the other hand, prolonged activations of βARs exert deleterious effects that ...
Chen, Biyi, Chen, Hanying, Fu, Xin-Yuan, Huang, Xin-Yun, Li, Baiyan, Li, Deqiang, Li, Xie, Liu, Ying, Qu, Xiuxia, Rubart, Michael, Shou, Weinian, Snyder, Marylynn, Song, Long-Sheng, Tang, Yue, Wang, Meijing, Yin, Ni, Zhan, Li, Zhang, J. Jillian, Zhang, Wenjun, Zhu, Wuqiang   +19 more
core   +1 more source

Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors [PDF]

, 2010
The regulatory function of α1B-adrenoceptors in mammalian heart homeostasis is controversial. The objective of the present study was to characterize the expression/activity of key proteins implicated in cardiac calcium handling (Na+/K+-ATPase and Ca2 ...
Barreto, Frederico, Caricati-Neto, Afonso, Cunha, Valeria do Monti Nascimento, Jurkiewicz, Aron, Noël, Francois, Quintas, Luis Eduardo Menezes, Rezende, Daniele Campos, Scaramello, Christianne Bretas Vieira, Silva, Claudia Lucia Martins   +8 more
core   +2 more sources

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

Journal of Biological Chemistry, 1993
The agonist-occupied forms of several G-protein-coupled receptors that modulate the activity of adenylycyclase via Gs (e.g. beta 2-adrenergic) or Gi (e.g. alpha 2-adrenergic and cardiac muscarinic) are phosphorylated by beta-adrenergic receptor kinases (beta ARK 1 and beta ARK 2).
Madan M. Kwatra, Debra A. Schwinn, Jolanda Schreurs, Jonathan L. Blank, C.M. Kim, Jeffrey Benovic, James E. Krause, Marc G. Caron, Robert J. Lefkowitz   +8 more
openalex   +4 more sources

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]

, 2015
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina, Beltran-Alvarez, Pedro, Berne, Paola, Bosch Calero, Cristina, Brugada, Josep, Brugada, Ramon, Campuzano, Oscar, Iglesias, Anna, Pérez, Carmelo, Pérez, Guillermo J., Ruiz Hernandez, Pablo M., Scornik, Fabiana S., Wangüemert, Fernando   +12 more
core   +2 more sources