Results 41 to 50 of about 8,484 (124)

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. [PDF]

Proceedings of the National Academy of Sciences, 1989
Homologous (agonist-specific) desensitization of beta-adrenergic receptors (beta ARs) is accompanied by and appears to require phosphorylation of the receptors. We have recently described a novel protein kinase, beta AR kinase, which phosphorylates beta ARs in vitro in an agonist-dependent manner.
Lohse, MJ, Lefkowitz, RJ, Caron, MG, Benovic, JL   +3 more
openaire   +3 more sources

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor. [PDF]

Journal of Biological Chemistry, 1994
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the activated form of the beta 2-adrenergic receptor (beta 2AR) and related G protein-coupled receptors. To further elucidate the role of beta ARK in receptor desensitization, we generated a beta ARK dominant negative mutant by converting an invariant lysine residue in the ...
Guanghui Kong, Raymond B. Penn, J.L. Benovic   +2 more
openalex   +3 more sources

Essential role of β-adrenergic receptor kinase 1 in cardiac development and function [PDF]

Proceedings of the National Academy of Sciences, 1996
The β-adrenergic receptor kinase 1 (βARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. We have cloned and disrupted the βARK1 gene in mice by homologous recombination. No homozygote βARK1 −/−
Howard A. Rockman, Robert J. Lefkowitz, Mohamed Jaber, John Ross, Walter J. Koch, Bradley R. Smith, Marc G. Caron, Bruno Giros, Bruno Giros, Richard A. Bond, Kathleen K. Sulik   +10 more
openaire   +3 more sources

Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase [PDF]

Journal of Biological Chemistry, 1997
Pressure overload cardiac hypertrophy in the mouse was achieved following 7 days of transverse aortic constriction. This was associated with marked beta-adrenergic receptor (beta-AR) desensitization in vivo, as determined by a blunted inotropic response to dobutamine. Extracts from hypertrophied hearts had approximately 3-fold increase in cytosolic and
John J. Hunter, Walter J. Koch, Howard A. Rockman, Dong-Ju Choi   +3 more
openaire   +3 more sources

Angiotensin receptor blockade improves myocardial beta-adrenergic receptor signaling in postinfarction left ventricular remodeling

Journal of the American College of Cardiology, 2004
We tested the hypothesis that angiotensin II type 1 receptor blocker (ARB) may improve beta-adrenergic receptor (AR) coupling in heart failure (HF) after myocardial infarction (MI).Beta-AR desensitization is one of the mechanisms underlying the transition from compensated to decompensated HF.
Toshihisa Anzai, Toshiyuki Takahashi, Michikado Iwata, Tsutomu Yoshikawa, Satoshi Ogawa, H. Kirk Hammond, Yuichiro Maekawa, Keitaro Mahara   +7 more
openaire   +3 more sources

Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor.

, 1985
P Nambi, J R Peters, David R. Sibley, R J Lefkowitz   +3 more
openalex   +1 more source

Desensitization of the human beta 1-adrenergic receptor. Involvement of the cyclic AMP-dependent but not a receptor-specific protein kinase.

, 1991
Xuan Zhou, Peter H. Fishman
openalex   +1 more source

Chronic .BETA.-Adrenergic Receptor Stimulation Enhances the Expression of G-Protein Coupled Receptor Kinases, GRK2 and GRK5, in Both the Heart and Peripheral Lymphocytes

, 2005
Naotsugu Oyama, Kazushi Urasawa, Satoshi Kaneta, Hidetsugu Sakai, Takahiko Saito, Chika Takagi, Ichiro Yoshida, Akira Kitabatake, Hiroyuki Tsutsui   +8 more
openalex   +2 more sources

Unmasking effect of alamethicin on the (Na+,K+)-ATPase, beta-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles.

, 1980
Larry R. Jones, Stephen W. Maddock, Henry R. Besch   +2 more
openalex   +1 more source

Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization. [PDF]

, 1994
Meng-Fu Maxwell Shih, C C Malbon
openalex   +1 more source