Results 91 to 100 of about 141,853 (282)

Recent Progress in the Use of Glucagon and Glucagon Receptor Antagonists in the Treatment of Diabetes Mellitus [PDF]

, 2014
Glucagon is an important pancreatic hormone, released into blood circulation by alpha cells of the islet of Langerhans. Glucagon induces gluconeogenesis and glycogenolysis in hepatocytes, leading to an increase in hepatic glucose production and ...
Ahn JM, Al-Shamsi M, Ali S, Baggio LL, Birnbaumer L, Brand CL, Brand CL, Brand CL, Brand CL, Burcelin R, Cascieri MA, Cho YM, Christensen DP, Conarello SL, Costa FF, Dallas-Yang Q, Dharanipragada R, Duffy JL, Ernest Adeghate, Evans-Molina C, Gelling RW, Gyorgy Szalai, Hamm CA, Hansen LH, Hruby VJ, Hruby VJ, Huba Kalasz, Jaipaul Singh, Jiang G, Johnson DG, Kawai K, Kim RM, Knappe TA, Kodra JT, Kurukulasuriya R, Ladouceur GH, Lau J, Lee Y, Liang R, Liang Y, Ling A, Ling A, Lister R, Lok S, Longuet C, McGarry JD, Merlen C, Mohamed Lotfy, Parker JC, Parker JC, Petersen KF, Pierce KL, Pinney SE, Pogribny IP, Ponery AS, Potterat O, Quesada I, Qureshi SA, Ray-Gallet D, Rivera N, Shah P, Shah P, Shen DM, Shen DM, Shiao LL, Sinz C, Sloop KW, Sorensen H, Soupart A, Unson CG, Van Tine BA, Wang Q, Xu E, Zhang BB   +73 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

β-alanine spectrophotometric determination in reaction with sodium salt of 1,2-naphthoquinone-4-sulfonic acid

Zaporožskij Medicinskij Žurnal, 2015
Aim. The new spectrophotometric method for the quantitative determination of β-alanine in pharmaceutical formulations has been developed. Methods and results. This method is based on the measurement of aqueous β-alanine solutions absorption at 470 nm.
K. P. Portna, S. O. Vasyuk
doaj   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of Plasmodium falciparum and Eimeria tenella [PDF]

, 2005
The metabolic SearcH And Reconstruction Kit (metaSHARK) is a new fully automated software package for the detection of enzyme-encoding genes within unannotated genome data and their visualization in the context of the surrounding metabolic network ...
McConkey, G.A., Pinney, J.W., Shirley, M.W., Westhead, D.R.   +3 more
core   +2 more sources

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

The effect of two β-alanine dosing strategies on 30-minute rowing performance: a randomized, controlled trial

Journal of the International Society of Sports Nutrition, 2018
Background β-alanine (βA) supplementation has been shown to increase intramuscular carnosine content and subsequent high-intensity performance in events lasting  0.05) with comparable values at T3 for mean distance (βA1: 163.9 ± 3.8 m; βA2: 161.2 ± 3.5 m;
Liam Beasley, Lee Smith, Jose Antonio, Dan Gordon, James Johnstone, Justin Roberts   +5 more
doaj   +1 more source

Ayudas ergogénicas en la prevención de pérdida de masa muscular en el deporte [PDF]

, 2016
La ingesta de ayudas ergogénicas nutricionales cada vez está adquiriendo más importancia en población deportista. Para obtener los efectos esperados es necesario individualizar los protocolos de suplementación de acuerdo con las características de cada ...
Muñoz Baeza, Sonsoles
core  

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila

eLife, 2017
The recycling of neurotransmitters is essential for sustained synaptic transmission. In Drosophila, histamine recycling is required for visual synaptic transmission.
Yongchao Han, Liangyao Xiong, Ying Xu, Tian Tian, Tao Wang   +4 more
doaj   +1 more source