Results 71 to 80 of about 141,853 (282)

The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]

, 2014
Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core   +2 more sources

Effect of β-alanine supplementation on 20 km cycling time trial performance [PDF]

, 2014
The effects of β-alanine supplementation on high-intensity cycling performance and capacity have been evaluated, although the effects on longer duration cycling performance are unclear.
Artioli GG, Baguet A, Baron B, Batterham AM, Bellinger PM, Boldyrev AA, Borg GAV, Chung W, Decombaz J, Derave W, Derave W, Dutka TL, Everaert I, Harris RC, Harris RC, Hill CA, Hinckson EA, Hipkiss AR, Hobson RM, Hopkins WG, Hopkins WG, Sale C, Sale C, Sale C, Sale C, Smith AE, Smith AE, St Clair Gibson A, Stellingwerff T, Stout JR, Stout JR, Van Thienen R   +31 more
core   +5 more sources

Non‐Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease

Advanced Materials, EarlyView.
The glucose‐functionalized nanoparticles (GNPs) are developed for the brain‐targeted delivery of cannabidiol (CBD). GNPs bypass the blood‐brain barrier (BBB) via glucose transporter‐1 (GLUT‐1) and release CBD in response to reactive oxygen species (ROS).
Yibin Wang, Yundong Li, Xin Wang, Yaning Hou, Wei Deng, Meng Zheng, Yan Zou, Bingyang Shi   +7 more
wiley   +1 more source

New Strategies in Sport Nutrition to Increase Exercise Performance. [PDF]

, 2016
Despite over 50 years of research, the field of sports nutrition continues to grow at a rapid rate. Whilst the traditional research focus was one that centred on strategies to maximize competition performance, emerging data in the last decade has ...
A. Philp, Agostoni, Alam, Athenstaedt, Atherton, Baar, Baar, Bang, Bar-Peled, Bartlett, Bartlett, Bergstrom, Beugnet, Bieganowski, Blancquaert, Bodine, Booth, Breen, Buford, Buijsse, Burke, Burke, Burke, Burke, Burke, Burke, Burke, Burke, Canto, Canto, Carr, Carr, Carter, Carter, Cermak, Chambers, Chen, Chesley, Christie, Church, Churchward-Venne, Close, Close, Cobley, Cobley, Cobley, Cochran, Cochran, Cox, Coyle, Crozier, D.L. Hamilton, Dalbo, de Ligt, de Oliveira, Demay, Devries, Dickinson, Dodd, Drummond, Egan, Elliot, Faigenbaum, Fang, Fentz, Forman, G.L. Close, Gibala, Gilde, Gliemann, Gomez-Cabrera, Gomez-Cabrera, Gonzalez, Gowans, Greenhaff, Gualano, Gutierrez-Salmean, Halliwell, Hamilton, Hansen, Hardie, Harris, Havemann, Hawley, Hawley, Hoffman, Howarth, Howatson, Howlett, Howlett, Hulston, Hultstrom, Ikeda, Impey, J.P. Morton, Jager, Jeukendrup, Jeukendrup, Jones, Jonvik, Joy, Kasper, Knapik, Knapik, Kunkel, L.M. Burke, Lane, Lane, Lane, Lee, MacKay, Mackenzie, McBride, McCarthy, McGee, McGee, McGee, McGee, Meyer, Mieulet, Mobley, Moore, Moore, Moritani, Morrison, Morton, Muoio, Murase, Murphy, Nieman, Nissen, Nogueira, Nongonierma, Nongonierma, Ogasawara, Ohanna, Olesen, Outram, Owens, Owens, Owens, Paulsen, Pehmoller, Perry, Pervaiz, Petersen, Pfeiffer, Pfeiffer, Pfeiffer, Phillips, Philp, Phinney, Pilegaard, Psilander, Reid, Ristow, Rivera-Brown, Safdar, Sakamoto, Sakamoto, Scribbans, Seynnes, Sies, Spriet, Stegen, Stellingwerff, Stellingwerff, Stellingwerff, Stellingwerff, Tamura, Tanner, Thompson, Timmers, Tipton, Trigun, Van Proeyen, Vieth, Volek, Weigl, Widrick, Wilkinson, Winder, Witard, Wojtaszewski, Womack, Yeo, Yeo, Yeo, You, Zhang, Zheng, Zittermann   +191 more
core   +1 more source

Bioinspired, Mitochondria‐Targeted Single‐Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​

Advanced Materials, EarlyView.
A bioinspired nanozyme—triphenylphosphonium (TPP)‐dendritic mesoporous silica nanoparticle (DMSN)‐Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical‐sized bone defects rat ...
Yuwen Wang, Xinzhi Liang, Tiandi Xiong, Zheng Zhong, Ning Zhang, Boguang Yang, Dong Li, Qiongjiao Zeng, Xian Chen, Yiting Lei, Shangsi Chen, Chao Zheng, Liu Yang, Wei Huang, Rocky S. Tuan, Denghui Xie, Zhong Alan Li   +16 more
wiley   +1 more source

Efeito da suplementação de beta-alanina no desempenho: uma revisão crítica

Revista Brasileira de Nutrição Esportiva, 2018
A beta-alanina é um aminoácido não proteogênico precursor limitante da síntese da carnosina. O aumento da carnosina muscular tem sido considerado um fator de reforço das capacidades físicas e diminuição da fadiga neuromuscular.
Bruna Amorim Zandoná, Cleyton dos Santos de Oliveira, Ragami C. Alves, André de Camargo Smolarek, Tácito Pessoa de Souza Junior   +4 more
doaj  

Beta-alanine supplementation, muscle carnosine and exercise performance

Current Opinion in Clinical Nutrition and Metabolic Care, 2015
The use of dietary supplements in sports is widespread as athletes are continuously searching for strategies to increase performance at the highest level. Beta-alanine is such a supplement that became increasingly popular during the past years. This review examines the available evidence regarding the optimization of supplementation, the link between ...
Blancquaert, Laura, Everaert, Inge, Derave, Wim   +2 more
openaire   +3 more sources

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates [PDF]

, 2006
Hairpin polyamide–chlorambucil conjugates containing an {alpha}-diaminobutyric acid ({alpha}-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized {gamma}-DABA turn.
Chou, C. James, Dervan, Peter B., Farkas, Michelle E., Gottesfeld, Joel M., Tsai, Sherry M.   +4 more
core   +4 more sources

A Reusable Polymeric Sensor Based on Green‐Synthesized CQDs@ZIF‐8 for the Rapid Detection of Nitro‐Explosive Picric Acid

Advanced Materials Interfaces, EarlyView.
This study presents the rational design and synthesis of a highly luminescent polymeric nanocomposite. Initially, highly fluorescent carbon quantum dots (CQDs) are synthesized via a facile hydrothermal method using citric acid and β‐alanine as precursors, followed by rigorous purification through centrifugation and filtration.
Yunus Emre Toprak, Soner Çubuk, Memet Vezir Kahraman   +2 more
wiley   +1 more source