Results 121 to 130 of about 132,874 (266)

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

open access: yesAdvanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li   +12 more
wiley   +1 more source

Editorial: Nutritional Buffering Strategies to Improve Exercise Capacity and Performance

open access: yesFrontiers in Nutrition, 2021
Bryan Saunders   +3 more
doaj   +1 more source

Supplementation for athletes – part 3 – beta-alanine

open access: yesFarmacja Polska
Przedmiot badań: Wpływ suplementacji beta-alaniny na wyniki sportowców osiągane przez sportowców. Tematykę podjęto ze względu na stosowanie różnych, nie zawsze o udokumentowanej skuteczności, suplementów diety u szerokiej rzeszy sportowców o różnym stopniu wytrenowania.
Bartłomiej Dorożyński   +3 more
openaire   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

open access: yesAdvanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng   +6 more
wiley   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

open access: yesAdvanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo   +19 more
wiley   +1 more source

Metabolismo de carnosina, suplementação de β-alanina e desempenho físico: uma atualização – PARTE II

open access: yesRevista Brasileira de Nutrição Esportiva, 2015
Diversos são os fatores que podem levar à fadiga muscular durante os exercícios de alta intensidade e curta duração. Dentre eles, o acúmulo de íons H+, levando a uma queda do pH intramuscular, é apontado como uma das principais causas da fadiga durante ...
Paola Freitas   +4 more
doaj  

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

open access: yesAdvanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu   +13 more
wiley   +1 more source

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