Results 61 to 70 of about 136,703 (306)

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

β-alanine supplementation improves in-vivo fresh and fatigued skeletal muscle relaxation speed [PDF]

, 2017
Purpose: In fresh muscle, supplementation with the rate-limiting precursor of carnosine, β-alanine (BA), results in a decline in muscle half-relaxation time (HRT) potentially via alterations to calcium (Ca2+) handling. Accumulation of hydrogen cation (H+)
B Ahlborg, Billy Maritza, C Lamont, C Sale, C Sale, C Sale, CA Hill, Cleveland Thomas Barnett, Craig Sale, D Lakens, DA Jones, DG Allen, DG Allen, DR Laver, DR Laver, EJ Baran, GP Zaloga, H Westerblad, H Westerblad, I Everaert, J Decombaz, JM Gillis, Joel Davidson, K Tran, KA Edman, KJ Preacher, L Dux, L Nogueira, M Bergström, M Muntener, MA Batrukova, MJ Comeau, MW Berchtold, NA Tillin, P Swietach, R Hannah, R Hannah, RC Harris, Rebecca Louise Jones, RM Hobson, Roger Harris, SC Little, TL Dutka, TL Dutka, V Guglielmi, William D. Fraser   +45 more
core   +3 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Fragmented dosing of β-alanine induces a body weight-independent pharmacokinetic response [PDF]

, 2019
Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects.
Derave, Wim, Pringels, Lauren, Stautemas, Jan, Van de Loock, Alexia, Van der Stede, Thibaux   +4 more
core   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Recent Progress in the Use of Glucagon and Glucagon Receptor Antagonists in the Treatment of Diabetes Mellitus [PDF]

, 2014
Glucagon is an important pancreatic hormone, released into blood circulation by alpha cells of the islet of Langerhans. Glucagon induces gluconeogenesis and glycogenolysis in hepatocytes, leading to an increase in hepatic glucose production and ...
Ahn JM, Al-Shamsi M, Ali S, Baggio LL, Birnbaumer L, Brand CL, Brand CL, Brand CL, Brand CL, Burcelin R, Cascieri MA, Cho YM, Christensen DP, Conarello SL, Costa FF, Dallas-Yang Q, Dharanipragada R, Duffy JL, Ernest Adeghate, Evans-Molina C, Gelling RW, Gyorgy Szalai, Hamm CA, Hansen LH, Hruby VJ, Hruby VJ, Huba Kalasz, Jaipaul Singh, Jiang G, Johnson DG, Kawai K, Kim RM, Knappe TA, Kodra JT, Kurukulasuriya R, Ladouceur GH, Lau J, Lee Y, Liang R, Liang Y, Ling A, Ling A, Lister R, Lok S, Longuet C, McGarry JD, Merlen C, Mohamed Lotfy, Parker JC, Parker JC, Petersen KF, Pierce KL, Pinney SE, Pogribny IP, Ponery AS, Potterat O, Quesada I, Qureshi SA, Ray-Gallet D, Rivera N, Shah P, Shah P, Shen DM, Shen DM, Shiao LL, Sinz C, Sloop KW, Sorensen H, Soupart A, Unson CG, Van Tine BA, Wang Q, Xu E, Zhang BB   +73 more
core   +1 more source

A cross-comparative pharmacokinetic study of Klimalanin (ingestion or sublingual intake)

Гинекология, 2013
Beta-alanine (Klimalanin) is generally used for the treatment and prevention of vasomotor disturbances (hot flushes) in menopausal period. This paper presents the results of a comparative analysis of the beta-alanine pharmacokinetics with a single ...
I S Yurghel, O A Limanova, T B Siling, I Yu Torshin, A N Gromov, A Yu Volkov, E Yu Egorova, O A Gromova   +7 more
doaj  

The Effects of a Multi-Ingredient Performance Supplement Combined with Resistance Training on Exercise Volume, Muscular Strength, and Body Composition

Sports, 2019
The effects of a multi-ingredient performance supplement (MIPS) incorporating a mixture of branched chain amino acids, beta-alanine, glutamine, creatine, and piperine on resistance training (RT)-induced adaptations remains unclear. Therefore, the purpose
Dean Directo, Michael W.H. Wong, Marcus L. Elam, Paul Falcone, Adam Osmond, Edward Jo   +5 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source