Results 81 to 90 of about 83,989 (289)

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Modelling Coronavirus and Larvae Pyrausta Data: A Discrete Binomial Exponential II Distribution with Properties, Classical and Bayesian Estimation

Axioms, 2022
In this article, we propose the discrete version of the binomial exponential II distribution for modelling count data. Some of its statistical properties including hazard rate function, mode, moments, skewness, kurtosis, and index of dispersion are ...
Mohamed S. Eliwa, Abhishek Tyagi, Bader Almohaimeed, Mahmoud El-Morshedy   +3 more
doaj   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

Analysis of Weibull progressively first-failure censored data with beta-binomial removals

AIMS Mathematics
This study examined the estimations of Weibull distribution using progressively first-failure censored data, under the assumption that removals follow the beta-binomial distribution.
Refah Alotaibi , Mazen Nassar , Zareen A. Khan , Ahmed Elshahhat   +3 more
doaj   +1 more source

Scalable shared protection approach for mesh WDM-routed networks [PDF]

, 2004
The paper proposes an approach for calculating the protection pool size on each link in a mesh WDMrouted network. The protection pool evaluation is part of a shared protection scheme applied to a failure dependent scenario and based on aggregated ...
Harle, D.A., Touvet, Florence
core  

An Extension of Generalized Linear Models to Finite Mixture Outcome Distributions

, 2016
Finite mixture distributions arise in sampling a heterogeneous population. Data drawn from such a population will exhibit extra variability relative to any single subpopulation.
Morel, Jorge G., Neerchal, Nagaraj K., Raim, Andrew M.   +2 more
core   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Circular Polya distributions of order k

International Journal of Mathematics and Mathematical Sciences, 2003
Two circular Polya distributions of order k are derived by means of generalized urn models and by compounding, respectively, the type I and type II circular binomial distributions of order k of Makri and Philippou (1994) with the beta distribution. It is
Gregory A. Tripsiannis, Andreas N. Philippou   +1 more
doaj   +1 more source

scDemultiplex: An iterative beta-binomial model-based method for accurate demultiplexing with hashtag oligos

Computational and Structural Biotechnology Journal, 2023
Single-cell sequencing have been widely used to characterize cellular heterogeneity. Sample multiplexing where multiple samples are pooled together for single-cell experiments, attracts wide attention due to its benefits of increasing capacity, reducing ...
Li-Ching Huang, Lindsey K. Stolze, Hua-Chang Chen, Alexander Gelbard, Yu Shyr, Qi Liu, Quanhu Sheng   +6 more
doaj   +1 more source