Results 151 to 160 of about 1,125,892 (364)
Advanced Science, EarlyView.CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen +10 more
wiley +1 more source
Cancer Management and Research, 2019 Kankan Yang,1,* Bing Jiang,1,* Yecai Lu,1,* Qingbing Shu,1 Pan Zhai,1 Qiaoming Zhi,2 Qixin Li1 1Department of Gastrointestinal Surgery, Chaohu Hospital of Anhui Medical University, Hefei 238000, Anhui, China; 2Department of General Surgery, The First ...
Yang K +6 more
doaj
Advanced Science, EarlyView.CCDC183‐AS1 overexpression enhanced the ability of PCa cells to spread to the bone by inducing osteoclastogenesis. Mechanistically, CCDC183‐AS1 interacted with FUBP1 and enhanced its stability, which promoted the transcription of TNFSF14 (LIGHT). Copy number gain‐induced KDM5C epigenetically upregulated CCDC183‐AS1 expression by recruiting TET1 to the ...
Chuandong Lang +10 more
wiley +1 more source
Wnt/beta-catenin signaling: components, mechanisms, and diseases.
Developmental Cell, 2009 Bryan T. MacDonald, K. Tamai, Xi He
semanticscholar +1 more source
Clinical significance of disordered beta-catenin expression pattern in human gastric cancers [PDF]
, 2000 Takehiro Utsunomiya +8 more
openalex +1 more source
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications
Advanced Science, EarlyView.This study uses multiomics approaches to characterize bovine myogenesis in vitro, identifying media components that enhance myogenic progenitor cell differentiation in 2D and 3D models. Notably, the enhanced conditions promoted formation of unique cell populations and contractile muscle cells expressing mature myogenic markers.
Christine L. Trautmann +4 more
wiley +1 more source
Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors.
Cancer Treatment Reviews, 2018 Nithya Krishnamurthy, R. Kurzrock
semanticscholar +1 more source
Pontin52 and Reptin52 function as antagonistic regulators of beta-catenin signalling activity [PDF]
, 2000 Andreas Bauer +7 more
openalex +1 more source