Results 1 to 10 of about 196,006 (119)

Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity [PDF]

Cell Death and Disease
The aberrant Wnt/β-catenin signaling is tightly associated with developmental disorders and tumorigenesis. However, spatial regulation of cytoplasmic β-catenin with regard to its nuclear accumulation and signaling activation remains poorly understood ...
Muhah Jeong, Shin-Hyeon Ryu, Young-Sin Cho, Do-Hyeong Na, Jongyeon Baek, Jihoon Nah, Ki Woo Kim, Yong-Keun Jung   +7 more
doaj   +2 more sources

Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts

Frontiers in Cell and Developmental Biology, 2022
The etiology of age-related cortical cataracts is not well understood but is speculated to be related to alterations in cell adhesion and/or the changing mechanical stresses occurring in the lens with time.
Jessica B. Martin, Kenneth Herman, Nathalie S. Houssin, Wade Rich, Matthew A. Reilly, Matthew A. Reilly, Timothy F. Plageman   +6 more
doaj   +1 more source

p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development in vitro

Frontiers in Cellular Neuroscience, 2023
Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer’s disease and schizophrenia.
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Christina M. Di Mauro, Adriana Paulucci-Holthauzen, M. Neal Waxham, M. Neal Waxham, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +9 more
doaj   +1 more source

Delta-Catenin as a Modulator of Rho GTPases in Neurons

Frontiers in Cellular Neuroscience, 2022
Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +5 more
doaj   +1 more source

Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation. [PDF]

PLoS ONE, 2013
β-catenin, an adherens junction component and key Wnt pathway effector, regulates numerous developmental processes and supports embryonic stem cell (ESC) pluripotency in specific contexts.
Sujeivan Mahendram, Kevin F Kelly, Sabrina Paez-Parent, Sharmeen Mahmood, Enio Polena, Austin J Cooney, Bradley W Doble   +6 more
doaj   +1 more source

ECCU (E-cadherin/catenin) complex and its role in carcinogenesis

Journal of Education, Health and Sport, 2020
Introduction:One of the main characteristics of cancer is uncontrolled cell proliferation as well as loss of cells adhesion in the case of metastases. Cadherins and catenins are the molecules responsible for cell-to-cell interaction.
Alicja Maria Ozga, Aleksandra Obuchowska, Justyna Wójcik, Arkadiusz Standyło, Paulina Piotrowska   +4 more
doaj   +1 more source

Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells

BMC Cancer, 2005
Background Deregulation of the Wnt/ β-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues.
Enver Tariq, Kenny Paraic A, Ashworth Alan   +2 more
doaj   +1 more source

Large Ovarian Microcystic Stromal Tumour: A Report of Rare and Distinctive Pathological Entity [PDF]

Journal of Clinical and Diagnostic Research
Microcystic Stromal Tumours (MCSTs) of the ovary are an exceedingly rare and distinct subtype of ovarian stromal neoplasms, characterised by their unique histopathological features. They were first identified in 2019 as a distinct entity.
Rhea Sharon Susihar, Kalaivani Amitkumar, Meethu Rappai   +2 more
doaj   +1 more source

Discovery of novel small molecule activators of β-catenin signaling. [PDF]

PLoS ONE, 2011
Wnt/β-catenin signaling plays a major role in embryonic development and adult stem cell maintenance. Reduced activation of the Wnt/β-catenin pathway underlies neurodegenerative disorders and aberrations in bone formation.
Folkert Verkaar, Mario van der Stelt, W Matthijs Blankesteijn, Antoon A van der Doelen, Guido J R Zaman   +4 more
doaj   +1 more source

Z-Ajoene Inhibits Growth of Colon Cancer by Promotion of CK1α Dependent β-Catenin Phosphorylation

Molecules, 2020
Aberrant activation of a Wnt/β-catenin pathway results in nuclear accumulation of β-catenin in colon cancer. Inhibiting β-catenin is one strategy for treating colon cancer.
Hua Li, Ji Hye Jeong, Sung Won Kwon, Sang Kook Lee, Hwa Jin Lee, Jae-Ha Ryu   +5 more
doaj   +1 more source