Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis [PDF]
eLife, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Blair W Benham-Pyle +4 more
doaj +4 more sources
Genome Biology, 2019 Background Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin.
Wei-Cheng Liang +10 more
doaj +2 more sources
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
Cell Death and Differentiation, 2022 The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang +14 more
semanticscholar +1 more source
Wnt/β-catenin signaling in cancers and targeted therapies
Signal Transduction and Targeted Therapy, 2021 Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression ...
F. Yu +8 more
semanticscholar +1 more source
β-Catenin signaling in hepatocellular carcinoma
Journal of Clinical Investigation, 2022 Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular carcinoma (HCC). Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which encodes β-catenin, and loss-of-function ...
Chuanrui Xu +5 more
semanticscholar +1 more source
Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R [PDF]
, 2013 Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the
Bertherat, Jérôme +11 more
core +8 more sources
E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]
, 2015 Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke +27 more
core +2 more sources
Targeting the Wnt/β-catenin signaling pathway in cancer
Journal of Hematology & Oncology, 2020 The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response.
Ya Zhang, Xin Wang
semanticscholar +1 more source
Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]
, 2019 Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John +2 more
core +1 more source
Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes. [PDF]
, 2016 Mu-protocadherin (MUCDHL) is an adhesion molecule predominantly expressed by colorectal epithelial cells which is markedly downregulated upon malignant transformation.
Calabretta, Bruno +11 more
core +2 more sources