Results 11 to 20 of about 234,883 (311)

Exchange of catenins in cadherin–catenin complex [PDF]

Oncogene, 2003
beta-Catenin is an intracellular multifunctional protein. In complex with the transmembrane adhesive receptor E-cadherin, it becomes plasma membrane-associated and mediates intercellular adhesion. A cytosolic pool of beta-catenin interacts with DNA-binding proteins and participates in signal transduction. To reveal the possible cross-talk between these
Klingelhöfer, Jörg, Troyanovsky, Regina B, Laur, Oscar Y, Troyanovsky, Sergey   +3 more
openaire   +3 more sources

Expression of β-Catenin and γ-Catenin in Maxillary Bone Regeneration [PDF]

International Journal of Immunopathology and Pharmacology, 2011
β- and γ-catenin are components of catenin family involved in cadherin adhesion function. Recently it has been shown that this family is involved in other functions such as signaling and activation of transcription factors. The final goal of this study was to evaluate the role of β- and γ-catenin in bone cell physiology and bone regeneration.
A. SANTARELLI, G. COLELLA, F. CARINCI, G. PANNONE, R. RUBINI, L. LO RUSSO, POLIMENI, Antonella, N. SGARAMELLA, ANNIBALI, Susanna, G. SPINELLI, L. LO MUZIO   +10 more
openaire   +4 more sources

Identification of the Domain of α-Catenin Involved in Its Association with β-Catenin and Plakoglobin (γ-Catenin) [PDF]

Journal of Biological Chemistry, 1997
alpha-Catenin is a 102-kDa protein exhibiting homology to vincuin, and it forms complexes with cadherins or the tumor-suppressor gene product adenomatous polyposis coli through binding to beta-catenin or plakoglobin (gamma-catenin). The incorporation of alpha-catenin into the cadherin-catenin complexes is a prerequisite for expression of the cell ...
H, Obama, M, Ozawa
openaire   +2 more sources

The catenin family at a glance [PDF]

Journal of Cell Science, 2010
Members of the catenin family were first isolated complexed with the cytoplasmic domains of cadherins at cell-cell junctions, and this relationship is considered one of the defining aspects of catenins. Their functions at such contacts are multifaceted and remain under active study and discussion.
Pierre D, McCrea, Dongmin, Gu
openaire   +2 more sources

Structure of the Dimerization and β-Catenin- Binding Region of α-Catenin [PDF]

Molecular Cell, 2000
In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix ...
Pokutta, Sabine, Weis, William I.
openaire   +2 more sources

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
core   +1 more source

Beyond β-catenin: prospects for a larger catenin network in the nucleus [PDF]

Nature Reviews Molecular Cell Biology, 2015
β-catenin is widely regarded as the primary transducer of canonical WNT signals to the nucleus. In most vertebrates, there are eight additional catenins that are structurally related to β-catenin, and three α-catenin genes encoding actin-binding proteins that are structurally related to vinculin.
Pierre D, McCrea, Cara J, Gottardi
openaire   +2 more sources

p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction [PDF]

Molecular and Cellular Biology, 2003
beta-Catenin has a key role in the formation of adherens junction through its interactions with E-cadherin and alpha-catenin. We show here that interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases.
Jose, Piedra, Susana, Miravet, Julio, Castaño, Héctor G, Pálmer, Nora, Heisterkamp, Antonio, García de Herreros, Mireia, Duñach   +6 more
openaire   +2 more sources

S-Nitrosation of β-Catenin and p120 Catenin [PDF]

Circulation Research, 2012
Rationale: Endothelial adherens junction proteins constitute an important element in the control of microvascular permeability. Platelet-activating factor (PAF) increases permeability to macromolecules via translocation of endothelial nitric oxide synthase (eNOS) to cytosol and stimulation of eNOS ...
Marin, Natalie, Zamorano, Patricia, Carrasco, Rodrigo, Mujica, Patricio, Gonzalez, Francisco G., Quezada, Claudia, Meininger, Cynthia J., Boric, Mauricio P., Duran, Walter N., Sanchez, Fabiola A.   +9 more
openaire   +3 more sources

Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo [PDF]

, 2010
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele
Newton, Ian P., Jarnicki, Andrew G., Nathke, Inke S.; id_orcid, Sansom, Owen, Nathke, I., Samuel, M., Suzuki, Hiromu, Tosh, David, Abud, H E, Newton, IP, Huelsken, J, Stacker, SA, Samuel, M S, Buchert, M, Ernst, M., Stacker, Steven, Stacker, S., Dimitris Athineos, Alan R Clarke, Newton Ian P., Helen E. Abud, Heath, JK, Abud Helen E., Clarke Alan R., Suzuki, H., Faux, Maree, Newton, I., Jarnicki, A.G., Meniel, VS, Michael Buchert, Ernst, Matthias, Sansom, Owen J., Sansom Owen J., Meniel, Valerie, Clarke, Alan R., Burke, Z D, Ian P Newton, Inke S Näthke, David Tosh, Näthke, I.S., Winbanks, Catherine, Ian P. Newton, Sansom, O J, Burke, Z., Samuel Michael S., Samuel, M.S., Näthke Inke S., Inke S. Näthke, Jarnicki, A G, Abud, H.E., Tosh, D, Burke, ZD, Catherine E Winbanks, Samuel, Michael S., Heath Joan K., Andrew G Jarnicki, Nusse, R., Jarnicki, Andrew, Meniel, V.S., Abud, H., Samuel, MS, Joan K Heath, Winbanks, C E, Clarke, A R, Winbanks, C.E., Suzuki Hiromu, Winbanks Catherine E., Clarke, Alan Richard, Clarke, A.R., Joerg Huelsken, Stacker, Steven A., Helen E Abud, Alan R. Clarke, Buchert, M., Owen J. Sansom, Abud, HE, Joan K. Heath, Faux Maree C., Jarnicki, AG, Owen J Sansom, Athineos Dimitris, Suzuki, H, Faux, M., Winbanks, C., Matthias Ernst, Huelsken Joerg, Athineos, D, Sansom, O.J., Burke, Zoe D., Meniel Valerie S., Huelsken, J., Tosh David, Newton, I.P., Samuel, Michael, Athineos, Dimitris, Ernst Matthias, Jarnicki Andrew G., Zoe D Burke, Stacker, S.A., Stacker, S A, Clarke, Alan, Buchert, Michael, Abud, Helen E., Michael S. Samuel, Jarnicki, A., Steven A Stacker, Meniel, Valerie S., Faux, M C, Athineos, D., Meniel, V., Ernst, M, Michael S Samuel, Heath, Joan K., Nathke, I S, Sansom, OJ, Newton, Ian, Tosh, D., Valerie S. Meniel, Clarke, AR, Newton, I P, Näthke, Inke S., Meniel, V S, Valerie S Meniel, Buchert Michael, Newton, Ian P, Heath, Joan, Maree C Faux, Näthke, IS, Burke, Z.D., Heath, J., Maree C. Faux, Faux, Maree C., Winbanks, Catherine E., Heath, J K, Faux, M.C., Abud, Helen, Catherine E. Winbanks, Faux, MC, Sansom, O., Burke, Zoe, Andrew G. Jarnicki, Steven A. Stacker, Hiromu Suzuki, Zoe D. Burke, Huelsken, Joerg, Heath, J.K., Stacker Steven A., Burke Zoe D., Winbanks, CE, Nathke, Inke, Clarke, A.   +150 more
core   +1 more source