Results 31 to 40 of about 234,883 (311)

Exiting the dark side: A vital role for Caspase-3 in Yap signaling

Molecular & Cellular Oncology, 2018
Caspase-3 is known to play a critical function in the process of apoptosis. Recently, we have discovered a non-apoptotic role of Caspase-3 as a key regulator of cell proliferation and organ size.
Yahav Yosefzon, Yaron Fuchs
doaj   +1 more source

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells

Haematologica, 2019
Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients ...
Rhys G. Morgan, Jenna Ridsdale, Megan Payne, Kate J. Heesom, Marieangela C. Wilson, Andrew Davidson, Alexander Greenhough, Sara Davies, Ann C. Williams, Allison Blair, Marian L. Waterman, Alex Tonks, Richard L. Darley   +12 more
doaj   +1 more source

90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus

Neoplasia: An International Journal for Oncology Research, 2016
β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation.
So-Yeon Park, Somy Yoon, Hangun Kim, Kyung Keun Kim   +3 more
doaj   +1 more source

Beta-catenin in disease

Journal of Oral and Maxillofacial Pathology, 2016
In continuation with the previous review on "β-catenin in health", in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours.
Prakash, Sharada, Swaminathan, Uma, Nagamalini, BR, Krishnamurthy, Ashwini Balkuntla   +3 more
openaire   +3 more sources

The epithelial-mesenchymal transition induced by transcription factor LEF-1 is independent of β-catenin

Biochemistry and Biophysics Reports, 2018
Transcription factor lymphoid-enhancer–binding factor 1 (LEF-1) is a key molecule in the Wnt/β-catenin signaling pathway. Slug is one of the Wnt/β-catenin target genes and can induce epithelial–mesenchymal transition (EMT). Previously, we have shown that
Wakako Kobayashi, Masayuki Ozawa
doaj   +1 more source

Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.

PLoS ONE, 2013
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithelial cell-cell adhesion. Reduction and loss of catenin expression degrades E-cadherin-mediated carcinoma cell-cell adhesion and causes carcinomas to ...
Kazunobu Sasaya, Haruka Sudo, Genta Maeda, Shuichi Kawashiri, Kazushi Imai   +4 more
doaj   +1 more source

Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells [PDF]

, 2006
Swiss Cancer League, Swiss National Science Foundation and SNSF NCCR Molecular Oncology ProgrammeBackground: The Wnt signaling pathway is activated by mutations in the APC and beta-catenin genes in many types of human cancer.
Homicsko, Krisztian, Pittet Anne-Laure, Christophe Fuerer, Lukashev, Alexander N., Homicsko Krisztian, Alexander N Lukashev, Fuerer Christophe, Anne-Laure Pittet, Iggo, Richard D., Fuerer, Christophe, Pittet, Anne-Laure, Richard D Iggo, Lukashev Alexander N, Iggo Richard D, Krisztian Homicsko   +14 more
core   +1 more source

Role of a Pdlim5:PalmD complex in directing dendrite morphology

Frontiers in Cellular Neuroscience
Neuronal connectivity is regulated during normal brain development with the arrangement of spines and synapses being dependent on the morphology of dendrites.
Yogesh Srivastava, Maxsam Donta, Maxsam Donta, Lydia L. Mireles, Adriana Paulucci-Holthauzen, M. Neal Waxham, M. Neal Waxham, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +9 more
doaj   +1 more source

Кардіоспецифічна делеція α-Е-катеніну спричиняє зменшення експресії основного компонента десмосом γ-катеніну

Фактори експериментальної еволюції організмів, 2017
Aim. In our present work, we have addressed to the γ-catenin, known main component of desmosomes, expression in hearts with heterozygous and homozygous knockout of α-E-catenin gene. Methods. Alpha-E-catenin conditional knockout mice were bred with α-MHC-
V. V. Balatskyi, L. L. Matsevych, O. O. Piven   +2 more
doaj   +1 more source

Cleavage of Desmosomal Cadherins Promotes γ-Catenin Degradation and Benefits Wnt Signaling in Coxsackievirus B3-Induced Destruction of Cardiomyocytes

Frontiers in Microbiology, 2020
Coxsackievirus B3 (CVB3) is the primary etiologic agent of viral myocarditis, a major heart disease that occurs predominantly in children and young adolescents.
Guangze Zhao, Guangze Zhao, Huifang M. Zhang, Huifang M. Zhang, Ye Qiu, Ye Qiu, Xin Ye, Xin Ye, Decheng Yang, Decheng Yang   +9 more
doaj   +1 more source