Results 31 to 40 of about 411,716 (331)

Direct targeting of β‐catenin in the Wnt signaling pathway: Current progress and perspectives

Medicinal research reviews (Print), 2021
Aberrant activation of the Wnt/β‐catenin signaling circuit is associated with cancer recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion.
Zhen Wang, Zilu Li, Haitao Ji
semanticscholar   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core   +2 more sources

WNT/β-catenin signaling in the development of liver cancers.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular mechanism that regulates embryonic development, cellular proliferation and differentiation.
Shuai He, Shilei Tang
semanticscholar   +1 more source

γ-Catenin at Adherens Junctions: Mechanism and Biologic Implications in Hepatocellular Cancer after β-Catenin Knockdown

Neoplasia: An International Journal for Oncology Research, 2013
β-Catenin is important in liver homeostasis as a part of Wnt signaling and adherens junctions (AJs), while its aberrant activation is observed in hepatocellular carcinoma (HCC).
Emily Diane Wickline, Yu Du, Donna B. Stolz, Michael Kahn, Satdarshan P.S. Monga   +4 more
doaj   +1 more source

Exiting the dark side: A vital role for Caspase-3 in Yap signaling

Molecular & Cellular Oncology, 2018
Caspase-3 is known to play a critical function in the process of apoptosis. Recently, we have discovered a non-apoptotic role of Caspase-3 as a key regulator of cell proliferation and organ size.
Yahav Yosefzon, Yaron Fuchs
doaj   +1 more source

β-Catenin is a pH sensor with decreased stability at higher intracellular pH. [PDF]

, 2018
β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which is regulated by protein-protein interactions that stabilize β-catenin or target it for ...
Aberle, Baumgartner, Bree K. Grillo-Hill, Chairoungdua, Choi, Choi, Cold Spring Harbor Protocols, Dai, Daugherty, Denker, Denker, Diane L. Barber, Endo, Forbes, Forbes, Frantz, Frescas, Grillo-Hill, Ha, Hart, Ismahan Chire, Jobelle Peralta, Katharine A. White, Klaus, Krausova, Lee, Li, Liu, Liu, Mario Esquivel, Megy, Morin, Pai, Parks, Peifer, Peifer, Petherick, Pronobis, Reim, Reshkin, Sadot, Sahai-Hernandez, Schönichen, Sedgwick, Shafique, Simons, Stamos, Stehbens, Ulmschneider, Valenta, Vivian N. Bui, Waghmare, Webb, White, White, Wolff, Wu   +56 more
core   +1 more source

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells

Haematologica, 2019
Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients ...
Rhys G. Morgan, Jenna Ridsdale, Megan Payne, Kate J. Heesom, Marieangela C. Wilson, Andrew Davidson, Alexander Greenhough, Sara Davies, Ann C. Williams, Allison Blair, Marian L. Waterman, Alex Tonks, Richard L. Darley   +12 more
doaj   +1 more source

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading [PDF]

, 2014
The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β ...
Akhter, Armstrong, Armstrong, Babij, Bodine, Bodine, Bonewald, Bouxsein, Boyden, Case, Choi, Dallas, Dempster, Diarra, Doube, Galea, Glass, Gong, Hens, Holmen, Holmen, Javaheri, Johnson, Johnson, Johnson, Kamel, Kato, Kitase, Korecki, Kramer, Lau, Li, Little, Logan, Lu, Monga, Nakashima, Nathke, Nusse, Pinson, Polakis, Reya, Robinson, Santos, Sawakami, Saxon, Schneider, Sen, Srivastava, Sunters, Wijenayaka, Xing, Xiong, Yao   +53 more
core   +2 more sources

β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma.

Cancer Discovery, 2019
PD-1 immune checkpoint inhibitors have produced encouraging results in hepatocellular carcinoma (HCC) patients. However, what determines resistance to anti-PD-1 therapies is unclear.
M. Ruiz de Galarreta, Erin R. Bresnahan, Pedro Molina-Sánchez, K. Lindblad, B. Maier, D. Sia, M. Puigvehí, Verónica Miguela, M. Casanova-Acebes, Maxime Dhainaut, C. Villacorta-Martin, A. Singhi, A. Moghe, J. von Felden, Lauren Tal Grinspan, Shuang Wang, A. Kamphorst, S. Monga, Brian D. Brown, A. Villanueva, J. Llovet, M. Merad, A. Lujambio   +22 more
semanticscholar   +1 more source

90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus

Neoplasia: An International Journal for Oncology Research, 2016
β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation.
So-Yeon Park, Somy Yoon, Hangun Kim, Kyung Keun Kim   +3 more
doaj   +1 more source