Results 291 to 300 of about 1,125,892 (364)

Bioactive siRNA‐Based Liposomes Promoted Tendon‐Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248+ TSPCs

open access: yesAdvanced Science, EarlyView.
In this study, it is found that osteoporosis leads to disturbances in the Extracellular Matrix (ECM)of tendons and thus causes a decrease in TSPC stemness, resulting in a rotator cuff that is easily damaged and prone to retearing after repair. Targeted intervention with si‐CD248‐loaded liposomes can restore TSPC stemness, promote tendon‐bone healing ...
Yinhua Qian   +14 more
wiley   +1 more source

Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells

open access: bronze, 2005
Susanne Dihlmann   +3 more
openalex   +1 more source

Tendon Aging: A Silent Enemy Revealed Strategies for Effective Treatment

open access: yesAGING MEDICINE, EarlyView.
This review commences with the mechanism of tendon aging, mainly introducing the aging of tendons induced by oxidative stress, hyperglycemia, inflammatory response, cell apoptosis, and fatty infiltration and the association with the tendon stem/progenitor cells, aiming to explore the mechanism of aging and find related treatment methods.
Wenhui Gu   +3 more
wiley   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai   +7 more
wiley   +1 more source

Novel SOX17 frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations. [PDF]

open access: yes, 2017
Cohn, David E   +8 more
core   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang   +5 more
wiley   +1 more source

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