Results 341 to 350 of about 1,125,892 (364)

Abstract A02: Beta-catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors

, 2013
The role of Wnt signaling in embryonic development and stem cell maintenance is well established and aberrations leading to the constitutive up-regulation of this pathway are frequent in several types of human cancers.
L. Grumolato, Guizhong Liu, T. Haremaki, Sathish Kumar Mungamuri, Phyllus Y. Mong, G. Akiri, P. Lopez-Bergami, A. Arita, Y. Anouar, M. Mlodzik, Z. Ronai, J. Brody, D. C. Weinstein, S. Aaronson   +13 more
semanticscholar   +1 more source

Progranulin and beta‐catenin in psoriasis: An immunohistochemical study

Journal of Cosmetic Dermatology, 2019
AbstractBackground/ObjectivesProgranulin (PGRN) is a secreted glycoprotein that was investigated in many skin diseases. It plays an important role in inflammatory response and autophagy which could be mediated through Wnt/β‐catenin pathway. However, the role of PGRN in pathogenesis of psoriasis has not been clearly well‐known.
Azza Gaber Antar Farag, Mohamed Abdalmoneim Shoaib, Rehab Mounir Samaka, Asmaa Gaber Abdou, Marwa Mahmoud Mandour, Reda Abdel Latif Ibrahim   +5 more
openaire   +3 more sources

Pharmacological inhibition of beta-catenin in hepatoblastoma cells

Pediatric Surgery International, 2012
The proto-oncogene beta-catenin is linked to an abnormal activation of the Wnt/beta-catenin-pathway and shows mutations in 50-90 % of hepatoblastoma (HB). Corresponding, the recently published murine orthotopic HB model differs from the former subcutaneous model by nuclear beta-catenin distribution.
Justus Lieber, C. Nagel, Steven W. Warmann, Joerg Fuchs, Julia Wenz, Verena Ellerkamp, Sorin Armeanu-Ebinger   +6 more
openaire   +3 more sources

Targeting the Wnt/Beta-Catenin Pathway in Multiple Myeloma with a Novel Orally Bioavailable Beta-Catenin Inhibitor

Blood, 2012
Abstract Abstract 1842 The introduction of novel chemotherapeutics and stem cell transplantation has resulted in an improved outlook for patients with multiple myeloma (MM) but the disease remains incurable emphasising the need for alternative therapeutic approaches.
Stephen K. Horrigan, Ioanna Savvidou, Tiffany Khong, Andrew Spencer   +3 more
openaire   +2 more sources

Characterization of a BETA-Catenin-Associated Kinase

1999
Abstract : Several lines of evidence suggest that accumulation of cytoplasmic Beta-catenin transduces an oncogenic signal. We show that Beta-cantenin is ubiquitinated and degraded by the proteosome and that Beta-cantenin stability is regulated by a diacylglycerol-independent protein kinase C-like kinase activity which is required for Beta-catenin ...
openaire   +1 more source

LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling

Oncogene, 2018
Jianming Tang, Yanxin Li, Y. Sang, Bo Yu, Deguan Lv, Weiwei Zhang, Haizhong Feng   +6 more
semanticscholar   +1 more source

Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription.

Cancer research, 2001
Beta-catenin undergoes both serine and tyrosine phosphorylation. Serine phosphorylation in the amino terminus targets beta-catenin for proteasome degradation, whereas tyrosine phosphorylation in the COOH terminus influences interaction with E-cadherin.
BONVINI P., AN W. G., ROSOLEN, ANGELO, NGUYEN P., TREPEL J., GARCIA DE HERREROS A., DUNACH M., NECKERS L. M.   +7 more
openaire   +2 more sources

Beta Catenin-Regulated Genes in Breast Cancer [PDF]

, 1999
Abstract : This study investigates the role of cadherin-11 in the progression of breast cancer from a less invasive, more differentiated phenotype to a more invasive, less differentiated phenotype. The cadherins are transmembrane proteins that have been shown in many previous studies to be involved in cancer progression.
openaire   +1 more source

Expression of beta-catenin in human tooth germ.

Analytical and quantitative cytology and histology, 2009
To evaluate beta-catenin expression in human tooth germ development.Specimens of 7 human fetuses aged between the ninth and sixteenth week were examined for beta-catenin expression by immunohistochemistry.In the bud stage, we observed catenin membranous positivity for all primitive dental lamina and dental ridge cells, cytoplasmic positivity for tooth ...
LO MUZIO L, LO RUSSO L, PANNONE G, SANTORO A, LEONARDI R, SERPICO, Rosario, GASPARONI A, BUFO P.   +7 more
openaire   +2 more sources

Beta-Catenin

2012
Ken-Ichi Takemaru, Xingwang Chen, Feng-Qian Li   +2 more
openaire   +1 more source